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学科主题基础医学
Extracellular ATP enhances in vitro invasion of prostate cancer cells by activating Rho GTPase and upregulating MMPs expression
Zhang, Yang1; Gong, Li-hua1; Zhang, Hong-quan2,3; Du, Qiang1; You, Jiang-feng1; Tian, Xin-xia1; Fang, Wei-gang1
关键词ATP Prostate cancer Invasion Rho GTPase MMP
刊名CANCER LETTERS
2010-07-28
DOI10.1016/j.canlet.2010.01.010
293期:2页:189-197
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]RANDOMIZED CLINICAL-TRIAL ; HUMAN-TUMOR CELLS ; LUNG-CANCER ; ADENOSINE 5&prime ; -TRIPHOSPHATE ; GROWTH-INHIBITION ; HUMAN NEUTROPHILS ; CARCINOMA-CELLS ; RECEPTOR ; RELEASE ; VIVO
英文摘要

We previously found that in addition to anti-proliferation function, extracellular ATP had a pro-invasion effect on prostate cancer cells, and probably serves as an important regulator of invasion in local microenvironment. However, the underlying mechanism remains unclear. In this study, we demonstrated that ATP increased the motility of prostate cancer cells, and promoted formation of lamellipodia and filopodia. We also found that ATP induced activation of Rac1 and Cdc42, and promoted expression of MMP-3 and MMP-13. These data suggest that extracellular ATP enhances the invasion of prostate cancer cells by activating Rho GTPases Rac1 and Cdc42 and upregulating MMPs expression. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000278600400007
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53642
Collection北京大学基础医学院_病理学系
北京大学医学部管理机构_主任办公室党委办公室
北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Pathol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Histol, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Embryol, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Yang,Gong, Li-hua,Zhang, Hong-quan,et al. Extracellular ATP enhances in vitro invasion of prostate cancer cells by activating Rho GTPase and upregulating MMPs expression[J]. CANCER LETTERS,2010,293(2):189-197.
APA Zhang, Yang.,Gong, Li-hua.,Zhang, Hong-quan.,Du, Qiang.,You, Jiang-feng.,...&Fang, Wei-gang.(2010).Extracellular ATP enhances in vitro invasion of prostate cancer cells by activating Rho GTPase and upregulating MMPs expression.CANCER LETTERS,293(2),189-197.
MLA Zhang, Yang,et al."Extracellular ATP enhances in vitro invasion of prostate cancer cells by activating Rho GTPase and upregulating MMPs expression".CANCER LETTERS 293.2(2010):189-197.
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