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Genomic amplification of the human telomerase RNA gene for differential diagnosis of cervical disorders
Tu, Zheng1; Zhang, Aipeng2; Wu, Ruifang3; Jiang, Jing1; Li, Yali2; Na Wulan3; Li, Jingran1; Zhang, Yongmei2; Li, Yibing3; Chen, Zhong4,5,6; Wei, Lihui1
刊名CANCER GENETICS AND CYTOGENETICS
2009-05-01
DOI10.1016/j.cancergencyto.2009.01.004
191期:1页:10-16
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Genetics & Heredity
资助者Ministry of Health of the People&prime ; s Republic of China ; Ministry of Health of the People&prime ; s Republic of China
研究领域[WOS]Oncology ; Genetics & Heredity
关键词[WOS]SQUAMOUS INTRAEPITHELIAL LESIONS ; HUMAN-PAPILLOMAVIRUS INFECTION ; RISK HUMAN-PAPILLOMAVIRUS ; REVERSE-TRANSCRIPTASE ; UTERINE CERVIX ; HTERT GENE ; HIGH EXPRESSION ; CELL CARCINOMA ; CANCER ; HPV
英文摘要

To evaluate genomic amplification of the human telomerase RNA gene (TERC) as a supportive approach to cytopathology or histopathology in diagnosis of low-grade and high-grade uterine cervical lesions, 1,033 Chinese women at three medical centers had liquid-based thin-layer cytopathologic examination and TERC detection by fluorescence in situ hybridization (FISH). Human papillomavirus DNA testing, colposcopy with or without biopsy, and histopathologic examination were conducted as needed. In cytopathologic examination, genomic amplification of TERC was found in 30 of 659 (4.6%) normal or benign cellular changes; in 23 of 170 (13.5%) atypical squamous cells of undetermined significance (ASCUS); in 8 of 28 (28.6%) atypical squamous cells with high-grade squamous intraepithelial lesion possible (ASC-H); and in 26 of 103 (25.2%) low-grade (LSIL) and 64 of 73 (87.7%) high-grade (HSIL) squamous intraepithelial lesions; with pairwise significant difference (P < 0.05) in each, except ASC-H and LSIL (chi(2) = 0.127, P = 0.72). In histopathologic examination, TERC was amplified in 28 of 671 (4.2%) normal, inflammatory, or wart cases; in 17 of 233 (7.3%) cervical intraepithelial neoplasia grade 1 cases (CIN 1); in 27 of 39 (69.2%) CIN 2 cases; in 57 of 67 (85.1%) CIN 3 cases; and in 22 of 23 (95.7%) cervical cancer cases; with pairwise significant difference in each (P < 0.05). The number of cells with abnormal signals increased and the abnormal signal patterns were diversified with increasing severity of cervical dysplasia. FISH detection of TERC amplification may provide an effective, noninvasive approach in conjunction with cytopathologic or histopathologic evaluation for differential diagnosis of low- and high-grade cervical disorders. (C) 2009 Elsevier Inc. All rights reserved.

语种英语
所属项目编号WKJ 2007-3-001
资助者Ministry of Health of the People&prime ; s Republic of China ; Ministry of Health of the People&prime ; s Republic of China
WOS记录号WOS:000266023700002
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53627
专题北京大学第二临床医学院_妇科
作者单位1.Peking Univ, Peoples Hosp, Dept Gynecol, Beijing 100044, Peoples R China
2.Gen Hosp Peoples Liberty Army, Dept Obstet & Gynecol, Beijing, Peoples R China
3.Peking Univ, Dept Obstet & Gynecol, Shenzhen Hosp, Beijing 100044, Peoples R China
4.Univ Utah, Sch Med, Div Med Genet, Salt Lake City, UT 84112 USA
5.Univ Utah, Sch Med, ARUP Labs, Salt Lake City, UT 84112 USA
6.China Med Technol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Tu, Zheng,Zhang, Aipeng,Wu, Ruifang,et al. Genomic amplification of the human telomerase RNA gene for differential diagnosis of cervical disorders[J]. CANCER GENETICS AND CYTOGENETICS,2009,191(1):10-16.
APA Tu, Zheng.,Zhang, Aipeng.,Wu, Ruifang.,Jiang, Jing.,Li, Yali.,...&Wei, Lihui.(2009).Genomic amplification of the human telomerase RNA gene for differential diagnosis of cervical disorders.CANCER GENETICS AND CYTOGENETICS,191(1),10-16.
MLA Tu, Zheng,et al."Genomic amplification of the human telomerase RNA gene for differential diagnosis of cervical disorders".CANCER GENETICS AND CYTOGENETICS 191.1(2009):10-16.
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