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学科主题: 临床医学
题名:
Decreased prothrombin time after intravitreal bevacizumab in the early period in patients with proliferative diabetic retinopathy
作者: Qian, Jing; Jiang, Yan-Rong
关键词: diabetes ; intravitreal bevacizumab ; proliferative diabetic retinopathy ; prothrombin time
刊名: ACTA OPHTHALMOLOGICA
发表日期: 2011-06-01
DOI: 10.1111/j.1755-3768.2011.02151.x
卷: 89, 期:4, 页:E332-E335
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: ENDOTHELIAL GROWTH-FACTOR ; CARDIOVASCULAR-DISEASE ; BEVACKUMAB AVASTIN ; ANTI-VEGF ; PHARMACOKINETICS ; ANGIOGENESIS ; CHEMOTHERAPY ; INJECTION ; THERAPY ; RISK
英文摘要:

Purpose: To evaluate the effect of intravitreal bevacizumab (Avastin; Genentech, Inc., San Francisco, CA, USA) (IVB) injection on prothrombin time (PT) in patients with proliferative diabetic retinopathy (PDR) and nondiabetic patients.

Methods: Eighty-nine patients received primary IVB (1.25 mg) in one eye were investigated. The patients were divided into three groups: 34 PDR (diabetic group), 26 nondiabetic (nondiabetic group) patients received IVB and 29 PDR patients without IVB (control group). The levels of PT were detected before and after IVB in study groups and at corresponding time-points in the control group. Paired samples t-test was conducted to compare the statistical differences of PT in each group.

Results: Significant difference (p < 0.001) of the levels of PT before and after IVB was observed in diabetic group in the early period, and the PT changes (11.0 +/- 0.56 before and 10.6 +/- 0.45 after IVB) were in fact within the normal range. There were no significant differences in other groups and other time-points (all p > 0.05).

Conclusions: Intravitreal bevacizumab may lead to a decrease in the levels of PT in the early period after IVB in PDR patients, suggesting a temporarily potential effect of IVB on the extrinsic clotting pathway of blood coagulation cascade in diabetic patients.

语种: 英语
WOS记录号: WOS:000291057200007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53591
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100044, Peoples R China

Recommended Citation:
Qian, Jing,Jiang, Yan-Rong. Decreased prothrombin time after intravitreal bevacizumab in the early period in patients with proliferative diabetic retinopathy[J]. ACTA OPHTHALMOLOGICA,2011,89(4):E332-E335.
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