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学科主题: 口腔医学
题名:
Porphyromonas gingivalis Infection-Associated Periodontal Bone Resorption Is Dependent on Receptor Activator of NF-kappa B Ligand
作者: Han, Xiaozhe1; Lin, Xiaoping1,2; Yu, Xiaoqian1,3,4; Lin, Jiang1,5; Kawai, Toshihisa1; LaRosa, Karen B.1; Taubman, Martin A.1
刊名: INFECTION AND IMMUNITY
发表日期: 2013-05-01
DOI: 10.1128/IAI.00043-13
卷: 81, 期:5, 页:1502-1509
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Infectious Diseases
研究领域[WOS]: Immunology ; Infectious Diseases
关键词[WOS]: T-CELLS ; OSTEOPROTEGERIN LIGAND ; IMMUNE-SYSTEM ; OSTEOCLAST DIFFERENTIATION ; LYMPHOCYTE DEVELOPMENT ; RHEUMATOID-ARTHRITIS ; POSTMENOPAUSAL WOMEN ; DISEASE ; OSTEOIMMUNOLOGY ; INDUCTION
英文摘要:

Porphyromonas gingivalis is one of the oral microorganisms associated with human chronic periodontitis. The purpose of this study is to determine the role of the receptor activator of nuclear factor-kappa B ligand (RANKL) in P. gingivalis infection-associated periodontal bone resorption. Inbred female Rowett rats were infected orally on four consecutive days (days 0 to 3) with 1 x 10(9) P. gingivalis bacteria (strain ATCC 33277). Separate groups of rats also received an injection of anti-RANKL antibody, osteoprotegerin fusion protein (OPG-Fc), or a control fusion protein (L6-Fc) into gingival papillae in addition to P. gingivalis infection. Robust serum IgG and salivary IgA antibody (P<0.01) and T cell proliferation (P<0.05) responses to P. gingivalis were detected at day 7 and peaked at day 28 in P. gingivalis-infected rats. Both the concentration of soluble RANKL (sRANKL) in rat gingival tissues (P<0.01) and periodontal bone resorption (P<0.05) were significantly elevated at day 28 in the P. gingivalis-infected group compared to levels in the uninfected group. Correspondingly, RANKL-expressing T and B cells in rat gingival tissues were significantly increased at day 28 in the P. gingivalis-infected group compared to the levels in the uninfected group (P<0.01). Injection of anti-RANKL antibody (P<0.05) or OPG-Fc (P<0.01), but not L6-Fc, into rat gingival papillae after P. gingivalis infection resulted in significantly reduced periodontal bone resorption. This study suggests that P. gingivalis infection-associated periodontal bone resorption is RANKL dependent and is accompanied by increased local infiltration of RANKL-expressing T and B cells.

语种: 英语
所属项目编号: DE-03420 ; DE-07327
项目资助者: NIH from the National Institute of Dental and Craniofacial Research
WOS记录号: WOS:000317582700013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53565
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: 1.Hosp Stomatol, Beijing, Peoples R China
2.Forsyth Inst, Dept Immunol & Infect Dis, Cambridge, MA USA
3.China Med Univ, Shengjing Hosp, Dept Stomatol, Shenyang, Liaoning Provin, Peoples R China
4.Peking Univ, Dept Periodontol, Sch Stomatol, Beijing 100871, Peoples R China
5.Harbin Med Univ, Coll 4, Dept Stomatol, Harbin, Peoples R China

Recommended Citation:
Han, Xiaozhe,Lin, Xiaoping,Yu, Xiaoqian,et al. Porphyromonas gingivalis Infection-Associated Periodontal Bone Resorption Is Dependent on Receptor Activator of NF-kappa B Ligand[J]. INFECTION AND IMMUNITY,2013,81(5):1502-1509.
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