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学科主题: 基础医学
题名:
Protein tyrosine phosphatase interacting protein 51 (PTPIP51) is a novel mitochondria protein with an N-terminal mitochondrial targeting sequence and induces apoptosis
作者: Lv, B. F.; Yu, C. F.; Chen, Y. Y.; Lu, Y.; Guo, J. H.; Song, Q. S.; Ma, D. L.; Shi, T. P.; Wang, L.
关键词: apoptosis ; mitochondria ; caspase-3 ; FLJ10579 ; protein tyrosine phosphatase interacting protein 51 (PTPIP51) ; transmembrane (TM) domain
刊名: APOPTOSIS
发表日期: 2006-09-01
DOI: 10.1007/s10495-006-8882-9
卷: 11, 期:9, 页:1489-1501
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]: CYTOCHROME-C RELEASE ; DEATH ; CELL ; FISSION ; SIGNAL ; BCL-2 ; OVEREXPRESSION ; ACTIVATION ; RECEPTORS ; MEMBRANE
英文摘要:

Apoptosis is a genetically determined cell suicide program. Mitochondria play a central role in this process and various molecules have been shown to regulate apoptosis in this organelle. In the present study, we firstly identified that protein tyrosine phosphatase interacting protein 51 (PTPIP51) is a novel mitochondrial protein, which may induce apoptosis in HEK293T and HeLa cell lines. PTPIP51 transfection resulted in the externalization of phosphatidylserine (PS), activation of caspase-3, cleavage of PARP, and condensation of nuclear DNA. Further investigation revealed that PTPIP51 over-expression caused a decrease in mitochondrial membrane potential and release of cytochrome c, suggesting that it may be involved in a mitochondria/cytochrome c mediated apoptosis pathway. We also found that a putative TM domain near the N terminus of PTPIP51 is required for its targeting to mitochondria, as evidenced by the finding that deletion of the PTPIP51 TM domain prevented the protein′s mitochondiral localization. Furthermore, this deletion significantly influenced the ability of PTPIP51 to induce apoptosis. Taken together, the results of the present study suggest that PTPIP51 is a mitochondrial protein with apoptosis-inducing function and that the N-terminal TM domain is required for both the correct targeting of the protein to mitochondria and its apoptotic functions.

语种: 英语
WOS记录号: WOS:000239886700003
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53550
Appears in Collections:基础医学院_北京大学人类疾病基因研究中心_期刊论文

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作者单位: 1.Chinese Natl Human Genome Ctr, Beijing 100176, Peoples R China
2.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Lab Med Immunol, Sch Basic Med Sci, Beijing 100083, Peoples R China

Recommended Citation:
Lv, B. F.,Yu, C. F.,Chen, Y. Y.,et al. Protein tyrosine phosphatase interacting protein 51 (PTPIP51) is a novel mitochondria protein with an N-terminal mitochondrial targeting sequence and induces apoptosis[J]. APOPTOSIS,2006,11(9):1489-1501.
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