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学科主题: 临床医学
题名:
Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease
作者: Ma, Ying-Chun; Zuo, Li; Chen, Jiang-Hua; Luo, Qiong; Yu, Xue-Qing; Li, Ying; Xu, Jin-Sheng; Huang, Song-Min; Wang, Li-Ning; Huang, Wen; Wang, Mei; Xu, Guo-Bin; Wang, Hai-Yan; Chinese eGFR Invest Collaboration
刊名: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
发表日期: 2006-10-01
DOI: 10.1681/ASN.2006040368
卷: 17, 期:10, 页:2937-2944
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: SERUM CREATININE ; PLASMA-CLEARANCE ; RENAL-FUNCTION ; GFR ; MARKER ; IOTHALAMATE ; ADULTS ; HEALTH ; DTPA
英文摘要:

The Modification of Diet in Renal Disease (MDRD) equations provide a rapid method of assessing GFR in patients with chronic kidney disease (CKD). However, previous research indicated that modification of these equations is necessary for application in Chinese patients with CKD. The objective of this study was to modify MDRD equations on the basis of the data from the Chinese CKD population and compare the diagnostic performance of the modified MDRD equations with that of the original MDRD equations across CKD stages in a multicenter, cross-sectional study of GFR estimation from plasma creatinine, demographic data, and clinical characteristics. A total of 684 adult patients with CKD, from nine geographic regions of China were selected. A random sample of 454 of these patients were included in the training sample set, and the remaining 230 patients were included in the testing sample set. With the use of the dual plasma sampling Tc-99m-DTPA plasma clearance method as a reference for GFR measurement, the original MDRD equations were modified by two methods: First, by adding a racial factor for Chinese in the original MDRD equations, and, second, by applying multiple linear regression to the training sample and modifying the coefficient that is associated with each variable in the original MDRD equations and then validating in the testing sample and comparing it with the original MDRD equations. All modified MDRD equations showed significant performance improvement in bias, precision, and accuracy compared with the original MDRD equations, and the percentage of estimated GFR that did not deviate > 30% from the reference GFR was > 75%. The modified MDRD equations that were based on the Chinese patients with CKD offered significant advantages in different CKD stages and could be applied in clinical practice, at least in Chinese patients with CKD.

语种: 英语
WOS记录号: WOS:000240926500034
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53628
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Div Nephrol, Beijing 100034, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China
3.Peking Univ, Dept Clin Lab, Hosp 1, Beijing 100871, Peoples R China
4.First Hosp, Zhejang Med Coll, Dept Nephrol, Zhejiang, Peoples R China
5.Peking Univ, ShenZhen Hosp, Dept Nephrol, Shenzhen, Peoples R China
6.Sun Yat Sen Univ, Hosp 1, Dept Nephrol, Guangzhou, Peoples R China
7.Hebei Med Univ, Hosp 3, Dept Nephrol, Shijia Zhuang, Peoples R China
8.Third Hosp, Dept Nephrol, Shijia Zhuang, Peoples R China
9.SiChuan Univ, HuaXi Hosp, Dept Nephrol, Chengdu, Peoples R China
10.China Med Univ, Hosp 1, Dept Nephrol, Shenyang, Peoples R China
11.Capital Med Univ, TongRen Hosp, Dept Nephrol, Beijing, Peoples R China

Recommended Citation:
Ma, Ying-Chun,Zuo, Li,Chen, Jiang-Hua,et al. Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease[J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,2006,17(10):2937-2944.
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