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The TGF-beta 1/Smad/CTGF Pathway and Corpus Cavernosum Fibrous-Muscular Alterations in Rats With Streptozotocin-Induced Diabetes
Zhou, Feng; Li, Guang-Yong; Gao, Zhe-Zhu; Liu, Jing; Liu, Tao; Li, We-Ren; Cui, Wan-Shou; Bai, Guang-Yi; Xin, Zhong-Cheng
关键词Erectile Dysfunction Collagen Fibers Elastic Fibers Connective Tissue Growth Factor Transforming Growth Factor Beta Smad
刊名JOURNAL OF ANDROLOGY
2012-07-01
DOI10.2164/jandrol.111.014456
33期:4页:651-659
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Andrology
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]TISSUE GROWTH-FACTOR ; ERECTILE DYSFUNCTION ; ENDOTHELIAL-CELLS ; PENILE FIBROSIS ; SMOOTH-MUSCLE ; EXPRESSION ; MEN ; IMPOTENCE ; BLADDER ; GENES
英文摘要

Diabetes-associated erectile dysfunction is associated with increased extracellular matrix deposition and reduced smooth muscle content in the corpus cavernosum. The mechanisms of these processes are not well understood. In this study, we investigated fibromuscular changes in the corpus cavernosum of rats with streptozotocin-induced diabetes to determine the mechanisms underlying pathologic changes in penile structure and function. Forty 8-week-old Sprague-Dawley rats were randomly distributed into control and diabetic groups. Diabetes was induced by a one-time intraperitoneal injection of streptozotocin 60 mg/kg. Twelve weeks later, erectile function was measured by cavernous nerve electrostimulation with real-time intracorporal pressure assessment. The penis was harvested for histologic examination (Masson trichrome stain, picrosirius red stain, Hart elastin stain, terminal deoxynucleotidyl transferase mediated dUTP nick-end labeling, and immunohistochemistry) and Western blot. Diabetes significantly attenuated erectile response to cavernous nerve electrostimulation. Diabetic animals exhibited a decreased smooth muscle/collagen ratio in the corpus cavernosum. The ratio of collagen I to II fibers was significantly lower in the corpora of diabetic rats compared with controls. Cavernous elastic fibers were fragmented in diabetic rats. There was up-regulation of the transforming growth factor beta 1/Smad/connective tissue growth factor signaling pathway in diabetic rats. Phospho-Smad2 expression was higher in smooth muscle cells and fibroblasts of diabetic rats, as was the apoptotic index. The up-regulation of the transforming growth factor beta 1/Smad/connective tissue growth factor signaling pathway might play an important role in diabetes-induced fibrous-muscular structural changes and deterioration of erectile function.

语种英语
WOS记录号WOS:000306635600021
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53559
专题北京大学第一临床医学院_男科中心
作者单位Peking Univ, Androl Ctr, Hosp 1, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Feng,Li, Guang-Yong,Gao, Zhe-Zhu,et al. The TGF-beta 1/Smad/CTGF Pathway and Corpus Cavernosum Fibrous-Muscular Alterations in Rats With Streptozotocin-Induced Diabetes[J]. JOURNAL OF ANDROLOGY,2012,33(4):651-659.
APA Zhou, Feng.,Li, Guang-Yong.,Gao, Zhe-Zhu.,Liu, Jing.,Liu, Tao.,...&Xin, Zhong-Cheng.(2012).The TGF-beta 1/Smad/CTGF Pathway and Corpus Cavernosum Fibrous-Muscular Alterations in Rats With Streptozotocin-Induced Diabetes.JOURNAL OF ANDROLOGY,33(4),651-659.
MLA Zhou, Feng,et al."The TGF-beta 1/Smad/CTGF Pathway and Corpus Cavernosum Fibrous-Muscular Alterations in Rats With Streptozotocin-Induced Diabetes".JOURNAL OF ANDROLOGY 33.4(2012):651-659.
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