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Flow-injection with enhanced chemiluminescence detection of ofloxacin in human plasma
Zhang, XH; Jin, OY; Zhai, S; Huang, GM; Zha, HC
关键词Human Plasma Ofloxacin Flow-injection Chemiluminescence Terbium(Iii) Cerium(Iv) Sulphite
刊名LUMINESCENCE
2005-07-01
DOI10.1002/bio.853
20期:4-5页:362-369
收录类别ISTP ; SCI
文章类型Proceedings Paper
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]FLUORESCENCE DETECTION ; PHARMACEUTICAL-PREPARATIONS ; CHICKEN TISSUES ; LEVOFLOXACIN ; URINE ; SERUM ; HPLC
英文摘要

A simple, rapid and sensitive method for the determination of ofloxacin in plasma has been developed based on flow-injection analysis with enhanced chemiluminescence (CL) detection. This method employs the CL reaction of cerium(IV) and sulphite sensitized by a Tb(III)-ofloxacin complex. Plasma samples were deproteinized with acetonitrile before analysis. Under optimal conditions, the method allowed the quantitative analysis of ofloxacin in plasma over the range of 22.5-900 ng/mL with a detection limit of 7.5 ng/mL (3 sigma). The intra-day and inter-day precision was < 3.0% (n = 11) and < 7.0% (n = 3), respectively. The method was a convenient tool, rapid (20 s/analysis) and well suited for pharmacokinetics studies in which thousands of samples must be analysed daily. It was applied to pharmacokinetics studies of ofloxacin. Copyright (c) 2005 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000232144800027
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53532
专题北京大学第三临床医学院_药剂科
作者单位1.Peking Univ, Peking Hosp 3, Dept Pharm, Beijing 100083, Peoples R China
2.Beijing Normal Univ, Dept Chem, Beijing 100088, Peoples R China
3.Tsing Hua Univ, Educ Minist, Key Lab Atom & Mol Nanosci, Dept Chem, Beijing 100084, Peoples R China
推荐引用方式
GB/T 7714
Zhang, XH,Jin, OY,Zhai, S,et al. Flow-injection with enhanced chemiluminescence detection of ofloxacin in human plasma[J]. LUMINESCENCE,2005,20(4-5):362-369.
APA Zhang, XH,Jin, OY,Zhai, S,Huang, GM,&Zha, HC.(2005).Flow-injection with enhanced chemiluminescence detection of ofloxacin in human plasma.LUMINESCENCE,20(4-5),362-369.
MLA Zhang, XH,et al."Flow-injection with enhanced chemiluminescence detection of ofloxacin in human plasma".LUMINESCENCE 20.4-5(2005):362-369.
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