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学科主题: 临床医学
题名:
A study of TNF-alpha-238 and -308 polymorphisms with different outcomes of persistent hepatitis B virus infection in China
作者: Wang, Binbin1,2,3; Wang, Jing2,3; Zheng, Yingying1; Zhou, Sirui2,3; Zheng, Jinxin1; Wang, Fang1; Ma, Xu2,3,4; Zeng, Zheng1; HBV Study Consortium
关键词: Tumour necrosis factor alpha ; rs1800629 ; chronic hepatitis B ; liver cirrhosis ; LC ; hepatocellular carcinoma ; HCC
刊名: PATHOLOGY
发表日期: 2010-12-01
DOI: 10.3109/00313025.2010.523696
卷: 42, 期:7, 页:674-680
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: TUMOR-NECROSIS-FACTOR ; ALPHA PROMOTER POLYMORPHISMS ; NF-KAPPA-B ; HEPATOCELLULAR-CARCINOMA ; GENE POLYMORPHISMS ; ASSOCIATION ; ACTIVATION ; CLEARANCE ; DISEASE ; EPIDEMIOLOGY
英文摘要:

Background: Two common functional polymorphisms in the promoter region of TNF-alpha located at nucleotides -238 (rs361525) and -308 (rs1800629) have been reported to regulate the expression of tumour necrosis factor alpha (TNF-alpha) and to be associated with hepatitis B virus (HBV) infection related diseases. However, their frequencies and associations with outcomes of HBV infection are not clear.

Methods: We performed a genetic analysis of 956 Chinese Han subjects, who were divided into a HBV clearance group, an asymptomatic persistent infection group, a chronic hepatitis B group, two stages of liver cirrhosis (LC) groups, and three stages of hepatocellular carcinoma (HCC) groups to examine the relationship among HBV infection related diseases and these two single nucleotide polymorphisms (SNPs).

Results: The phenotype of polymorphism -238 in all study samples displayed no significant differences among the eight subgroups. The distribution of -308 phenotypes among the eight groups differed significantly. For females, compared with persistent infection, LC patients had a significantly higher A allele frequency, and the association with cirrhosis progression was significant. For males, there were statistically significant differences in allele distributions between the persistent infection group and the HCC group. The AG haplotype (-A308, -G238) was associated significantly with HCC development.

Conclusions: The results of the present study indicate an association between rs1800629 and HBV related disease progression in the Chinese Han population. The association was different between genders, with the rs1800629 A allele being a risk factor for female carriers to develop LC, and the allele being a risk factor for male carriers to develop HCC, especially in subjects with an alcohol abuse or cigarette smoking history.

语种: 英语
所属项目编号: 2008BAH24B05 ; 2006DKA21300 ; 30671855 ; N01-CO-12400
项目资助者: National Science and Technology Pillar Program of China ; National Infrastructure Program of Chinese Genetic Resources ; National Nature Science Foundation of China ; National Cancer Institute, National Institute of Health, USA
WOS记录号: WOS:000284317000012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53588
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: 1.Peking Univ, Dept Infect Dis, Hosp 1, Beijing 100034, Peoples R China
2.Peking Union Med Coll, Grad Sch, Beijing 100021, Peoples R China
3.Natl Res Inst Family Planning, Beijing, Peoples R China
4.World Hlth Org Collaborating Ctr Res Human Reprod, Beijing, Peoples R China

Recommended Citation:
Wang, Binbin,Wang, Jing,Zheng, Yingying,et al. A study of TNF-alpha-238 and -308 polymorphisms with different outcomes of persistent hepatitis B virus infection in China[J]. PATHOLOGY,2010,42(7):674-680.
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