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学科主题: 口腔医学
题名:
Smoothened gene alterations in keratocystic odontogenic tumors
作者: Zhang Rui1; Peng Li-Ying1; Qu Jia-Fei1; Hong Ying-Ying1; Chen Feng2; Li Tie-Jun1
关键词: Keratocystic odontogenic tumor (KCOT) ; Hedgehog (HH) signaling pathway ; Gene mutation ; SMO gene
刊名: HEAD & FACE MEDICINE
发表日期: 2014-09-05
DOI: 10.1186/1746-160X-10-36
卷: 10
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: CELL CARCINOMA SYNDROME ; HEDGEHOG SIGNALING PATHWAY ; THERAPEUTIC TARGET ; PTCH1 GENE ; MUTATIONS ; CANCER ; SMO ; RECEPTOR ; PROTEIN ; ENCODES
英文摘要:

Background: It has been widely demonstrated that the hedgehog pathway is strongly associated with basal cell carcinoma of the skin (NBCCS). To assess potential DNA alterations related to keratocystic odontogenic tumors (KCOTs), we sequenced smoothened (SMO) genes in 12 sporadic KCOTs.

Methods: Polymerase chain reaction (PCR), capillary electrophoresis and dideoxy chain-termination sequencing were used to examine potential DNA alterations in sporadic KCOTs.

Results: Five alterations in SMO genes were detected. Four of these mutations consisted of two synonymous and three missense mutations; two of which have not been reported to date (c.T776A, c.T1281G).

Conclusions: SMO genes may play an important role in the sonic hedgehog (SHH) pathway and could also be responsible for generating KCOTs and NBCCS. However, their influence on SHH signaling remains to be elucidated.

语种: 英语
所属项目编号: 81030018 ; 30872900 ; 81200762
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000341734900001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53557
Appears in Collections:北京大学口腔医学院_口腔病理科_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Cent Lab, Beijing 100081, Peoples R China

Recommended Citation:
Zhang Rui,Peng Li-Ying,Qu Jia-Fei,et al. Smoothened gene alterations in keratocystic odontogenic tumors[J]. HEAD & FACE MEDICINE,2014,10.
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