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GFA Taq I polymorphism and cleft lip with or without cleft palate (CL/P) risk
Dong, Lijia; Ma, Lian
关键词Transforming Growth Factor Alpha Genetics Cleft Lip With Or Without Cleft Palate Meta-analysis
刊名INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
2015
8期:3页:3545-3551
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]GROWTH-FACTOR-ALPHA ; GENETIC-VARIATION ; ORAL CLEFTS ; MATERNAL SMOKING ; TGF-ALPHA ; ASSOCIATION ; LOCUS ; POPULATION ; ETIOLOGY ; MARYLAND
英文摘要

The transforming growth factor alpha (TGFA) Taq I polymorphism has been indicated to be correlated with cleft lip with or without cleft palate (CL/P) susceptibility, but study results are still debatable. Thus, a meta-analysis was conducted. We conducted a comprehensive search of Embase, Ovid, Web of Science, the Cochrane database, PubMed, the Chinese Biomedical Literature Database (CBM-disc, 1979-2014), the database of National Knowledge Infrastructure (CNKI, 1979-2014) and the full paper database of Chinese Science and Technology of Chongqing (VIP, 1989-2014) to identify suitable studies. There were 18 studies suitable for this meta-analysis, involving a total of 3135 cases and 3575 controls. Significantly increased CL/P risk was observed (OR = 1.49; 95% CI 1.17-1.89; P = 0.001). In subgroup analyses stratified by ethnicity, there was evidence in the Caucasian population for an association between this polymorphism and CL/P risk (OR = 1.52; 95% CI 1.14-2.02; P = 0.004). However, no significant association was found between this his polymorphism and CL/P risk in African and Hispanic populations. According to a specific CL/P type, increased clip lip and palate risk and clip palate risk were found (OR = 1.38; 95% CI 1.10-1.73; P = 0.005; OR = 1.29; 95% CI 1.01-1.66; P = 0.042). In conclusion, the present meta-analysis found that the TGFA Taq I polymorphism may be associated with CL/P susceptibility.

语种英语
WOS记录号WOS:000355307300052
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53553
专题北京大学口腔医学院
北京大学口腔医学院_外科
作者单位Peking Univ, Dept Oral & Maxillofacial Surg, Cleft Lip & Palate Ctr, Sch Stomatol, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Dong, Lijia,Ma, Lian. GFA Taq I polymorphism and cleft lip with or without cleft palate (CL/P) risk[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2015,8(3):3545-3551.
APA Dong, Lijia,&Ma, Lian.(2015).GFA Taq I polymorphism and cleft lip with or without cleft palate (CL/P) risk.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,8(3),3545-3551.
MLA Dong, Lijia,et al."GFA Taq I polymorphism and cleft lip with or without cleft palate (CL/P) risk".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 8.3(2015):3545-3551.
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