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Decreased prothrombin time after intravitreal bevacizumab in the early period in patients with proliferative diabetic retinopathy
Qian, Jing; Jiang, Yan-Rong
关键词Diabetes Intravitreal Bevacizumab Proliferative Diabetic Retinopathy Prothrombin Time
刊名ACTA OPHTHALMOLOGICA
2011-06-01
DOI10.1111/j.1755-3768.2011.02151.x
89期:4页:E332-E335
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]ENDOTHELIAL GROWTH-FACTOR ; CARDIOVASCULAR-DISEASE ; BEVACKUMAB AVASTIN ; ANTI-VEGF ; PHARMACOKINETICS ; ANGIOGENESIS ; CHEMOTHERAPY ; INJECTION ; THERAPY ; RISK
英文摘要

Purpose: To evaluate the effect of intravitreal bevacizumab (Avastin; Genentech, Inc., San Francisco, CA, USA) (IVB) injection on prothrombin time (PT) in patients with proliferative diabetic retinopathy (PDR) and nondiabetic patients.

Methods: Eighty-nine patients received primary IVB (1.25 mg) in one eye were investigated. The patients were divided into three groups: 34 PDR (diabetic group), 26 nondiabetic (nondiabetic group) patients received IVB and 29 PDR patients without IVB (control group). The levels of PT were detected before and after IVB in study groups and at corresponding time-points in the control group. Paired samples t-test was conducted to compare the statistical differences of PT in each group.

Results: Significant difference (p < 0.001) of the levels of PT before and after IVB was observed in diabetic group in the early period, and the PT changes (11.0 +/- 0.56 before and 10.6 +/- 0.45 after IVB) were in fact within the normal range. There were no significant differences in other groups and other time-points (all p > 0.05).

Conclusions: Intravitreal bevacizumab may lead to a decrease in the levels of PT in the early period after IVB in PDR patients, suggesting a temporarily potential effect of IVB on the extrinsic clotting pathway of blood coagulation cascade in diabetic patients.

语种英语
WOS记录号WOS:000291057200007
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53591
专题北京大学第二临床医学院_眼科
北京大学口腔医学院_外科
作者单位Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100044, Peoples R China
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Qian, Jing,Jiang, Yan-Rong. Decreased prothrombin time after intravitreal bevacizumab in the early period in patients with proliferative diabetic retinopathy[J]. ACTA OPHTHALMOLOGICA,2011,89(4):E332-E335.
APA Qian, Jing,&Jiang, Yan-Rong.(2011).Decreased prothrombin time after intravitreal bevacizumab in the early period in patients with proliferative diabetic retinopathy.ACTA OPHTHALMOLOGICA,89(4),E332-E335.
MLA Qian, Jing,et al."Decreased prothrombin time after intravitreal bevacizumab in the early period in patients with proliferative diabetic retinopathy".ACTA OPHTHALMOLOGICA 89.4(2011):E332-E335.
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