IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Early sensory protection in reverse end-to-side neurorrhaphy to improve the functional recovery of chronically denervated muscle in rat: a pilot study
Li, Qingtian; Zhang, Peixun; Yin, Xiaofeng; Han, Na; Kou, Yuhui; Jiang, Baoguo
关键词Muscle Denervation Muscle Reinnervation Peripheral Nerve Nerve Regeneration End-to-side Neurorrhaphy Babysitter Technique
刊名JOURNAL OF NEUROSURGERY
2014-08-01
DOI10.3171/2014.4.JNS131723
121期:2页:415-422
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Surgery
研究领域[WOS]Neurosciences & Neurology ; Surgery
关键词[WOS]SCHWANN-CELL DENERVATION ; PERIPHERAL-NERVE REGENERATION ; NEUROTROPHIC FACTOR ; SKELETAL-MUSCLE ; EXPRESSION ; TERM ; MOTOR ; NGF ; REINNERVATION ; PRESERVATION
英文摘要

Object. Early innervation by sensory nerves has been proposed to prevent atrophy of chronically denervated muscle, but conventional end-to-end (ETE) neurorrhaphy has been demonstrated to have adverse effects on muscle contractile function. The aim of the present study was to investigate the potential for modified sensory nerve protection in reverse end-to-side (ETS) neurorrhaphy as a way of improving the functional recovery of denervated muscle.

Methods. Four groups of rats underwent surgical denervation of the tibial nerve projecting to the right hindlimbs (Group 1, unprotected controls; Group 2, positive control [immediate repair without delayed denervation]; Group 3, ETS protected; and Group 4, ETE protected). The proximal and distal stumps of the tibial nerve were ligated in all animals except for those in the immediate-repair group. Other animals underwent denervation without sural nerve protection, or with ETE or ETS neurorrhaphy. The ETE- and ETS-protected and unprotected groups underwent an additional surgery in which the trimmed proximal and distal tibial nerve stumps were sutured together. After 3 months of recovery, the tibial function index was determined, and electrophysiological, histological, and morphometric parameters were assessed.

Results. Significant muscle atrophy was observed in the unprotected group, while a well-preserved ultrastructure was observed for the gastrocnemius muscle in the ETE- and ETS-protected groups Enhanced recovery in the ETS-protected group was indicated by the tibial function index, motor nerve conduction velocity, muscle contractile force tests, and the histological results. In contrast, early sensory nerve protection in ETE neurorrhaphy impaired the recovery of the regenerated axons and diminished the contractile force of the denervated muscle.

Conclusions. Early sensory protection in reverse ETS neurorrhaphy is an effective method for improving the functional recovery of chronically denervated muscle following peripheral nerve injury in rats.

语种英语
WOS记录号WOS:000339473000026
项目编号2014CB542200 ; 31171150 ; 31271284 ; 81171146 ; 30971526 ; 30801169 ; 31100860 ; 2008-A-10 ; BMU20110270
资助机构Chinese National Ministry of Science and Technology 973 Project Planning ; National Nature Science Foundation of China ; Beijing Science &amp ; Technology New Star Classification ; Program for New Century Excellent Talents in University
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53597
专题北京大学第二临床医学院
北京大学第二临床医学院_创伤骨科
北京大学第二临床医学院_党委院长办公室
作者单位Peking Univ, Peoples Hosp, Dept Trauma & Orthopaed, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Li, Qingtian,Zhang, Peixun,Yin, Xiaofeng,et al. Early sensory protection in reverse end-to-side neurorrhaphy to improve the functional recovery of chronically denervated muscle in rat: a pilot study[J]. JOURNAL OF NEUROSURGERY,2014,121(2):415-422.
APA Li, Qingtian,Zhang, Peixun,Yin, Xiaofeng,Han, Na,Kou, Yuhui,&Jiang, Baoguo.(2014).Early sensory protection in reverse end-to-side neurorrhaphy to improve the functional recovery of chronically denervated muscle in rat: a pilot study.JOURNAL OF NEUROSURGERY,121(2),415-422.
MLA Li, Qingtian,et al."Early sensory protection in reverse end-to-side neurorrhaphy to improve the functional recovery of chronically denervated muscle in rat: a pilot study".JOURNAL OF NEUROSURGERY 121.2(2014):415-422.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Qingtian]的文章
[Zhang, Peixun]的文章
[Yin, Xiaofeng]的文章
百度学术
百度学术中相似的文章
[Li, Qingtian]的文章
[Zhang, Peixun]的文章
[Yin, Xiaofeng]的文章
必应学术
必应学术中相似的文章
[Li, Qingtian]的文章
[Zhang, Peixun]的文章
[Yin, Xiaofeng]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。