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学科主题基础医学
Deficiency of cartilage oligomeric matrix protein causes dilated cardiomyopathy
Huang, Yaqian1; Xia, Jiahong2; Zheng, Jingang3; Geng, Bin1; Liu, Peng3; Yu, Fang1; Liu, Bo1; Zhang, Hongquan4; Xu, Mingjiang1; Ye, Ping2; Zhu, Yi1; Xu, Qingbo5; Wang, Xian1; Kong, Wei1,6
关键词Dilated Cardiomyopathy Matricellular Protein Integrin Ubiquitination
刊名BASIC RESEARCH IN CARDIOLOGY
2013-09-01
DOI10.1007/s00395-013-0374-9
108期:5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]FOCAL ADHESION KINASE ; CARDIAC-HYPERTROPHY ; HEART-FAILURE ; PRESSURE-OVERLOAD ; TARGETED ABLATION ; INTEGRIN ; MICE ; GENE ; MUTATIONS ; DISEASE
英文摘要

Alterations in cardiac extracellular matrix are involved in dilated cardiomyopathy (DCM) and its progression to heart failure. The matricellular protein cartilage oligomeric matrix protein (COMP) has been indicated localized in the heart. However, the role of COMP in cardiac homeostasis and disease remains elusive. COMP-/- mice, both male and female, developed DCM spontaneously at young age (3-5 months), with impaired cardiac function. Assessment of postnatal COMP-/- heart at 1 month, although functionally normal, revealed severe cardiac ultrastructure defect, in parallel with cardiomyocyte apoptosis, myofilament loss, connexin-43 deficiency and matrix metalloproteinase activation. Decreased COMP expression was observed in the heart sample of DCM patients compared with donor heart. Mechanistically, COMP-/- heart exhibited reduced integrin beta 1 expression and signaling. Ectopic expression of COMP or integrin beta 1 rescued COMP-deficiency- induced cardiomyocyte apoptosis, myofilament dissolution, and connexin-43 aberrance. Additionally, COMP directly bonded to the extracellular beta-tail domain of integrin beta 1, prevented integrin beta 1 ubiquitination/ degradation, and maintained the cardiac homeostasis. COMP-integrin beta 1 axis is a potential target of DCM.

语种英语
WOS记录号WOS:000324212500006
项目编号81225002 ; 81220108004 ; 2012CB518002 ; 81070243 ; B07001
资助机构National Science Fund for Distinguished Young Scholars ; Projects of International Cooperation and Exchanges NSFC ; National Program on Key Basic Research Project (973 Program) ; National Natural Science Foundation of the P.R. China ; "111" Project of Chinese Ministry of Education
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53529
专题北京大学基础医学院
北京大学医学部管理机构_医学部
作者单位1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
2.Peking Univ, Basic Med Coll, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
3.Huazhong Univ Sci Technol, Union Hosp, Tongji Med Coll, Dept Cardiovasc Surg, Wuhan, Peoples R China
4.China Japan Friendship Hosp, Dept Cardiol, Beijing 100029, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Dept Anat Histol & Embryol, Beijing 100191, Peoples R China
6.Kings Coll London, James Black Ctr, Cardiovasc Div, London SE5 9NU, England
推荐引用方式
GB/T 7714
Huang, Yaqian,Xia, Jiahong,Zheng, Jingang,et al. Deficiency of cartilage oligomeric matrix protein causes dilated cardiomyopathy[J]. BASIC RESEARCH IN CARDIOLOGY,2013,108(5).
APA Huang, Yaqian.,Xia, Jiahong.,Zheng, Jingang.,Geng, Bin.,Liu, Peng.,...&Kong, Wei.(2013).Deficiency of cartilage oligomeric matrix protein causes dilated cardiomyopathy.BASIC RESEARCH IN CARDIOLOGY,108(5).
MLA Huang, Yaqian,et al."Deficiency of cartilage oligomeric matrix protein causes dilated cardiomyopathy".BASIC RESEARCH IN CARDIOLOGY 108.5(2013).
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