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学科主题口腔医学
Porphyromonas gingivalis Infection-Associated Periodontal Bone Resorption Is Dependent on Receptor Activator of NF-kappa B Ligand
Han, Xiaozhe1; Lin, Xiaoping1,2; Yu, Xiaoqian1,3,4; Lin, Jiang1,5; Kawai, Toshihisa1; LaRosa, Karen B.1; Taubman, Martin A.1
刊名INFECTION AND IMMUNITY
2013-05-01
DOI10.1128/IAI.00043-13
81期:5页:1502-1509
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Infectious Diseases
研究领域[WOS]Immunology ; Infectious Diseases
关键词[WOS]T-CELLS ; OSTEOPROTEGERIN LIGAND ; IMMUNE-SYSTEM ; OSTEOCLAST DIFFERENTIATION ; LYMPHOCYTE DEVELOPMENT ; RHEUMATOID-ARTHRITIS ; POSTMENOPAUSAL WOMEN ; DISEASE ; OSTEOIMMUNOLOGY ; INDUCTION
英文摘要

Porphyromonas gingivalis is one of the oral microorganisms associated with human chronic periodontitis. The purpose of this study is to determine the role of the receptor activator of nuclear factor-kappa B ligand (RANKL) in P. gingivalis infection-associated periodontal bone resorption. Inbred female Rowett rats were infected orally on four consecutive days (days 0 to 3) with 1 x 10(9) P. gingivalis bacteria (strain ATCC 33277). Separate groups of rats also received an injection of anti-RANKL antibody, osteoprotegerin fusion protein (OPG-Fc), or a control fusion protein (L6-Fc) into gingival papillae in addition to P. gingivalis infection. Robust serum IgG and salivary IgA antibody (P<0.01) and T cell proliferation (P<0.05) responses to P. gingivalis were detected at day 7 and peaked at day 28 in P. gingivalis-infected rats. Both the concentration of soluble RANKL (sRANKL) in rat gingival tissues (P<0.01) and periodontal bone resorption (P<0.05) were significantly elevated at day 28 in the P. gingivalis-infected group compared to levels in the uninfected group. Correspondingly, RANKL-expressing T and B cells in rat gingival tissues were significantly increased at day 28 in the P. gingivalis-infected group compared to the levels in the uninfected group (P<0.01). Injection of anti-RANKL antibody (P<0.05) or OPG-Fc (P<0.01), but not L6-Fc, into rat gingival papillae after P. gingivalis infection resulted in significantly reduced periodontal bone resorption. This study suggests that P. gingivalis infection-associated periodontal bone resorption is RANKL dependent and is accompanied by increased local infiltration of RANKL-expressing T and B cells.

语种英语
WOS记录号WOS:000317582700013
项目编号DE-03420 ; DE-07327
资助机构NIH from the National Institute of Dental and Craniofacial Research
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53565
专题北京大学口腔医学院_牙周科
作者单位1.Hosp Stomatol, Beijing, Peoples R China
2.Forsyth Inst, Dept Immunol & Infect Dis, Cambridge, MA USA
3.China Med Univ, Shengjing Hosp, Dept Stomatol, Shenyang, Liaoning Provin, Peoples R China
4.Peking Univ, Dept Periodontol, Sch Stomatol, Beijing 100871, Peoples R China
5.Harbin Med Univ, Coll 4, Dept Stomatol, Harbin, Peoples R China
推荐引用方式
GB/T 7714
Han, Xiaozhe,Lin, Xiaoping,Yu, Xiaoqian,et al. Porphyromonas gingivalis Infection-Associated Periodontal Bone Resorption Is Dependent on Receptor Activator of NF-kappa B Ligand[J]. INFECTION AND IMMUNITY,2013,81(5):1502-1509.
APA Han, Xiaozhe.,Lin, Xiaoping.,Yu, Xiaoqian.,Lin, Jiang.,Kawai, Toshihisa.,...&Taubman, Martin A..(2013).Porphyromonas gingivalis Infection-Associated Periodontal Bone Resorption Is Dependent on Receptor Activator of NF-kappa B Ligand.INFECTION AND IMMUNITY,81(5),1502-1509.
MLA Han, Xiaozhe,et al."Porphyromonas gingivalis Infection-Associated Periodontal Bone Resorption Is Dependent on Receptor Activator of NF-kappa B Ligand".INFECTION AND IMMUNITY 81.5(2013):1502-1509.
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