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HPLC method for comparative in rat after oral administration study on tissue distribution of salvianolic acid B and phenolic acids from Salvia miltiorrhiza
Xu, Man; Fu, Gang; Qiao, Xue; Wu, Wan-Ying; Guo, Hui; Liu, Ai-Hua; Sun, Jiang-Hao; Guo, De-An
关键词Salvia Miltiorrhiza Total Phenolic Acids Salvianolic Acid b Tissue Distribution Metabolism
刊名BIOMEDICAL CHROMATOGRAPHY
2007-10-01
DOI10.1002/bmc.852
21期:10页:1052-1063
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]MAGNESIUM LITHOSPERMATE-B ; CHROMATOGRAPHY/TANDEM MASS-SPECTROMETRY ; BEAGLE DOG SERUM ; LIQUID-CHROMATOGRAPHY ; ROSMARINIC ACID ; DANSHEN ; CELLS ; RADIX ; COMPONENT ; EXTRACT
英文摘要

A sensitive and selective high-performance liquid chromatography method was developed and validated to determine the prototype of salvianolic acid B and the metabolites of phenolic acids (protocatechuic acid, vanillic acid and ferulic acid) in rat tissues after oral administration of total phenolic acids and salvianolic acid B extracted from the roots of Salvia miltiorrhiza, respectively. The tissue samples were treated with a simple liquid-liquid extraction prior to HPLC. Analysis of the extract was performed on a reverse-phase C, column with a mobile phase consisting of acetonitrile and 0.05% trifluoracetic acid. The calibration curves for the four phenolic acids were linear in the given concentration ranges. The intra-day and inter-day relative standard deviations in the measurement of quality control samples were less than 10% and the accuracies were in the range of 88-115%. The average recoveries of all the tissues ranged from 78.0 to 111.8%. This method was successfully applied to evaluate the distribution of the four phenolic acids in rat tissues after oral administration of total phenolic acids of Salvia miltiorrhiza or salvianolic acid B and the possible metabolic pathway was illustrated. Copyright (c) 2007 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000249846400008
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53606
专题北京大学药学院
作者单位Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Xu, Man,Fu, Gang,Qiao, Xue,et al. HPLC method for comparative in rat after oral administration study on tissue distribution of salvianolic acid B and phenolic acids from Salvia miltiorrhiza[J]. BIOMEDICAL CHROMATOGRAPHY,2007,21(10):1052-1063.
APA Xu, Man.,Fu, Gang.,Qiao, Xue.,Wu, Wan-Ying.,Guo, Hui.,...&Guo, De-An.(2007).HPLC method for comparative in rat after oral administration study on tissue distribution of salvianolic acid B and phenolic acids from Salvia miltiorrhiza.BIOMEDICAL CHROMATOGRAPHY,21(10),1052-1063.
MLA Xu, Man,et al."HPLC method for comparative in rat after oral administration study on tissue distribution of salvianolic acid B and phenolic acids from Salvia miltiorrhiza".BIOMEDICAL CHROMATOGRAPHY 21.10(2007):1052-1063.
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