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学科主题: 临床医学
题名:
Efficacy of 1% carboxymethylcellulose sodium for treating dry eye after phacoemulsification: results from a multicenter, open-label, randomized, controlled study
作者: Yao, Ke1; Bao, Yongzhen2; Ye, Jian3; Lu, Yi4; Bi, Hongsheng5; Tang, Xin6; Zhao, Yune7; Zhang, Jinsong8; Yang, Jinling9
关键词: Carboxymethylcellulose ; Dry eye ; Phacoemulsification ; Cataract surgery
刊名: BMC Ophthalmology
发表日期: 2015-03-20
DOI: 10.1186/s12886-015-0005-3
卷: 15
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: CATARACT-SURGERY ; MEIBOMIAN GLAND ; OCULAR-SURFACE ; WORKSHOP 2007 ; DISEASE ; SUBCOMMITTEE ; CLASSIFICATION
英文摘要:

Background: For patients who experience dry eye after phacoemulsification, vision and quality of life can significantly deteriorate. In this study, the efficacy and safety of carboxymethylcellulose sodium (CMC) 1% ophthalmic solution combined with conventional therapy in treating dry eye signs and symptoms after phacoemulsification were evaluated.

Methods: In this prospective, multicenter, open-label, controlled study, 180 patients with age-related cataract were randomized to treatment with conventional therapy plus CMC 1% (n = 90) or to conventional therapy only (control group, n = 90) after phacoemulsification and intraocular lens implantation. Tear breakup time (TBUT), the Schirmer test with anesthesia, and fluorescein and lissamine green staining were performed. The Ocular Surface Disease Index (OSDI) questionnaire and a patient subjective symptom evaluation were administered preoperatively (baseline) and postoperatively at 7 and 30 days.

Results: TBUT was significantly longer in the treatment group compared with the control group at day 7 (8.5 +/- 5.5 versus 6.6 +/- 3.8 s; P = 0.0475) and day 30 (9.0 +/- 5.9 versus 6.7 +/- 4.8 s; P = 0.0258) after surgery. Compared with baseline, TBUT significantly increased in patients in the treatment group (P < 0.001 at both day 7 and day 30) with a presurgical diagnosis of dry eye, but significantly decreased in patients in the control group (P < 0.02 at both day 7 and day 30) with no prior diagnosis of dry eye. Fluorescein and lissamine staining, OSDI questionnaire and subjective symptom scores all improved from baseline, with no significant differences between the two groups. No significant differences in tolerability and safety were observed between the group receiving CMC and conventional therapy, and those receiving conventional therapy only.

Conclusion: Treatment with CMC 1% can provide significant improvement in tear film stability after phacoemulsification for age-related cataract.

语种: 英语
项目资助者: Allergan Information Consulting (Shanghai) Co, Ltd, Shanghai, China ; Allergan Inc., Irvine, CA
WOS记录号: WOS:000353318500001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53562
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Eye Ctr, Hangzhou 310003, Zhejiang, Peoples R China
2.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China
3.Third Mil Med Univ, Daping Hosp, Chongqing, Peoples R China
4.Fudan Univ, Eye Ear Nose & Throat Hosp, Shanghai 200433, Peoples R China
5.Shandong Shierming Eye Hosp, Jinan, Peoples R China
6.Tianjin Eye Hosp, Tianjin, Peoples R China
7.Wenzhou Med Coll, Affiliated Eye Hosp, Wenzhou, Peoples R China
8.China Med Univ, Affiliated Hosp 4, Shenyang 110001, Peoples R China
9.Allergan Informat Consulting Shanghai Co Ltd, Shanghai, Peoples R China

Recommended Citation:
Yao, Ke,Bao, Yongzhen,Ye, Jian,et al. Efficacy of 1% carboxymethylcellulose sodium for treating dry eye after phacoemulsification: results from a multicenter, open-label, randomized, controlled study[J]. BMC Ophthalmology,2015,15.
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