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学科主题基础医学
`s\vl VE`s\vl Vlpha-actinin-2 and beta 1 integrin to maintain the integrity of the Z-disc in cardiac muscles
Qi, Lihua1,2,3; Yu, Yu1,2,3; Chi, Xiaochun1,2,3; Xu, Weizhi1,2,3; Lu, Danyu1,2,3; Song, Yao4; Zhang, Youyi4; Zhang, Hongquan1,2,3
关键词Kindlin-2 Alpha-actinin-2 The Z-disc Cardiac Structure
刊名FEBS LETTERS
2015-07-22
DOI10.1016/j.febslet.2015.06.022
589期:16页:2155-2162
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]ALPHA-ACTININ ; HYPERTROPHIC CARDIOMYOPATHY ; DILATED CARDIOMYOPATHY ; INTERCALATED DISCS ; PROTEIN ; ACTIVATION ; COMPLEX ; FAMILY ; GENE ; MYOGENESIS
英文摘要

Kindlin-2, as an integrin-interacting protein, was known to be required for the maintenance of cardiac structure and function in zebrafish. However, the mechanism remains unclear. We found that Kindlin-2 interacts and colocalizes with alpha-actinin-2 at the Z-disc of mouse cardiac muscles and there Kindlin-2 also interacts with beta 1 integrin. Knockdown of Kindlin-2 influences the association of beta 1 integrin with alpha-actinin-2 and disrupts the structure of the Z-disc and leads to cardiac dysfunction. Our data indicated that Kindlin-2 is a novel alpha-actinin-2-interacting protein and plays an important role in the regulation of cardiac structure and function. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000358805100018
项目编号81230051 ; 81472734 ; 31170711 ; 81101495 ; 81321003 ; 30830048 ; 2015CB553906 ; 2013CB910501 ; 2010CB912203 ; 7120002 ; BMU20120314 ; BMU20130364
资助机构National Natural Science Foundation of China ; Ministry of Science and Technology of China ; 111 Project of the Ministry of Education ; Beijing Natural Science Foundation ; Peking University ; Leading Academic Discipline Project of Beijing Education Bureau
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53643
专题北京大学基础医学院_心血管所
北京大学基础医学院
北京大学第三临床医学院_心血管内科
作者单位1.Peking Univ, Key Lab Carcinogenesis & Translat Res, Minist Educ, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Hlth Sci Ctr, Beijing 100191, Peoples R China
3.Peking Univ, Dept Anat Histol & Embryol, Hlth Sci Ctr, Beijing 100191, Peoples R China
4.Peking Univ, Inst Cardiovasc Res, Hlth Sci Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Qi, Lihua,Yu, Yu,Chi, Xiaochun,et al. Kindlin-2 interacts with alpha-actinin-2 and beta 1 integrin to maintain the integrity of the Z-disc in cardiac muscles[J]. FEBS LETTERS,2015,589(16):2155-2162.
APA Qi, Lihua.,Yu, Yu.,Chi, Xiaochun.,Xu, Weizhi.,Lu, Danyu.,...&Zhang, Hongquan.(2015).Kindlin-2 interacts with alpha-actinin-2 and beta 1 integrin to maintain the integrity of the Z-disc in cardiac muscles.FEBS LETTERS,589(16),2155-2162.
MLA Qi, Lihua,et al."Kindlin-2 interacts with alpha-actinin-2 and beta 1 integrin to maintain the integrity of the Z-disc in cardiac muscles".FEBS LETTERS 589.16(2015):2155-2162.
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