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学科主题: 药学
题名:
HPLC method for comparative in rat after oral administration study on tissue distribution of salvianolic acid B and phenolic acids from Salvia miltiorrhiza
作者: Xu, Man; Fu, Gang; Qiao, Xue; Wu, Wan-Ying; Guo, Hui; Liu, Ai-Hua; Sun, Jiang-Hao; Guo, De-An
关键词: Salvia miltiorrhiza ; total phenolic acids ; salvianolic acid B ; tissue distribution ; metabolism
刊名: BIOMEDICAL CHROMATOGRAPHY
发表日期: 2007-10-01
DOI: 10.1002/bmc.852
卷: 21, 期:10, 页:1052-1063
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: MAGNESIUM LITHOSPERMATE-B ; CHROMATOGRAPHY/TANDEM MASS-SPECTROMETRY ; BEAGLE DOG SERUM ; LIQUID-CHROMATOGRAPHY ; ROSMARINIC ACID ; DANSHEN ; CELLS ; RADIX ; COMPONENT ; EXTRACT
英文摘要:

A sensitive and selective high-performance liquid chromatography method was developed and validated to determine the prototype of salvianolic acid B and the metabolites of phenolic acids (protocatechuic acid, vanillic acid and ferulic acid) in rat tissues after oral administration of total phenolic acids and salvianolic acid B extracted from the roots of Salvia miltiorrhiza, respectively. The tissue samples were treated with a simple liquid-liquid extraction prior to HPLC. Analysis of the extract was performed on a reverse-phase C, column with a mobile phase consisting of acetonitrile and 0.05% trifluoracetic acid. The calibration curves for the four phenolic acids were linear in the given concentration ranges. The intra-day and inter-day relative standard deviations in the measurement of quality control samples were less than 10% and the accuracies were in the range of 88-115%. The average recoveries of all the tissues ranged from 78.0 to 111.8%. This method was successfully applied to evaluate the distribution of the four phenolic acids in rat tissues after oral administration of total phenolic acids of Salvia miltiorrhiza or salvianolic acid B and the possible metabolic pathway was illustrated. Copyright (c) 2007 John Wiley & Sons, Ltd.

语种: 英语
WOS记录号: WOS:000249846400008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53606
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Xu, Man,Fu, Gang,Qiao, Xue,et al. HPLC method for comparative in rat after oral administration study on tissue distribution of salvianolic acid B and phenolic acids from Salvia miltiorrhiza[J]. BIOMEDICAL CHROMATOGRAPHY,2007,21(10):1052-1063.
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