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Lymphovascular invasion in rectal cancer following neoadjuvant radiotherapy: A retrospective cohort study
Du, Chang-Zheng1; Xue, Wei-Cheng2; Cai, Yong3; Li, Ming1; Gu, Jin1
关键词Lymphovascular Invasion Rectal Cancer Neoadjuvant Radiotherapy Total Mesorectal Excision Pathology Prognosis
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2009-08-14
DOI10.3748/wjg.15.3793
15期:30页:3793-3798
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
资助者Peking University School of Oncology ; Peking University School of Oncology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]DISEASE-FREE SURVIVAL ; PREOPERATIVE RADIOTHERAPY ; COLORECTAL-CANCER ; RADIATION ; CHEMORADIATION ; RECURRENCE ; MECHANISM ; CARCINOMA ; THERAPY ; DAMAGE
英文摘要

AIM: To investigate the meaning of lymphovascular invasion (LVI) in rectal cancer after neoadjuvant radiotherapy.

METHODS: A total of 325 patients who underwent radical resection using total mesorectal excision (TME) from January 2000 to January 2005 in Beijing cancer hospital were included retrospectively, divided into a preoperative radiotherapy (PRT) group and a control group, according to whether or not they underwent preoperative radiation. Histological assessments of tumor specimens were made and the correlation of LVI and prognosis were evaluated by univariate and multivariate analysis.

RESULTS: The occurrence of LVI in the PRT and control groups was 21.4% and 26.1% respectively. In the control group, LVI was significantly associated with histological differentiation and pathologic TNM stage, whereas these associations were not observed in the PRT group. LVI was closely correlated to disease progression and 5-year overall survival (OS) in both groups. Among the patients with disease progression, LVI positive patients in the PRT group had a significantly longer median disease-free period (22.5 mo vs 11.5 mo, P = 0.023) and overall survival time (42.5 mo vs 26.5 mo, P = 0.035) compared to those in the control group, despite the fact that no significant difference in 5-year OS rate was observed (54.4% vs 48.3%, P = 0.137). Multivariate analysis showed the distance of tumor from the anal verge, pretreatment serum carcinoembryonic antigen level, pathologic TNM stage and LVI were the major factors affecting OS.

CONCLUSION: Neoadjuvant radiotherapy does not reduce LVI significantly; however, the prognostic meaning of LVI has changed. Patients with LVI may benefit from neoadjuvant radiotherapy. (C) 2009 The WJG Press and Baishideng. All rights reserved.

语种英语
资助者Peking University School of Oncology ; Peking University School of Oncology
WOS记录号WOS:000269003300012
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53544
专题北京大学临床肿瘤学院_胃肠肿瘤中心
作者单位1.Peking Univ, Sch Oncol, Dept Colorectal Surg, Beijing 100142, Peoples R China
2.Peking Univ, Sch Oncol, Dept Pathol, Beijing 100142, Peoples R China
3.Peking Univ, Sch Oncol, Dept Radiotherapy, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Du, Chang-Zheng,Xue, Wei-Cheng,Cai, Yong,et al. Lymphovascular invasion in rectal cancer following neoadjuvant radiotherapy: A retrospective cohort study[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2009,15(30):3793-3798.
APA Du, Chang-Zheng,Xue, Wei-Cheng,Cai, Yong,Li, Ming,&Gu, Jin.(2009).Lymphovascular invasion in rectal cancer following neoadjuvant radiotherapy: A retrospective cohort study.WORLD JOURNAL OF GASTROENTEROLOGY,15(30),3793-3798.
MLA Du, Chang-Zheng,et al."Lymphovascular invasion in rectal cancer following neoadjuvant radiotherapy: A retrospective cohort study".WORLD JOURNAL OF GASTROENTEROLOGY 15.30(2009):3793-3798.
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