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学科主题临床医学
Effects of Helicobacter pylori Treatment on Gastric Cancer Incidence and Mortality in Subgroups
Li, Wen-Qing1,2; Ma, Jun-Ling2; Zhang, Lian2; Brown, Linda M.3; Li, Ji-You2; Shen, Lin2; Pan, Kai-Feng2; Liu, Wei-Dong4; Hu, Yuanreng; Han, Zhong-Xiang4; Crystal-Mansour, Susan5; Pee, David6; Blot, William J.7,8; Fraumeni, Joseph F., Jr.1; You, Wei-Cheng2; Gail, Mitchell H.1
刊名JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
2014-07-01
DOI10.1093/jnci/dju116
106期:7
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]RANDOMIZED CONTROLLED-TRIAL ; HIGH-RISK ; FACTORIAL TRIAL ; LESIONS ; ERADICATION ; POPULATION ; REDUCE ; CHINA
英文摘要

Among 2258 Helicobacter pylori-seropositive subjects randomly assigned to receive one-time H. pylori treatment with amoxicillin-omeprazole or its placebo, we evaluated the 15-year effect of treatment on gastric cancer incidence and mortality in subgroups defined by age, baseline gastric histopathology, and post-treatment infection status. We used conditional logistic and Cox regressions for covariable adjustments in incidence and mortality analyses, respectively. Treatment was associated with a statistically significant decrease in gastric cancer incidence (odds ratio = 0.36; 95% confidence interval [CI] = 0.17 to 0.79) and mortality (hazard ratio = 0.26; 95% CI = 0.09 to 0.79) at ages 55 years and older and a statistically significant decrease in incidence among those with intestinal metaplasia or dysplasia at baseline (odds ratio = 0.56; 95% CI = 0.34 to 0.91). Treatment benefits for incidence and mortality among those with and without post-treatment infection were similar. Thus H. pylori treatment can benefit older members and those with advanced baseline histopathology, and benefits are present even with post-treatment infection, suggesting treatment can benefit an entire population, not just the young or those with mild histopathology.

语种英语
WOS记录号WOS:000341637400004
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53592
专题北京大学临床肿瘤学院_流行病学研究室
作者单位1.RTI Int, Rockville, MD USA
2.Linqu Cty Publ Hlth Bur, Linqu, Shandong, Peoples R China
3.WESTAT Corp, Rockville, MD 20850 USA
4.Informat Management Serv Inc, Rockville, MD USA
5.Int Epidemiol Inst, Rockville, MD USA
6.Vanderbilt Univ, Dept Med Epidemiol, Nashville, TN 37235 USA
7.NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
8.Peking Univ, Canc Hosp & Inst, Dept Canc Epidemiol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Li, Wen-Qing,Ma, Jun-Ling,Zhang, Lian,et al. Effects of Helicobacter pylori Treatment on Gastric Cancer Incidence and Mortality in Subgroups[J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE,2014,106(7).
APA Li, Wen-Qing.,Ma, Jun-Ling.,Zhang, Lian.,Brown, Linda M..,Li, Ji-You.,...&Gail, Mitchell H..(2014).Effects of Helicobacter pylori Treatment on Gastric Cancer Incidence and Mortality in Subgroups.JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE,106(7).
MLA Li, Wen-Qing,et al."Effects of Helicobacter pylori Treatment on Gastric Cancer Incidence and Mortality in Subgroups".JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 106.7(2014).
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