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学科主题: 临床医学
题名:
Investigation on Fourier Transform Infrared Spectrum of Freshly Resected Cholangiocarcinoma Tissue
作者: Yin Gang1; Xu Zhi1; Xu Yi-zhuang2; Sun Qi-gang1; Liu Ya-qi1; Zhang Yuan-fu2; Wu Jin-guang2; Zhou Xiao-si1; Ling Xiao-feng1
关键词: FTIR ; Cholangiocarcinoma ; Freshly resected tissue
刊名: SPECTROSCOPY AND SPECTRAL ANALYSIS
发表日期: 2009-12-01
DOI: 10.3964/j.issn.1000-0593(2009)12-3241-05
卷: 29, 期:12, 页:3241-3245
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Spectroscopy
研究领域[WOS]: Spectroscopy
关键词[WOS]: BILE-DUCT CANCER ; SPECTROSCOPY ; CARCINOMA
英文摘要:

To explore the feasibility of quick intraoperative in situ and noninvasive diagnosis of cholangiocarcinoma by Fourier transform infrared (FTIR) spectroscopy, 26 samples of freshly resected cholangiocarcinoma tissues and 43 samples of benign bile duct tissue were collected during surgery. And all fresh samples were measured by FTIR spectroscopy via probe of attenuated total reflection (ATR) without pretreatment immediately after resection. For each spectrum, 12 bands were identified and assigned between 3 800 and 1 000 cm(-1). The peak position was found. and the intensity and area of the bands were measured; The ratios of the intensity and area were calculated. Standard statistic analysis was performed. The results illustrated that the FTIR spectra of malignant tissue were significantly different from those of benign tissue: 1. The bands related to lipid: The peak of 2 925 cm-1 shifted to lower wave number significantly (P=0.033); 2. The bands related to nucleic: acid and lipids: the ratios of I(1) (083)/I(1) (460) (P=0.005) S(1) (083)/S(1) (460) ( P=0.001) and S(1) (240)/S(1) (460) (P=0.025) raised significantly, indicating that the relative quantity of nucleic acid to lipids had evidently increased in malignancy. 3. The hands related to protein: The ratios of I(1) (550)/I(1) (083) (P=0.000) and S(1) (550)/S(1) (083) (P=0.000) reduced significantly implying that the relative quantity of protein to nucleic acid in malignancy decreased significantly and the secondary structure of protein changed probably. Our primary result illustrated that the FTIR spectroscopy technique maybe a promising method for in situ and quick intraoperative diagnosis of cholangiocarcinoma and has great value for clinical application.

语种: 中文
WOS记录号: WOS:000272565300018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53605
Appears in Collections:北京大学第三临床医学院_普通外科_期刊论文

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作者单位: 1.Peking Univ, Dept Gen Surg, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China

Recommended Citation:
Yin Gang,Xu Zhi,Xu Yi-zhuang,et al. Investigation on Fourier Transform Infrared Spectrum of Freshly Resected Cholangiocarcinoma Tissue[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS,2009,29(12):3241-3245.
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