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学科主题: 临床医学
题名:
Early sensory protection in reverse end-to-side neurorrhaphy to improve the functional recovery of chronically denervated muscle in rat: a pilot study
作者: Li, Qingtian; Zhang, Peixun; Yin, Xiaofeng; Han, Na; Kou, Yuhui; Jiang, Baoguo
关键词: muscle denervation ; muscle reinnervation ; peripheral nerve ; nerve regeneration ; end-to-side neurorrhaphy ; babysitter technique
刊名: JOURNAL OF NEUROSURGERY
发表日期: 2014-08-01
DOI: 10.3171/2014.4.JNS131723
卷: 121, 期:2, 页:415-422
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Surgery
研究领域[WOS]: Neurosciences & Neurology ; Surgery
关键词[WOS]: SCHWANN-CELL DENERVATION ; PERIPHERAL-NERVE REGENERATION ; NEUROTROPHIC FACTOR ; SKELETAL-MUSCLE ; EXPRESSION ; TERM ; MOTOR ; NGF ; REINNERVATION ; PRESERVATION
英文摘要:

Object. Early innervation by sensory nerves has been proposed to prevent atrophy of chronically denervated muscle, but conventional end-to-end (ETE) neurorrhaphy has been demonstrated to have adverse effects on muscle contractile function. The aim of the present study was to investigate the potential for modified sensory nerve protection in reverse end-to-side (ETS) neurorrhaphy as a way of improving the functional recovery of denervated muscle.

Methods. Four groups of rats underwent surgical denervation of the tibial nerve projecting to the right hindlimbs (Group 1, unprotected controls; Group 2, positive control [immediate repair without delayed denervation]; Group 3, ETS protected; and Group 4, ETE protected). The proximal and distal stumps of the tibial nerve were ligated in all animals except for those in the immediate-repair group. Other animals underwent denervation without sural nerve protection, or with ETE or ETS neurorrhaphy. The ETE- and ETS-protected and unprotected groups underwent an additional surgery in which the trimmed proximal and distal tibial nerve stumps were sutured together. After 3 months of recovery, the tibial function index was determined, and electrophysiological, histological, and morphometric parameters were assessed.

Results. Significant muscle atrophy was observed in the unprotected group, while a well-preserved ultrastructure was observed for the gastrocnemius muscle in the ETE- and ETS-protected groups Enhanced recovery in the ETS-protected group was indicated by the tibial function index, motor nerve conduction velocity, muscle contractile force tests, and the histological results. In contrast, early sensory nerve protection in ETE neurorrhaphy impaired the recovery of the regenerated axons and diminished the contractile force of the denervated muscle.

Conclusions. Early sensory protection in reverse ETS neurorrhaphy is an effective method for improving the functional recovery of chronically denervated muscle following peripheral nerve injury in rats.

语种: 英语
所属项目编号: 2014CB542200 ; 31171150 ; 31271284 ; 81171146 ; 30971526 ; 30801169 ; 31100860 ; 2008-A-10 ; BMU20110270
项目资助者: Chinese National Ministry of Science and Technology 973 Project Planning ; National Nature Science Foundation of China ; Beijing Science &amp ; Technology New Star Classification ; Program for New Century Excellent Talents in University
WOS记录号: WOS:000339473000026
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53597
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Trauma & Orthopaed, Beijing 100044, Peoples R China

Recommended Citation:
Li, Qingtian,Zhang, Peixun,Yin, Xiaofeng,et al. Early sensory protection in reverse end-to-side neurorrhaphy to improve the functional recovery of chronically denervated muscle in rat: a pilot study[J]. JOURNAL OF NEUROSURGERY,2014,121(2):415-422.
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