IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Efficacy of 1% carboxymethylcellulose sodium for treating dry eye after phacoemulsification: results from a multicenter, open-label, randomized, controlled study
Yao, Ke1; Bao, Yongzhen2; Ye, Jian3; Lu, Yi4; Bi, Hongsheng5; Tang, Xin6; Zhao, Yune7; Zhang, Jinsong8; Yang, Jinling9
关键词Carboxymethylcellulose Dry Eye Phacoemulsification Cataract Surgery
刊名BMC Ophthalmology
2015-03-20
DOI10.1186/s12886-015-0005-3
15
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]CATARACT-SURGERY ; MEIBOMIAN GLAND ; OCULAR-SURFACE ; WORKSHOP 2007 ; DISEASE ; SUBCOMMITTEE ; CLASSIFICATION
英文摘要

Background: For patients who experience dry eye after phacoemulsification, vision and quality of life can significantly deteriorate. In this study, the efficacy and safety of carboxymethylcellulose sodium (CMC) 1% ophthalmic solution combined with conventional therapy in treating dry eye signs and symptoms after phacoemulsification were evaluated.

Methods: In this prospective, multicenter, open-label, controlled study, 180 patients with age-related cataract were randomized to treatment with conventional therapy plus CMC 1% (n = 90) or to conventional therapy only (control group, n = 90) after phacoemulsification and intraocular lens implantation. Tear breakup time (TBUT), the Schirmer test with anesthesia, and fluorescein and lissamine green staining were performed. The Ocular Surface Disease Index (OSDI) questionnaire and a patient subjective symptom evaluation were administered preoperatively (baseline) and postoperatively at 7 and 30 days.

Results: TBUT was significantly longer in the treatment group compared with the control group at day 7 (8.5 +/- 5.5 versus 6.6 +/- 3.8 s; P = 0.0475) and day 30 (9.0 +/- 5.9 versus 6.7 +/- 4.8 s; P = 0.0258) after surgery. Compared with baseline, TBUT significantly increased in patients in the treatment group (P < 0.001 at both day 7 and day 30) with a presurgical diagnosis of dry eye, but significantly decreased in patients in the control group (P < 0.02 at both day 7 and day 30) with no prior diagnosis of dry eye. Fluorescein and lissamine staining, OSDI questionnaire and subjective symptom scores all improved from baseline, with no significant differences between the two groups. No significant differences in tolerability and safety were observed between the group receiving CMC and conventional therapy, and those receiving conventional therapy only.

Conclusion: Treatment with CMC 1% can provide significant improvement in tear film stability after phacoemulsification for age-related cataract.

语种英语
WOS记录号WOS:000353318500001
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53562
Collection北京大学第二临床医学院
作者单位1.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Eye Ctr, Hangzhou 310003, Zhejiang, Peoples R China
2.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China
3.Third Mil Med Univ, Daping Hosp, Chongqing, Peoples R China
4.Fudan Univ, Eye Ear Nose & Throat Hosp, Shanghai 200433, Peoples R China
5.Shandong Shierming Eye Hosp, Jinan, Peoples R China
6.Tianjin Eye Hosp, Tianjin, Peoples R China
7.Wenzhou Med Coll, Affiliated Eye Hosp, Wenzhou, Peoples R China
8.China Med Univ, Affiliated Hosp 4, Shenyang 110001, Peoples R China
9.Allergan Informat Consulting Shanghai Co Ltd, Shanghai, Peoples R China
Recommended Citation
GB/T 7714
Yao, Ke,Bao, Yongzhen,Ye, Jian,et al. Efficacy of 1% carboxymethylcellulose sodium for treating dry eye after phacoemulsification: results from a multicenter, open-label, randomized, controlled study[J]. BMC Ophthalmology,2015,15.
APA Yao, Ke.,Bao, Yongzhen.,Ye, Jian.,Lu, Yi.,Bi, Hongsheng.,...&Yang, Jinling.(2015).Efficacy of 1% carboxymethylcellulose sodium for treating dry eye after phacoemulsification: results from a multicenter, open-label, randomized, controlled study.BMC Ophthalmology,15.
MLA Yao, Ke,et al."Efficacy of 1% carboxymethylcellulose sodium for treating dry eye after phacoemulsification: results from a multicenter, open-label, randomized, controlled study".BMC Ophthalmology 15(2015).
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