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Smoothened gene alterations in keratocystic odontogenic tumors
Zhang Rui1; Peng Li-Ying1; Qu Jia-Fei1; Hong Ying-Ying1; Chen Feng2; Li Tie-Jun1
关键词Keratocystic Odontogenic Tumor (Kcot) Hedgehog (Hh) Signaling Pathway Gene Mutation Smo Gene
刊名HEAD & FACE MEDICINE
2014-09-05
DOI10.1186/1746-160X-10-36
10
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]CELL CARCINOMA SYNDROME ; HEDGEHOG SIGNALING PATHWAY ; THERAPEUTIC TARGET ; PTCH1 GENE ; MUTATIONS ; CANCER ; SMO ; RECEPTOR ; PROTEIN ; ENCODES
英文摘要

Background: It has been widely demonstrated that the hedgehog pathway is strongly associated with basal cell carcinoma of the skin (NBCCS). To assess potential DNA alterations related to keratocystic odontogenic tumors (KCOTs), we sequenced smoothened (SMO) genes in 12 sporadic KCOTs.

Methods: Polymerase chain reaction (PCR), capillary electrophoresis and dideoxy chain-termination sequencing were used to examine potential DNA alterations in sporadic KCOTs.

Results: Five alterations in SMO genes were detected. Four of these mutations consisted of two synonymous and three missense mutations; two of which have not been reported to date (c.T776A, c.T1281G).

Conclusions: SMO genes may play an important role in the sonic hedgehog (SHH) pathway and could also be responsible for generating KCOTs and NBCCS. However, their influence on SHH signaling remains to be elucidated.

语种英语
WOS记录号WOS:000341734900001
项目编号81030018 ; 30872900 ; 81200762
资助机构National Natural Science Foundation of China
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53557
专题北京大学口腔医学院_口腔病理科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Zhang Rui,Peng Li-Ying,Qu Jia-Fei,et al. Smoothened gene alterations in keratocystic odontogenic tumors[J]. HEAD & FACE MEDICINE,2014,10.
APA Zhang Rui,Peng Li-Ying,Qu Jia-Fei,Hong Ying-Ying,Chen Feng,&Li Tie-Jun.(2014).Smoothened gene alterations in keratocystic odontogenic tumors.HEAD & FACE MEDICINE,10.
MLA Zhang Rui,et al."Smoothened gene alterations in keratocystic odontogenic tumors".HEAD & FACE MEDICINE 10(2014).
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