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Methylphenidate Normalizes Resting-State Brain Dysfunction in Boys With Attention Deficit Hyperactivity Disorder
An, Li1,2; Cao, Xiao-Hua1,2; Cao, Qing-Jiu1,2; Sun, Li1,2; Yang, Li1,2; Zou, Qi-Hong3,4; Katya, Rubia5; Zang, Yu-Feng6,7; Wang, Yu-Feng1,2
关键词Methylphenidate Hydrochloride (Mph) Attention Deficit Hyperactivity Disorder (Adhd) Resting State Functional Magnetic Resonance Imaging (Fmri) Regional Homogeneity (Reho) Treatment Response Prediction
刊名NEUROPSYCHOPHARMACOLOGY
2013-06-01
DOI10.1038/npp.2013.27
38期:7页:1287-1295
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]FUNCTIONAL MAGNETIC-RESONANCE ; CEREBRAL-BLOOD-FLOW ; DEFICIT/HYPERACTIVITY DISORDER ; REGIONAL HOMOGENEITY ; PREFRONTAL CORTEX ; CHILDREN ; ADHD ; MRI ; FMRI ; MEDICATION
英文摘要

We used resting-state functional magnetic resonance imaging (RS-fMRI) to investigate the acute effects of methylphenidate hydrochloride (MPH) on spontaneous brain activity in children with attention deficit hyperactivity disorder (ADHD). In all, 23 boys with ADHD were scanned twice, under either 10 mg dose of MPH or placebo, in a randomized, cross-over, counterbalanced placebo-controlled design. 32 Matched healthy controls were scanned once for comparison. Seven of the 23 ADHD boys participated in a follow-up 8-week MPH treatment. A regional homogeneity (ReHo) method was applied to characterize the local synchronization of spontaneous brain activity. ADHD boys under placebo compared with controls showed decreased ReHo in bilateral dorsolateral prefrontal cortices and increased ReHo in bilateral sensorimotor and parieto-visual cortices. Relative to placebo, MPH upregulated ReHo in bilateral ventral prefrontal cortices and cerebellar vermis, and downregulated ReHo in right parietal and visual areas that overlapped with the abnormally enhanced activities. When under MPH, ReHo differences between patients and controls were no longer observed. The preliminary prediction analysis revealed that the decreased ReHo in right parietal cortex after the acute MPH was positively correlated with the decreased symptom scores after the 8-week MPH treatment in the seven patients. We show that an acute dose of MPH normalized all fronto-parieto-cerebellar dysfunctions in boys with ADHD during the resting state. Preliminary findings furthermore suggest the potential of RS-fMRI as a prognostic imaging tool to identify response to MPH treatment.

语种英语
WOS记录号WOS:000319120000014
项目编号200802073 ; 2007BAI17B03 ; 30970802 ; 81000593 ; 81020108022
资助机构Commonweal Sciences Foundation, Ministry of Health, China ; National Foundation, Ministry of Science and Technology, China ; National Natural Sciences Foundation, China ; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, China ; Janssen Science Council of China ; Lilly Pharmaceuticals ; Xi&prime ; an Janssen Pharmaceutical
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53609
专题北京大学精神卫生研究所
北京大学精神卫生研究所_精神科
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Peking Univ, MRI Res Ctr, Beijing 100191, Peoples R China
3.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
4.Peking Univ, Beijing Key Lab Med Phys & Engn, Beijing 100191, Peoples R China
5.Kings Coll London, Dept Child Psychiat, Inst Psychiat, London WC2R 2LS, England
6.Hangzhou Normal Univ, Affiliated Hosp, Ctr Cognit & Brain Disorders, Hangzhou, Zhejiang, Peoples R China
7.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
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GB/T 7714
An, Li,Cao, Xiao-Hua,Cao, Qing-Jiu,et al. Methylphenidate Normalizes Resting-State Brain Dysfunction in Boys With Attention Deficit Hyperactivity Disorder[J]. NEUROPSYCHOPHARMACOLOGY,2013,38(7):1287-1295.
APA An, Li.,Cao, Xiao-Hua.,Cao, Qing-Jiu.,Sun, Li.,Yang, Li.,...&Wang, Yu-Feng.(2013).Methylphenidate Normalizes Resting-State Brain Dysfunction in Boys With Attention Deficit Hyperactivity Disorder.NEUROPSYCHOPHARMACOLOGY,38(7),1287-1295.
MLA An, Li,et al."Methylphenidate Normalizes Resting-State Brain Dysfunction in Boys With Attention Deficit Hyperactivity Disorder".NEUROPSYCHOPHARMACOLOGY 38.7(2013):1287-1295.
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