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学科主题: 基础医学
题名:
Kindlin-2 interacts with alpha-actinin-2 and beta 1 integrin to maintain the integrity of the Z-disc in cardiac muscles
作者: Qi, Lihua1,2,3; Yu, Yu1,2,3; Chi, Xiaochun1,2,3; Xu, Weizhi1,2,3; Lu, Danyu1,2,3; Song, Yao4; Zhang, Youyi4; Zhang, Hongquan1,2,3
关键词: Kindlin-2 ; alpha-Actinin-2 ; The Z-disc ; Cardiac structure
刊名: FEBS LETTERS
发表日期: 2015-07-22
DOI: 10.1016/j.febslet.2015.06.022
卷: 589, 期:16, 页:2155-2162
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]: ALPHA-ACTININ ; HYPERTROPHIC CARDIOMYOPATHY ; DILATED CARDIOMYOPATHY ; INTERCALATED DISCS ; PROTEIN ; ACTIVATION ; COMPLEX ; FAMILY ; GENE ; MYOGENESIS
英文摘要:

Kindlin-2, as an integrin-interacting protein, was known to be required for the maintenance of cardiac structure and function in zebrafish. However, the mechanism remains unclear. We found that Kindlin-2 interacts and colocalizes with alpha-actinin-2 at the Z-disc of mouse cardiac muscles and there Kindlin-2 also interacts with beta 1 integrin. Knockdown of Kindlin-2 influences the association of beta 1 integrin with alpha-actinin-2 and disrupts the structure of the Z-disc and leads to cardiac dysfunction. Our data indicated that Kindlin-2 is a novel alpha-actinin-2-interacting protein and plays an important role in the regulation of cardiac structure and function. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 81230051 ; 81472734 ; 31170711 ; 81101495 ; 81321003 ; 30830048 ; 2015CB553906 ; 2013CB910501 ; 2010CB912203 ; 7120002 ; BMU20120314 ; BMU20130364
项目资助者: National Natural Science Foundation of China ; Ministry of Science and Technology of China ; 111 Project of the Ministry of Education ; Beijing Natural Science Foundation ; Peking University ; Leading Academic Discipline Project of Beijing Education Bureau
WOS记录号: WOS:000358805100018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53643
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Peking Univ, Key Lab Carcinogenesis & Translat Res, Minist Educ, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Hlth Sci Ctr, Beijing 100191, Peoples R China
3.Peking Univ, Dept Anat Histol & Embryol, Hlth Sci Ctr, Beijing 100191, Peoples R China
4.Peking Univ, Inst Cardiovasc Res, Hlth Sci Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Qi, Lihua,Yu, Yu,Chi, Xiaochun,et al. Kindlin-2 interacts with alpha-actinin-2 and beta 1 integrin to maintain the integrity of the Z-disc in cardiac muscles[J]. FEBS LETTERS,2015,589(16):2155-2162.
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