IR@PKUHSC  > 基础医学院  > 病理学系
学科主题基础医学
Extracellular ATP enhances in vitro invasion of prostate cancer cells by activating Rho GTPase and upregulating MMPs expression
Zhang, Yang1; Gong, Li-hua1; Zhang, Hong-quan2,3; Du, Qiang1; You, Jiang-feng1; Tian, Xin-xia1; Fang, Wei-gang1
关键词ATP Prostate cancer Invasion Rho GTPase MMP
刊名CANCER LETTERS
2010-07-28
DOI10.1016/j.canlet.2010.01.010
293期:2页:189-197
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者National Natural Science Foundation of China ; Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Ministry of Science and Technology of China
研究领域[WOS]Oncology
关键词[WOS]RANDOMIZED CLINICAL-TRIAL ; HUMAN-TUMOR CELLS ; LUNG-CANCER ; ADENOSINE 5&prime ; -TRIPHOSPHATE ; GROWTH-INHIBITION ; HUMAN NEUTROPHILS ; CARCINOMA-CELLS ; RECEPTOR ; RELEASE ; VIVO
英文摘要

We previously found that in addition to anti-proliferation function, extracellular ATP had a pro-invasion effect on prostate cancer cells, and probably serves as an important regulator of invasion in local microenvironment. However, the underlying mechanism remains unclear. In this study, we demonstrated that ATP increased the motility of prostate cancer cells, and promoted formation of lamellipodia and filopodia. We also found that ATP induced activation of Rac1 and Cdc42, and promoted expression of MMP-3 and MMP-13. These data suggest that extracellular ATP enhances the invasion of prostate cancer cells by activating Rho GTPases Rac1 and Cdc42 and upregulating MMPs expression. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

语种英语
所属项目编号30471936 ; 2010CB529402
资助者National Natural Science Foundation of China ; Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Ministry of Science and Technology of China
WOS记录号WOS:000278600400007
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53642
专题基础医学院_病理学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Pathol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Histol, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Embryol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Yang,Gong, Li-hua,Zhang, Hong-quan,et al. Extracellular ATP enhances in vitro invasion of prostate cancer cells by activating Rho GTPase and upregulating MMPs expression[J]. CANCER LETTERS,2010,293(2):189-197.
APA Zhang, Yang.,Gong, Li-hua.,Zhang, Hong-quan.,Du, Qiang.,You, Jiang-feng.,...&Fang, Wei-gang.(2010).Extracellular ATP enhances in vitro invasion of prostate cancer cells by activating Rho GTPase and upregulating MMPs expression.CANCER LETTERS,293(2),189-197.
MLA Zhang, Yang,et al."Extracellular ATP enhances in vitro invasion of prostate cancer cells by activating Rho GTPase and upregulating MMPs expression".CANCER LETTERS 293.2(2010):189-197.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Extracellular ATP en(1931KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Yang]的文章
[Gong, Li-hua]的文章
[Zhang, Hong-quan]的文章
百度学术
百度学术中相似的文章
[Zhang, Yang]的文章
[Gong, Li-hua]的文章
[Zhang, Hong-quan]的文章
必应学术
必应学术中相似的文章
[Zhang, Yang]的文章
[Gong, Li-hua]的文章
[Zhang, Hong-quan]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Extracellular ATP enhances in vitro invasion of prostate cancer cells by activating Rho GTPase and upregulating MMPs expression.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。