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学科主题临床医学
Comparative effects of antihypertensive drugs on stroke outcome in China
Heeley, Emma L.1; Wei, Jade W.1; Wang, Ji-Guang2; Arima, Hisatomi1; Huang, Yining3; Wong, Lawrence K. S.1,4; Anderson, Craig S.1; ChinaQUEST Investigators
关键词Angiotensin-converting Enzyme Inhibitor Angiotensin Receptor Blocker Antihypertensive Beta-blocker Calcium Channel Blocker Diuretic Outcome Stroke
刊名INTERNATIONAL JOURNAL OF STROKE
2014-10-01
DOI10.1111/ijs.12330
suppl.A100期:SI页:113-118
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]BLOOD-PRESSURE ; RISK-FACTORS ; METAANALYSIS ; BLOCKERS ; HYPERTENSION ; MANAGEMENT ; INFARCTION ; HEMORRHAGE ; AMLODIPINE ; MASS
英文摘要

Background Antihypertensive drugs are useful in the prevention of stroke; however, much debate surrounds which class of agent provides the most benefit post-stroke.

Aims The aim of this study was to examine the impact of different classes of antihypertensive agent on stroke outcome using data from the ChinaQUEST study, a prospective, hospital-based stroke registry undertaken across 62 hospitals in China.

Methods Logistic regression analysis was used to determine the comparative associations of different antihypertensive medications when initiated in-hospital post-stroke on the following poor outcomes in stroke survivors at three-and 12 months post-stroke: (1) death and dependency, based on modified Rankin Scale scores 3-5; (2) death; and (3) dependency.

Results Of the 6416 patients with baseline data, 3986 (62%) were on at least one antihypertensive agent. After adjustment for baseline characteristics and concomitant therapies, there were no differences in outcomes between therapies at three- and 12 months, but at 12 months, calcium channel blocker use was associated with reduced risks of death/dependency (odds ratio 0.78, P = 0.001) and death (odds ratio 0.66, P < 0.001). In addition, angiotensin-converting enzyme inhibitor/angiotensin II receptor antagonist use was associated with reduced risk of death (odds ratio 0.76, P = 0.009), whereas both beta-blockers and diuretics were shown to increase the risk of death/dependency and death but had no effect on the risk of dependency.

Conclusion This study suggests that early initiation of calcium channel blockers is associated with improved outcome after stroke. Further randomized studies are warranted to confirm these findings and to delineate differential beneficial effects of antihypertensive therapy in stroke prevention.

语种英语
WOS记录号WOS:000345768700019
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53580
专题北京大学第一临床医学院_神经内科
作者单位1.Peking Univ First Hosp, Dept Neurol, Beijing, Peoples R China
2.Univ Sydney, Sydney Med Sch, George Inst Global Hlth, Sydney, NSW 2006, Australia
3.Shanghai Jiaotong Univ Sch Med, Ruijin Hosp, Ctr Epidemiol Studies & Clin Trials, Shanghai, Peoples R China
4.Chinese Univ Hong Kong, Prince Wales Hosp, Hong Kong, Hong Kong, Peoples R China
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GB/T 7714
Heeley, Emma L.,Wei, Jade W.,Wang, Ji-Guang,et al. Comparative effects of antihypertensive drugs on stroke outcome in China[J]. INTERNATIONAL JOURNAL OF STROKE,2014,suppl.A100(SI):113-118.
APA Heeley, Emma L..,Wei, Jade W..,Wang, Ji-Guang.,Arima, Hisatomi.,Huang, Yining.,...&ChinaQUEST Investigators.(2014).Comparative effects of antihypertensive drugs on stroke outcome in China.INTERNATIONAL JOURNAL OF STROKE,suppl.A100(SI),113-118.
MLA Heeley, Emma L.,et al."Comparative effects of antihypertensive drugs on stroke outcome in China".INTERNATIONAL JOURNAL OF STROKE suppl.A100.SI(2014):113-118.
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