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学科主题: 临床医学
题名:
Flow-injection with enhanced chemiluminescence detection of ofloxacin in human plasma
作者: Zhang, XH; Jin, OY; Zhai, S; Huang, GM; Zha, HC
关键词: human plasma ; ofloxacin ; flow-injection ; chemiluminescence ; terbium(III) ; cerium(IV) ; sulphite
刊名: LUMINESCENCE
发表日期: 2005-07-01
DOI: 10.1002/bio.853
卷: 20, 期:4-5, 页:362-369
收录类别: ISTP ; SCI
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: FLUORESCENCE DETECTION ; PHARMACEUTICAL-PREPARATIONS ; CHICKEN TISSUES ; LEVOFLOXACIN ; URINE ; SERUM ; HPLC
英文摘要:

A simple, rapid and sensitive method for the determination of ofloxacin in plasma has been developed based on flow-injection analysis with enhanced chemiluminescence (CL) detection. This method employs the CL reaction of cerium(IV) and sulphite sensitized by a Tb(III)-ofloxacin complex. Plasma samples were deproteinized with acetonitrile before analysis. Under optimal conditions, the method allowed the quantitative analysis of ofloxacin in plasma over the range of 22.5-900 ng/mL with a detection limit of 7.5 ng/mL (3 sigma). The intra-day and inter-day precision was < 3.0% (n = 11) and < 7.0% (n = 3), respectively. The method was a convenient tool, rapid (20 s/analysis) and well suited for pharmacokinetics studies in which thousands of samples must be analysed daily. It was applied to pharmacokinetics studies of ofloxacin. Copyright (c) 2005 John Wiley & Sons, Ltd.

语种: 英语
WOS记录号: WOS:000232144800027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53532
Appears in Collections:北京大学第三临床医学院_药剂科_期刊论文

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作者单位: 1.Peking Univ, Peking Hosp 3, Dept Pharm, Beijing 100083, Peoples R China
2.Beijing Normal Univ, Dept Chem, Beijing 100088, Peoples R China
3.Tsing Hua Univ, Educ Minist, Key Lab Atom & Mol Nanosci, Dept Chem, Beijing 100084, Peoples R China

Recommended Citation:
Zhang, XH,Jin, OY,Zhai, S,et al. Flow-injection with enhanced chemiluminescence detection of ofloxacin in human plasma[J]. LUMINESCENCE,2005,20(4-5):362-369.
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