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The macrostructural and microstructural abnormalities of corpus callosum in children with attention deficit/hyperactivity disorder: A combined morphometric and diffusion tensor MRI study
Cao, Qingjiu2,3; Sun, Li2,3; Gong, Gaolang4; Lv, Yating1; Cao, Xiaohua2,3; Shuai, Lan2,3; Zhu, Chaozhe1; Zang, Yufeng1; Wang, Yufeng2,3
关键词Attention-deficit/hyperactivity Disorder Corpus Callosum Magnetic Resonance Imaging Diffusion Tensor Imaging Fractional Anisotropy Isthmus
刊名BRAIN RESEARCH
2010-01-15
DOI10.1016/j.brainres.2009.10.031
1310页:172-180
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]DEFICIT-HYPERACTIVITY DISORDER ; WHITE-MATTER ; FMRI EVIDENCE ; ADHD ; MORPHOLOGY ; ADULTS ; ADOLESCENTS ; CHILDHOOD ; SCHIZOPHRENIA ; METAANALYSIS
英文摘要

The corpus callosum (CC) is one of focused target areas which may play an important role in the pathophysiology of attention deficit hyperactivity disorder (ADHD). Conventional structural magnetic resonance imaging (MRI) studies have revealed the macrostructural abnormalities of CC and its subdivisions in ADHD compared with controls. However, no study has examined the macrostructural and micro structural characteristics of the CC in the same ADHD group. In this study, MRI morphometric and diffusion tensor imaging (DTI) techniques were combined to explore the area and measure fractional anisotropy (FA) abnormality of CC and its seven subdivisions in children with ADHD. Twenty-eight boys with ADHD (13.3 +/- 1.5 years) and 27 age- and gender- matched controls (13.2 +/- 0.9 years) were included. We co-registered individual structural MRI and DTI images manually and subdivided the midsagittal CC into seven subdivisions. The area and FA of the CC and its subdivisions were then compared between the patients and the matched controls. Results showed that ADHD had decreased area of entire CC, anterior middle-body, and isthmus. Meanwhile, reduced FA value of the isthmus was found in the ADHD group compared with the controls. our study indicated that not only macrostructural abnormalities but also microstructural alterations in CC, especially in isthmus occurred in ADHD. The abnormality of the isthmus, the subdivision that contains the fibers connecting posterior regions of brain, may play an important role in the pathophysiology of ADHD and maybe implicated in the disorders of attention. (C) 2009 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000274450900017
项目编号30770774 ; 200802073 ; 2007BAI17B03 ; 30621130074 ; 2008AA02Z405
资助机构National Natural Sciences Foundation of China ; Common-weal Sciences Foundation, Ministry of Health, China ; National Foundation, Ministry of Science and Technology, China ; NSFC ; 863 program
引用统计
被引频次:46[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53647
专题北京大学精神卫生研究所
北京大学精神卫生研究所_精神科
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
3.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
4.McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ, Canada
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Cao, Qingjiu,Sun, Li,Gong, Gaolang,et al. The macrostructural and microstructural abnormalities of corpus callosum in children with attention deficit/hyperactivity disorder: A combined morphometric and diffusion tensor MRI study[J]. BRAIN RESEARCH,2010,1310:172-180.
APA Cao, Qingjiu.,Sun, Li.,Gong, Gaolang.,Lv, Yating.,Cao, Xiaohua.,...&Wang, Yufeng.(2010).The macrostructural and microstructural abnormalities of corpus callosum in children with attention deficit/hyperactivity disorder: A combined morphometric and diffusion tensor MRI study.BRAIN RESEARCH,1310,172-180.
MLA Cao, Qingjiu,et al."The macrostructural and microstructural abnormalities of corpus callosum in children with attention deficit/hyperactivity disorder: A combined morphometric and diffusion tensor MRI study".BRAIN RESEARCH 1310(2010):172-180.
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