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学科主题基础医学
Pax6 directly modulate Sox2 expression in the neural progenitor cells
Wen, Jinhua1; Hu, Qikuan1,2; Li, Meiyu1; Wang, Shuling1; Zhang, Lirong1; Chen, Yuanyuan1; Li, Lingsong1
关键词Neural Progenitor Cells Pax6 Proliferation Sox2 Subventricular Zone
刊名NEUROREPORT
2008-03-05
19期:4页:413-417
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]GENE-EXPRESSION ; STEM-CELLS ; SPECIFICATION ; NEUROGENESIS ; NEOCORTEX ; EMBRYO ; ADULT
英文摘要

Pax6 is a key regulator in the neuronal fate determination as well as the proliferation of neural stem cells, but the mechanisms are still unknown. Our study shows that Pax6 regulate the proliferation of neural progenitor cells of cortical subventricular zone, through direct modulation of the Sox2 expression during the late developmental stage in mice. We found a dramatic decrease in the number of Sox2(+) neural progenitor cells in the subventricular zone of E18.5 Pax6(-/-) mice. We confirmed that Pax6 could bind to the Sox2 promoter by chromatin immunoprecipitation assay and activate Sox2 expression by a luciferase reporter gene assay. Moreover, neural progenitors isolated from the Pax6(-/-) embryos showed a decreased neurosphere formation as well as proliferation.

语种英语
WOS记录号WOS:000253884900005
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被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53543
专题北京大学基础医学院_细胞生物学系
北京大学基础医学院
北京大学第二临床医学院_心血管内科
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Peking Univ Stem Cell Res Ctr, Beijing 100083, Peoples R China
2.Ningxia Med Coll, Brain Res Lab Ningxia, Yinchuan, Peoples R China
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GB/T 7714
Wen, Jinhua,Hu, Qikuan,Li, Meiyu,et al. Pax6 directly modulate Sox2 expression in the neural progenitor cells[J]. NEUROREPORT,2008,19(4):413-417.
APA Wen, Jinhua.,Hu, Qikuan.,Li, Meiyu.,Wang, Shuling.,Zhang, Lirong.,...&Li, Lingsong.(2008).Pax6 directly modulate Sox2 expression in the neural progenitor cells.NEUROREPORT,19(4),413-417.
MLA Wen, Jinhua,et al."Pax6 directly modulate Sox2 expression in the neural progenitor cells".NEUROREPORT 19.4(2008):413-417.
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