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学科主题: 基础医学
题名:
Extracellular ATP enhances in vitro invasion of prostate cancer cells by activating Rho GTPase and upregulating MMPs expression
作者: Zhang, Yang1; Gong, Li-hua1; Zhang, Hong-quan2,3; Du, Qiang1; You, Jiang-feng1; Tian, Xin-xia1; Fang, Wei-gang1
关键词: ATP ; Prostate cancer ; Invasion ; Rho GTPase ; MMP
刊名: CANCER LETTERS
发表日期: 2010-07-28
DOI: 10.1016/j.canlet.2010.01.010
卷: 293, 期:2, 页:189-197
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: RANDOMIZED CLINICAL-TRIAL ; HUMAN-TUMOR CELLS ; LUNG-CANCER ; ADENOSINE 5&prime ; -TRIPHOSPHATE ; GROWTH-INHIBITION ; HUMAN NEUTROPHILS ; CARCINOMA-CELLS ; RECEPTOR ; RELEASE ; VIVO
英文摘要:

We previously found that in addition to anti-proliferation function, extracellular ATP had a pro-invasion effect on prostate cancer cells, and probably serves as an important regulator of invasion in local microenvironment. However, the underlying mechanism remains unclear. In this study, we demonstrated that ATP increased the motility of prostate cancer cells, and promoted formation of lamellipodia and filopodia. We also found that ATP induced activation of Rac1 and Cdc42, and promoted expression of MMP-3 and MMP-13. These data suggest that extracellular ATP enhances the invasion of prostate cancer cells by activating Rho GTPases Rac1 and Cdc42 and upregulating MMPs expression. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 30471936 ; 2010CB529402
项目资助者: National Natural Science Foundation of China ; Ministry of Science and Technology of China
WOS记录号: WOS:000278600400007
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53642
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Pathol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Histol, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Embryol, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Yang,Gong, Li-hua,Zhang, Hong-quan,et al. Extracellular ATP enhances in vitro invasion of prostate cancer cells by activating Rho GTPase and upregulating MMPs expression[J]. CANCER LETTERS,2010,293(2):189-197.
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