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学科主题基础医学
Homeostatic Properties and Phenotypic Maturation of Murine CD4(+) Pre-Thymic Emigrants in the Thymus
Dong, Jie1; Chen, Yu1; Xu, Xi1; Jin, Rong1; Teng, Fei1; Yan, Fan1; Tang, Hui1; Li, Pingping1; Sun, Xiuyuan1; Li, Yan1; Wu, Hounan2; Zhang, Yu1; Ge, Qing1
刊名PLOS ONE
2013-02-11
DOI10.1371/journal.pone.0056378
8期:2
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者Natural Basic Research Program of China ; National Natural Sciences Foundation of China ; Program for New Century Excellent Talents in University ; Research Fund for the Doctoral Program of Higher Education ; Natural Basic Research Program of China ; National Natural Sciences Foundation of China ; Program for New Century Excellent Talents in University ; Research Fund for the Doctoral Program of Higher Education
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]T-CELLS ; DENDRITIC CELLS ; THYMOCYTE DEVELOPMENT ; MEDULLARY THYMOCYTES ; LYMPHOKINE SECRETION ; CENTRAL TOLERANCE ; AGED MICE ; IN-VIVO ; SELECTION ; REPERTOIRE
英文摘要

After a tightly regulated developmental program in the thymus, "mature" single positive (SP) thymocytes leave the thymus and enter the periphery. These newly arrived recent thymic emigrants (RTEs) are phenotypically and functionally immature, and will complete a dynamic maturation in the peripheral lymphoid organs before being licensed to be resident naive T cells. To study the early events occurring in the RTE maturation process, we identified the phenotype of CD4(+) pre-RTEs, a population of CD4(+) SP thymocytes that have acquired the thymus egress capability. Compared to peripheral naive T cells, CD4(+) pre-RTEs displayed superior survival capability in lymphoreplete mice and faster proliferation under lymphopenic condition. The differences in Bcl2/Bim expression and/or heightened IL-7 signaling pathway may account for the pre-RTEs′ better responsiveness to homeostatic signals. Qa2, the expression of which indicates the phenotypic maturation of SPs and RTEs, was found to be upregulated in CD4(+) pre-RTEs in thymic perivascular space. Migratory dendritic cells that surround this region contribute to Qa2 expression in pre-RTEs. The dendritic cell-driven Qa2 induction of CD4(+) pre-RTEs is independent of MHC class II and Aire molecules.

语种英语
所属项目编号2010CB945301 ; 2011CB711000 ; 2011CB946100 ; 31070787 ; 30830091 ; NCET-10-0175/BMU20100005 ; 20100001110049
资助者Natural Basic Research Program of China ; National Natural Sciences Foundation of China ; Program for New Century Excellent Talents in University ; Research Fund for the Doctoral Program of Higher Education ; Natural Basic Research Program of China ; National Natural Sciences Foundation of China ; Program for New Century Excellent Talents in University ; Research Fund for the Doctoral Program of Higher Education
WOS记录号WOS:000315100000051
引用统计
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53607
专题基础医学院_免疫学系
作者单位1.Peking Univ, Dept Immunol, Hlth Sci Ctr, Key Lab Med Immunol,Minist Hlth, Beijing 100871, Peoples R China
2.Peking Univ, Med & Hlth Analyt Ctr, Hlth Sci Ctr, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Dong, Jie,Chen, Yu,Xu, Xi,et al. Homeostatic Properties and Phenotypic Maturation of Murine CD4(+) Pre-Thymic Emigrants in the Thymus[J]. PLOS ONE,2013,8(2).
APA Dong, Jie.,Chen, Yu.,Xu, Xi.,Jin, Rong.,Teng, Fei.,...&Ge, Qing.(2013).Homeostatic Properties and Phenotypic Maturation of Murine CD4(+) Pre-Thymic Emigrants in the Thymus.PLOS ONE,8(2).
MLA Dong, Jie,et al."Homeostatic Properties and Phenotypic Maturation of Murine CD4(+) Pre-Thymic Emigrants in the Thymus".PLOS ONE 8.2(2013).
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