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IR@PKUHSC  > 北京大学临床肿瘤学院  > 流行病学研究室  > 期刊论文
学科主题: 临床医学
题名:
Effects of Helicobacter pylori Treatment on Gastric Cancer Incidence and Mortality in Subgroups
作者: Li, Wen-Qing1,2; Ma, Jun-Ling2; Zhang, Lian2; Brown, Linda M.3; Li, Ji-You2; Shen, Lin2; Pan, Kai-Feng2; Liu, Wei-Dong4; Hu, Yuanreng; Han, Zhong-Xiang4; Crystal-Mansour, Susan5; Pee, David6; Blot, William J.7,8; Fraumeni, Joseph F., Jr.1; You, Wei-Cheng2; Gail, Mitchell H.1
刊名: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
发表日期: 2014-07-01
DOI: 10.1093/jnci/dju116
卷: 106, 期:7
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: RANDOMIZED CONTROLLED-TRIAL ; HIGH-RISK ; FACTORIAL TRIAL ; LESIONS ; ERADICATION ; POPULATION ; REDUCE ; CHINA
英文摘要:

Among 2258 Helicobacter pylori-seropositive subjects randomly assigned to receive one-time H. pylori treatment with amoxicillin-omeprazole or its placebo, we evaluated the 15-year effect of treatment on gastric cancer incidence and mortality in subgroups defined by age, baseline gastric histopathology, and post-treatment infection status. We used conditional logistic and Cox regressions for covariable adjustments in incidence and mortality analyses, respectively. Treatment was associated with a statistically significant decrease in gastric cancer incidence (odds ratio = 0.36; 95% confidence interval [CI] = 0.17 to 0.79) and mortality (hazard ratio = 0.26; 95% CI = 0.09 to 0.79) at ages 55 years and older and a statistically significant decrease in incidence among those with intestinal metaplasia or dysplasia at baseline (odds ratio = 0.56; 95% CI = 0.34 to 0.91). Treatment benefits for incidence and mortality among those with and without post-treatment infection were similar. Thus H. pylori treatment can benefit older members and those with advanced baseline histopathology, and benefits are present even with post-treatment infection, suggesting treatment can benefit an entire population, not just the young or those with mild histopathology.

语种: 英语
所属项目编号: NO2-CP-71103 ; NO2-CP-21169 ; 2004CB518702 ; 2010CB529303
项目资助者: National Institutes of Health, National Cancer Institute ; National Cancer Institute ; National Basic Research Program of China (973 program)
WOS记录号: WOS:000341637400004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53592
Appears in Collections:北京大学临床肿瘤学院_流行病学研究室_期刊论文

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作者单位: 1.RTI Int, Rockville, MD USA
2.Linqu Cty Publ Hlth Bur, Linqu, Shandong, Peoples R China
3.WESTAT Corp, Rockville, MD 20850 USA
4.Informat Management Serv Inc, Rockville, MD USA
5.Int Epidemiol Inst, Rockville, MD USA
6.Vanderbilt Univ, Dept Med Epidemiol, Nashville, TN 37235 USA
7.NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
8.Peking Univ, Canc Hosp & Inst, Dept Canc Epidemiol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China

Recommended Citation:
Li, Wen-Qing,Ma, Jun-Ling,Zhang, Lian,et al. Effects of Helicobacter pylori Treatment on Gastric Cancer Incidence and Mortality in Subgroups[J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE,2014,106(7).
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