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Analysis of risk factors affecting the prognosis of pancreatic neuroendocrine tumors
Tao Ming1; Yuan Chunhui1; Xiu Dianrong1; Shi Xueying2; Tao Liyuan3; Ma Zhaolai1; Jiang Bin1; Zhang Zhipeng1; Zhang Lingfu1; Wang Hangyan1
关键词Tumor Marker Risk Factors Nerve Invasion Prognosis Pancreatic Neuroendocrine Tumors
刊名CHINESE MEDICAL JOURNAL
2014-08-20
DOI10.3760/cma.j.issn.0366-6999.20132104
127期:16页:2924-2928
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
资助者Doctoral Fund of the Ministry Education of China ; Doctoral Fund of the Ministry Education of China
研究领域[WOS]General & Internal Medicine
关键词[WOS]ENDOCRINE TUMORS ; SURGICAL-TREATMENT ; CARCINOID-TUMOR ; PHASE-II ; OCTREOTIDE ; SIZE ; CLASSIFICATION ; MULTICENTER ; METASTASES ; SYSTEM
英文摘要

Background Pancreatic neuroendocrine tumors (pNETs) are a type of tumors with the characteristics of easy metastasis and recurrence. Till date, the risk factors affecting the prognosis are still in the debate. In this study, several risk factors will be discussed combined with our cases and experience.

Methods Thirty-three patients diagnosed as pNETs were enrolled and the clinical features, blood tests, pathological features, surgical treatment, and follow-up data of these patients were collected and analyzed.

Results In this study, operation time of G3 cases was longer than G1/G2 cases (P=0.017). The elevated level of tumor markers such as AFP, CEA, Ca125, and Ca19-9 may predict easier metastasis, earlier recurrence, and poor prognosis (P=0.007). The presence of cancer embolus and nerve invasion increases along with the TNM stage (P=0.037 and P=0.040), and the incidence of positive surgical margin increased (P=0.007). When the presence of nerve invasion occurs, the chance of cancer embolus and lymph node metastasis also increases (P=0.016 and P=0.026).

Conclusions pNETs were tumors with the features of easy recurrence and metastasis and many risk factors could affect its prognosis such as the elevated levels of tumor markers and the presence of nerve invasion, except some recognized risk factors. If one or more of these factors existed, postoperative treatments may be needed to improve prognosis.

语种英语
所属项目编号20090001110096
资助者Doctoral Fund of the Ministry Education of China ; Doctoral Fund of the Ministry Education of China
WOS记录号WOS:000347491900009
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53556
专题北京大学第三临床医学院_普通外科
作者单位1.Peking Univ, Hosp 3, Dept Gen Surg, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 3, Res Ctr Clin Epidemiol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Tao Ming,Yuan Chunhui,Xiu Dianrong,et al. Analysis of risk factors affecting the prognosis of pancreatic neuroendocrine tumors[J]. CHINESE MEDICAL JOURNAL,2014,127(16):2924-2928.
APA Tao Ming.,Yuan Chunhui.,Xiu Dianrong.,Shi Xueying.,Tao Liyuan.,...&Wang Hangyan.(2014).Analysis of risk factors affecting the prognosis of pancreatic neuroendocrine tumors.CHINESE MEDICAL JOURNAL,127(16),2924-2928.
MLA Tao Ming,et al."Analysis of risk factors affecting the prognosis of pancreatic neuroendocrine tumors".CHINESE MEDICAL JOURNAL 127.16(2014):2924-2928.
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