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学科主题: 临床医学
题名:
Proteomic analysis of proteins with altered expression induced by phenylephrine in neonatal rat cardiomyocyte
作者: Liu, N; Li, ZJ; Liu, ZQ; Liu, SY; Han, QD; Zhang, YY
关键词: phenylephrine ; cardiomyocyte ; proteome
刊名: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
发表日期: 2006-01-10
卷: 27, 期:1, 页:79-81
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: IDENTIFICATION
英文摘要:

In order to find candidate proteins that are potentially associated with the phenotype in neonatal rat car diomyocytes treated with phenylephrine(PE), the differential proteins expression pattern after a-adrenergic receptor stimulation in neonatal cardiomyocytes was analyzed by using a series of methods, including two dimensional polyacrylamide gel electrophoresis, PDQuest 2-DE software analysis and peptide mass fingerprint mapping based on MALDI-TOF-MS. The good two-dimensional pattern with a high resolution and reproducibility was obtained. Totally 14 differential protein spots were found. Put of these, 11 proteins were preliminarily identified. Desmin, Txndc5, etc. were found to be up-regulated in PE-treated cardiomyocytes, while caspase-11, 4-hydroxyphenylpyruvic acid dioxygenase, etc. were found to be down-regulated. It suggests that the differential expression analysis of proteome may be useful to the further study of the related proteins and the molecular markers of cardiovascular diseases.

语种: 中文
WOS记录号: WOS:000234815500021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53629
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Chinese Acad Sci, Changchun Inst Appl Chem, Lab New Drug Res & Mass Spectrometry, Changchun Ctr Mass Spectrometry, Changchun 130022, Peoples R China
2.Peking Univ, Inst Vasc Med, Hosp 3, Key Lab Mol Cardiovasc Sci,Minist Educ, Beijing 100083, Peoples R China

Recommended Citation:
Liu, N,Li, ZJ,Liu, ZQ,et al. Proteomic analysis of proteins with altered expression induced by phenylephrine in neonatal rat cardiomyocyte[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2006,27(1):79-81.
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