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学科主题临床医学
Automatic neutrophil nucleus lobe counting based on graph representation of region skeleton
Qiao, Guohui; Zong, Guanghua1; Sun, Minglei; Wang, Jianzhong2
关键词Lobe Count Skeletonization Fast Marching Method Graph Theory Left And Right Shift
刊名CYTOMETRY PART A
2012-09-01
DOI10.1002/cyto.a.22083
81A期:9页:734-742
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Cell Biology
资助者Research Fund for the Doctoral Program of Higher Education of China ; National Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education of China ; National Natural Science Foundation of China
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]BLOOD-SMEAR IMAGES ; LEUKOCYTE SEGMENTATION ; CELLS ; TRANSFORMS ; SYSTEM ; FLOW
英文摘要

Abnormal neutrophil nucleus lobation (like left shift and right shift) helps to diagnose for some clinical conditions. Currently, quantification of it depends on the manual microscopic inspection of blood smears by clinicians. The quality of the manual inspection is extremely limited by the efficiency of clinicians and their medical background. This article proposed an automatic lobe counting method based on the graph representation of the nucleus region skeletons. Skeletons of the segmented nucleus regions are computed by augmented Fast Marching Method and transformed into plane graphs. Then the nucleus lobes are split based on the extracted graph properties including width distribution along the skeleton and graph structure decomposition. Experiments show that the proposed method could efficiently approaches the real lobe numbers in blood smears and reliably distinguish the stabs from the segmented neutrophils, thus it should be helpful in automatic neutrophil lobe number quantification and abnormal lobation diagnosis. (C) 2012 International Society for Advancement of Cytometry

语种英语
所属项目编号20091102120022 ; 61071158
资助者Research Fund for the Doctoral Program of Higher Education of China ; National Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education of China ; National Natural Science Foundation of China
WOS记录号WOS:000307839900004
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53574
专题北京大学第一临床医学院
作者单位1.Beihang Univ, Inst Robot, Sch Mech Engn & Automat, Beijing 100191, Peoples R China
2.Peking Univ, Dept Clin Lab, Hosp 1, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Qiao, Guohui,Zong, Guanghua,Sun, Minglei,et al. Automatic neutrophil nucleus lobe counting based on graph representation of region skeleton[J]. CYTOMETRY PART A,2012,81A(9):734-742.
APA Qiao, Guohui,Zong, Guanghua,Sun, Minglei,&Wang, Jianzhong.(2012).Automatic neutrophil nucleus lobe counting based on graph representation of region skeleton.CYTOMETRY PART A,81A(9),734-742.
MLA Qiao, Guohui,et al."Automatic neutrophil nucleus lobe counting based on graph representation of region skeleton".CYTOMETRY PART A 81A.9(2012):734-742.
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