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学科主题: 口腔医学
题名:
GFA Taq I polymorphism and cleft lip with or without cleft palate (CL/P) risk
作者: Dong, Lijia; Ma, Lian
关键词: Transforming growth factor alpha ; genetics ; cleft lip with or without cleft palate ; meta-analysis
刊名: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
发表日期: 2015
卷: 8, 期:3, 页:3545-3551
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: GROWTH-FACTOR-ALPHA ; GENETIC-VARIATION ; ORAL CLEFTS ; MATERNAL SMOKING ; TGF-ALPHA ; ASSOCIATION ; LOCUS ; POPULATION ; ETIOLOGY ; MARYLAND
英文摘要:

The transforming growth factor alpha (TGFA) Taq I polymorphism has been indicated to be correlated with cleft lip with or without cleft palate (CL/P) susceptibility, but study results are still debatable. Thus, a meta-analysis was conducted. We conducted a comprehensive search of Embase, Ovid, Web of Science, the Cochrane database, PubMed, the Chinese Biomedical Literature Database (CBM-disc, 1979-2014), the database of National Knowledge Infrastructure (CNKI, 1979-2014) and the full paper database of Chinese Science and Technology of Chongqing (VIP, 1989-2014) to identify suitable studies. There were 18 studies suitable for this meta-analysis, involving a total of 3135 cases and 3575 controls. Significantly increased CL/P risk was observed (OR = 1.49; 95% CI 1.17-1.89; P = 0.001). In subgroup analyses stratified by ethnicity, there was evidence in the Caucasian population for an association between this polymorphism and CL/P risk (OR = 1.52; 95% CI 1.14-2.02; P = 0.004). However, no significant association was found between this his polymorphism and CL/P risk in African and Hispanic populations. According to a specific CL/P type, increased clip lip and palate risk and clip palate risk were found (OR = 1.38; 95% CI 1.10-1.73; P = 0.005; OR = 1.29; 95% CI 1.01-1.66; P = 0.042). In conclusion, the present meta-analysis found that the TGFA Taq I polymorphism may be associated with CL/P susceptibility.

语种: 英语
WOS记录号: WOS:000355307300052
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53553
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: Peking Univ, Dept Oral & Maxillofacial Surg, Cleft Lip & Palate Ctr, Sch Stomatol, Beijing 100081, Peoples R China

Recommended Citation:
Dong, Lijia,Ma, Lian. GFA Taq I polymorphism and cleft lip with or without cleft palate (CL/P) risk[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2015,8(3):3545-3551.
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