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学科主题: 基础医学
题名:
Pax6 directly modulate Sox2 expression in the neural progenitor cells
作者: Wen, Jinhua1; Hu, Qikuan1,2; Li, Meiyu1; Wang, Shuling1; Zhang, Lirong1; Chen, Yuanyuan1; Li, Lingsong1
关键词: neural progenitor cells ; Pax6 ; proliferation ; Sox2 ; subventricular zone
刊名: NEUROREPORT
发表日期: 2008-03-05
卷: 19, 期:4, 页:413-417
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: GENE-EXPRESSION ; STEM-CELLS ; SPECIFICATION ; NEUROGENESIS ; NEOCORTEX ; EMBRYO ; ADULT
英文摘要:

Pax6 is a key regulator in the neuronal fate determination as well as the proliferation of neural stem cells, but the mechanisms are still unknown. Our study shows that Pax6 regulate the proliferation of neural progenitor cells of cortical subventricular zone, through direct modulation of the Sox2 expression during the late developmental stage in mice. We found a dramatic decrease in the number of Sox2(+) neural progenitor cells in the subventricular zone of E18.5 Pax6(-/-) mice. We confirmed that Pax6 could bind to the Sox2 promoter by chromatin immunoprecipitation assay and activate Sox2 expression by a luciferase reporter gene assay. Moreover, neural progenitors isolated from the Pax6(-/-) embryos showed a decreased neurosphere formation as well as proliferation.

语种: 英语
WOS记录号: WOS:000253884900005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53543
Appears in Collections:基础医学院_细胞生物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Peking Univ Stem Cell Res Ctr, Beijing 100083, Peoples R China
2.Ningxia Med Coll, Brain Res Lab Ningxia, Yinchuan, Peoples R China

Recommended Citation:
Wen, Jinhua,Hu, Qikuan,Li, Meiyu,et al. Pax6 directly modulate Sox2 expression in the neural progenitor cells[J]. NEUROREPORT,2008,19(4):413-417.
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