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学科主题: 临床医学
题名:
The mystery of chronic lymphocytic leukemia (CLL): Why is it absent in Asians and what does this tell us about etiology, pathogenesis and biology?
作者: Yang, Shen-Miao1; Li, Jian-Yong2; Gale, Robert Peter3; Huang, Xiao-Jun1,4
关键词: Chronic lymphocytic leukemia ; CLL ; Small lymphocytic lymphoma ; Asians ; IGHV
刊名: BLOOD REVIEWS
发表日期: 2015-05-01
DOI: 10.1016/j.blre.2014.12.001
卷: 29, 期:3, 页:205-213
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: NON-HODGKIN-LYMPHOMA ; IN-SITU HYBRIDIZATION ; H GENE USAGE ; IDENTIFIES RECURRENT MUTATIONS ; ATOMIC-BOMB SURVIVORS ; B-CELL RECEPTORS ; BODY-MASS INDEX ; CHINESE PATIENTS ; LIPOPROTEIN-LIPASE ; MULTIPLE-MYELOMA
英文摘要:

Chronic lymphocytic leukemia/small lymphocytic lymphoma is common in persons of predominately European descent but rare in Asians. Why is unknown but is likely genetically-determined. Environmental factors may also operate but are likely to be less important When CLL occurs in Asians it has different features than CLL in persons of predominately European descent The reason(s) for this is also not understood. We reviewed data on CLL in Asians (mostly Han Chinese but also other ethnic groups) and compared these data with those from persons of predominately European descent with CLL CLL incidence was about 5-10-fold less in Asians. Asians with CLL are younger, have atypical morphologic and immunologic features, an increased proportion of IGHV mutations and rearrangements and briefer freedom-from-progression than persons of predominately European descent with CLL These observations provide clues to the etiology and biology of CLL. But the mystery continues; more research is needed. (C) 2014 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000356644000007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53615
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100871, Peoples R China
2.Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
3.Nanjing Med Univ, Jiangsu Prov Hosp, Affiliated Hosp 1, Dept Hematol, Nanjing 210029, Jiangsu, Peoples R China
4.Univ London Imperial Coll Sci Technol & Med, Dept Med, Div Expt Med, Haematol Res Ctr, London, England

Recommended Citation:
Yang, Shen-Miao,Li, Jian-Yong,Gale, Robert Peter,et al. The mystery of chronic lymphocytic leukemia (CLL): Why is it absent in Asians and what does this tell us about etiology, pathogenesis and biology?[J]. BLOOD REVIEWS,2015,29(3):205-213.
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