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学科主题: 临床医学
题名:
A novel molecular marker of prognosis in colorectal cancer: Vasohibin-1
作者: Yan, Yichao1; Shen, Zhanlong1; Ye, Yingjiang1; Jiang, Kewei1; Zhang, Hui1; Shen, Chao1; Mustonen, Harri2; Puolakkainen, Pauli2; Wang, Shan1
关键词: Vasohibin-1 ; Colorectal cancer ; Invasion ; Metastasis ; Prognosis
刊名: MEDICAL ONCOLOGY
发表日期: 2014-02-01
DOI: 10.1007/s12032-013-0816-0
卷: 31, 期:2
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: EPITHELIUM-DERIVED FACTOR ; ANGIOGENESIS INHIBITOR ; ENDOTHELIAL-CELLS ; CHONDROMODULIN-I ; EXPRESSION ; NEOVASCULARIZATION ; MECHANISMS ; CARCINOMA ; DISEASE ; SWITCH
英文摘要:

Vasohibin-1 has been recently detected in endothelial cells and identified as a negative feedback regulator of angiogenesis induced by VEGF-A. However, the expression of Vasohibin-1 in colorectal cancer and its correlations with VEGF-A, microvessel density (MVD), and the prognosis of the patients remain unclear. In this study, Vasohibin-1 and VEGF-A expression were measured in 132 paraffin-embedded tissues of colorectal cancer by immunohistochemistry and Western blot, as well as in colon cancer cell lines with different metastatic potential and in normal colon cell by Western blot and real-time PCR. MVD was measured by counting CD34 positive clusters in a single field of view with the most intensive neovascularization of colon cancer tissues. The correlation between the expression of Vasohibin-1, VEGF-A, MVD, clinicopathological features, and prognosis was analyzed. We found that Vasohibin-1 and VEGF-A proteins were expressed in 88.64 % (117/132) and 84.09 % (111/132) colorectal cancer tissues, respectively. Strongly positive correlations were found between Vasohibin-1, VEGF-A expression, and MVD in the colorectal cancer tissues (Vasohibin-1 vs. VEGF-A: r = 0.688, P < 0.001; Vasohibin-1 vs. MVD: r = 0.483, P < 0.001; VEGF-A vs. MVD: r = 0.491, P < 0.001). Vasohibin-1 expression has significant positive correlation with pathological TNM stage (P = 0.001), tumor stromal invasion (P = 0.004), lymph node status (P = 0.003), and distant metastasis (P = 0.033), but no correlation with tumor differentiation (P = 0.756). The patients with high Vasohibin-1 expression had significantly worse overall survival (OS) and progression-free survival (PFS) than those with low Vasohibin-1 expression (OS: P = 0.001; PFS: P = 0.003). In addition, Vasohibin-1 protein expression is an independent risk factor affecting OS and PFS. Therefore, we conclude that Vasohibin-1 is a clinically relevant predictor of patient prognosis in colorectal cancer. Vasohibin-1 might become a new biomarker and provide additional prognostic information in patients with colorectal cancer.

语种: 英语
所属项目编号: 81372290 ; 81372291 ; 7112136 ; 2107000074 ; RDB 2012-18 ; RDB 2013-15
项目资助者: National Natural Science Foundation ; Beijing Municipal Natural Science Foundation ; Beijing Science and Technology Project ; Peking University People&prime ; s Hospital Research and Development Funds
WOS记录号: WOS:000331977900006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53638
Appears in Collections:北京大学第二临床医学院_胃肠外科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Surg Gastroenterol, Beijing 100044, Peoples R China
2.Univ Helsinki, Cent Hosp, Dept Surg, FIN-00290 Helsinki, Finland

Recommended Citation:
Yan, Yichao,Shen, Zhanlong,Ye, Yingjiang,et al. A novel molecular marker of prognosis in colorectal cancer: Vasohibin-1[J]. MEDICAL ONCOLOGY,2014,31(2).
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