北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学口腔医学院  > 牙周科  > 期刊论文
学科主题: 口腔医学
题名:
Porphyromonas gingivalis Infection-Associated Periodontal Bone Resorption Is Dependent on Receptor Activator of NF-kappa B Ligand
作者: Han, Xiaozhe1; Lin, Xiaoping1,2; Yu, Xiaoqian1,3,4; Lin, Jiang1,5; Kawai, Toshihisa1; LaRosa, Karen B.1; Taubman, Martin A.1
刊名: INFECTION AND IMMUNITY
发表日期: 2013-05-01
DOI: 10.1128/IAI.00043-13
卷: 81, 期:5, 页:1502-1509
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Infectious Diseases
研究领域[WOS]: Immunology ; Infectious Diseases
关键词[WOS]: T-CELLS ; OSTEOPROTEGERIN LIGAND ; IMMUNE-SYSTEM ; OSTEOCLAST DIFFERENTIATION ; LYMPHOCYTE DEVELOPMENT ; RHEUMATOID-ARTHRITIS ; POSTMENOPAUSAL WOMEN ; DISEASE ; OSTEOIMMUNOLOGY ; INDUCTION
英文摘要:

Porphyromonas gingivalis is one of the oral microorganisms associated with human chronic periodontitis. The purpose of this study is to determine the role of the receptor activator of nuclear factor-kappa B ligand (RANKL) in P. gingivalis infection-associated periodontal bone resorption. Inbred female Rowett rats were infected orally on four consecutive days (days 0 to 3) with 1 x 10(9) P. gingivalis bacteria (strain ATCC 33277). Separate groups of rats also received an injection of anti-RANKL antibody, osteoprotegerin fusion protein (OPG-Fc), or a control fusion protein (L6-Fc) into gingival papillae in addition to P. gingivalis infection. Robust serum IgG and salivary IgA antibody (P<0.01) and T cell proliferation (P<0.05) responses to P. gingivalis were detected at day 7 and peaked at day 28 in P. gingivalis-infected rats. Both the concentration of soluble RANKL (sRANKL) in rat gingival tissues (P<0.01) and periodontal bone resorption (P<0.05) were significantly elevated at day 28 in the P. gingivalis-infected group compared to levels in the uninfected group. Correspondingly, RANKL-expressing T and B cells in rat gingival tissues were significantly increased at day 28 in the P. gingivalis-infected group compared to the levels in the uninfected group (P<0.01). Injection of anti-RANKL antibody (P<0.05) or OPG-Fc (P<0.01), but not L6-Fc, into rat gingival papillae after P. gingivalis infection resulted in significantly reduced periodontal bone resorption. This study suggests that P. gingivalis infection-associated periodontal bone resorption is RANKL dependent and is accompanied by increased local infiltration of RANKL-expressing T and B cells.

语种: 英语
所属项目编号: DE-03420 ; DE-07327
项目资助者: NIH from the National Institute of Dental and Craniofacial Research
WOS记录号: WOS:000317582700013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53565
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Hosp Stomatol, Beijing, Peoples R China
2.Forsyth Inst, Dept Immunol & Infect Dis, Cambridge, MA USA
3.China Med Univ, Shengjing Hosp, Dept Stomatol, Shenyang, Liaoning Provin, Peoples R China
4.Peking Univ, Dept Periodontol, Sch Stomatol, Beijing 100871, Peoples R China
5.Harbin Med Univ, Coll 4, Dept Stomatol, Harbin, Peoples R China

Recommended Citation:
Han, Xiaozhe,Lin, Xiaoping,Yu, Xiaoqian,et al. Porphyromonas gingivalis Infection-Associated Periodontal Bone Resorption Is Dependent on Receptor Activator of NF-kappa B Ligand[J]. INFECTION AND IMMUNITY,2013,81(5):1502-1509.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Han, Xiaozhe]'s Articles
[Lin, Xiaoping]'s Articles
[Yu, Xiaoqian]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Han, Xiaozhe]‘s Articles
[Lin, Xiaoping]‘s Articles
[Yu, Xiaoqian]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace