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学科主题: 临床医学
题名:
Prevalence of dyslipidaemia in patients treated with lipid-lowering agents in China: Results of the DYSlipidemia International Study (DYSIS)
作者: Zhao, Shuiping1; Wang, Yongjun2; Mu, Yiming3; Yu, Bilian1; Ye, Ping4; Yan, Xiaowei5,6; Li, Zhanquan7; Wei, Yidong8; Ambegaonakr, Baishaili M.9; Hu, Dayi10; DYSIS-China Study Investigators
关键词: Cardiovascular diseases ; Dyslipidaemia ; Statin ; Lipid-lowering agents ; LDL cholesterol ; Non-HDL cholesterol
刊名: ATHEROSCLEROSIS
发表日期: 2014-08-01
DOI: 10.1016/j.atherosclerosis.2014.05.916
卷: 235, 期:2, 页:463-469
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: CORONARY-HEART-DISEASE ; HIGH-DENSITY LIPOPROTEIN ; CLINICAL-PRACTICE ; CHOLESTEROL GOAL ; DIABETES-MELLITUS ; HIGH-RISK ; STATIN ; MANAGEMENT ; ABNORMALITIES ; CANADA
英文摘要:

Background: Despite clear guideline recommendations, there is a paucity of data regarding the prevalence and type of persistent lipid profile abnormalities in patients on stable lipid-lowering therapy in China.

Methods: This cross-sectional trial included 25,697 patients treated with lipid-lowering agents from 122 centres between April 2012 and October 2012; all underwent clinical examination and had their latest fasting lipid profiles while on lipid-lowering therapy recorded. Logistic regression was performed to assess predictors for lipid abnormalities classified according to current Chinese guidelines.

Findings: Overall, 29.1% of patients had no lipid abnormalities, and 38.5% of patients did not achieve the therapeutic goal for low-density lipoprotein cholesterol (LDL-C), either as a single lipid anomaly or associated with low high-density lipoprotein cholesterol (HDL-C), elevated triglycerides, or both. Subjects with low risk were more likely than those with very high and high risk to be at target LDL-C levels. Furthermore, 10.4% of very high-risk patients and 11.1% of high-risk patients who attained the LDL-C goal failed to attain non-HDL-C goals. Diabetes was shown to be a strong predictor of failure in attaining non-HDL-C and both goals (OR 3.03; 3.22, 95% CI 2.58-3.55; 2.73-3.79, respectively).

Conclusion: Although great improvements have been made over the past decade, the large majority of very high-risk and high-risk patients treated with lipid-lowing agents still had one or more manifestations of dyslipidaemia. Further clinical evidence is needed to clarify whether adding other lipid-lowering agents to a statin will be associated with additional cardiovascular risk reduction. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 39298
项目资助者: Merck &amp ; Co., Ltd (IISP)
WOS记录号: WOS:000342411000932
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53602
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Merck & Co Inc, Whitehouse Stn, NJ USA
2.Cent S Univ, Xiangya Hosp 2, Dept Cardiol, Changsha 410011, Hunan, Peoples R China
3.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China
4.Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing 100853, Peoples R China
5.Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Cardiol, Beijing 100853, Peoples R China
6.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Cardiol, Beijing 100730, Peoples R China
7.Peking Union Med Coll, Beijing 100730, Peoples R China
8.Peoples Hosp Liaoning Prov, Dept Cardiol, Shenyang 110016, Peoples R China
9.Tonidi Univ, Peoples Hosp 10, Dept Cardiol, Shanghai 200072, Peoples R China
10.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China

Recommended Citation:
Zhao, Shuiping,Wang, Yongjun,Mu, Yiming,et al. Prevalence of dyslipidaemia in patients treated with lipid-lowering agents in China: Results of the DYSlipidemia International Study (DYSIS)[J]. ATHEROSCLEROSIS,2014,235(2):463-469.
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