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学科主题: 临床医学
题名:
Automatic neutrophil nucleus lobe counting based on graph representation of region skeleton
作者: Qiao, Guohui; Zong, Guanghua1; Sun, Minglei; Wang, Jianzhong2
关键词: lobe count ; skeletonization ; Fast Marching Method ; graph theory ; left and right shift
刊名: CYTOMETRY PART A
发表日期: 2012-09-01
DOI: 10.1002/cyto.a.22083
卷: 81A, 期:9, 页:734-742
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]: BLOOD-SMEAR IMAGES ; LEUKOCYTE SEGMENTATION ; CELLS ; TRANSFORMS ; SYSTEM ; FLOW
英文摘要:

Abnormal neutrophil nucleus lobation (like left shift and right shift) helps to diagnose for some clinical conditions. Currently, quantification of it depends on the manual microscopic inspection of blood smears by clinicians. The quality of the manual inspection is extremely limited by the efficiency of clinicians and their medical background. This article proposed an automatic lobe counting method based on the graph representation of the nucleus region skeletons. Skeletons of the segmented nucleus regions are computed by augmented Fast Marching Method and transformed into plane graphs. Then the nucleus lobes are split based on the extracted graph properties including width distribution along the skeleton and graph structure decomposition. Experiments show that the proposed method could efficiently approaches the real lobe numbers in blood smears and reliably distinguish the stabs from the segmented neutrophils, thus it should be helpful in automatic neutrophil lobe number quantification and abnormal lobation diagnosis. (C) 2012 International Society for Advancement of Cytometry

语种: 英语
所属项目编号: 20091102120022 ; 61071158
项目资助者: Research Fund for the Doctoral Program of Higher Education of China ; National Natural Science Foundation of China
WOS记录号: WOS:000307839900004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53574
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Beihang Univ, Inst Robot, Sch Mech Engn & Automat, Beijing 100191, Peoples R China
2.Peking Univ, Dept Clin Lab, Hosp 1, Beijing 100871, Peoples R China

Recommended Citation:
Qiao, Guohui,Zong, Guanghua,Sun, Minglei,et al. Automatic neutrophil nucleus lobe counting based on graph representation of region skeleton[J]. CYTOMETRY PART A,2012,81A(9):734-742.
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