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The mystery of chronic lymphocytic leukemia (CLL): Why is it absent in Asians and what does this tell us about etiology, pathogenesis and biology?
Yang, Shen-Miao1; Li, Jian-Yong2; Gale, Robert Peter3; Huang, Xiao-Jun1,4
Source PublicationBLOOD REVIEWS
2015-05-01
Volume29Issue:3Pages:205-213
Indexed BySCI
Abstract

Chronic lymphocytic leukemia/small lymphocytic lymphoma is common in persons of predominately European descent but rare in Asians. Why is unknown but is likely genetically-determined. Environmental factors may also operate but are likely to be less important When CLL occurs in Asians it has different features than CLL in persons of predominately European descent The reason(s) for this is also not understood. We reviewed data on CLL in Asians (mostly Han Chinese but also other ethnic groups) and compared these data with those from persons of predominately European descent with CLL CLL incidence was about 5-10-fold less in Asians. Asians with CLL are younger, have atypical morphologic and immunologic features, an increased proportion of IGHV mutations and rearrangements and briefer freedom-from-progression than persons of predominately European descent with CLL These observations provide clues to the etiology and biology of CLL. But the mystery continues; more research is needed. (C) 2014 Elsevier Ltd. All rights reserved.

KeywordChronic Lymphocytic Leukemia Cll Small Lymphocytic Lymphoma Asians Ighv
Subject Area临床医学
SubtypeReview
DOI10.1016/j.blre.2014.12.001
WOS HeadingsScience & Technology
Language英语
WOS Research AreaHematology
WOS SubjectHematology
WOS KeywordNON-HODGKIN-LYMPHOMA ; IN-SITU HYBRIDIZATION ; H GENE USAGE ; IDENTIFIES RECURRENT MUTATIONS ; ATOMIC-BOMB SURVIVORS ; B-CELL RECEPTORS ; BODY-MASS INDEX ; CHINESE PATIENTS ; LIPOPROTEIN-LIPASE ; MULTIPLE-MYELOMA
WOS IDWOS:000356644000007
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.bjmu.edu.cn/handle/400002259/53615
Collection北京大学第二临床医学院_血液科
Affiliation1.Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100871, Peoples R China
2.Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
3.Nanjing Med Univ, Jiangsu Prov Hosp, Affiliated Hosp 1, Dept Hematol, Nanjing 210029, Jiangsu, Peoples R China
4.Univ London Imperial Coll Sci Technol & Med, Dept Med, Div Expt Med, Haematol Res Ctr, London, England
First Author AffilicationPEKING UNIVERSITY HEALTH SCIENCE CENTER
Recommended Citation
GB/T 7714
Yang, Shen-Miao,Li, Jian-Yong,Gale, Robert Peter,et al. The mystery of chronic lymphocytic leukemia (CLL): Why is it absent in Asians and what does this tell us about etiology, pathogenesis and biology?[J]. BLOOD REVIEWS,2015,29(3):205-213.
APA Yang, Shen-Miao,Li, Jian-Yong,Gale, Robert Peter,&Huang, Xiao-Jun.(2015).The mystery of chronic lymphocytic leukemia (CLL): Why is it absent in Asians and what does this tell us about etiology, pathogenesis and biology?.BLOOD REVIEWS,29(3),205-213.
MLA Yang, Shen-Miao,et al."The mystery of chronic lymphocytic leukemia (CLL): Why is it absent in Asians and what does this tell us about etiology, pathogenesis and biology?".BLOOD REVIEWS 29.3(2015):205-213.
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