IR@PKUHSC  > 北京大学基础医学院  > 生物物理学系
学科主题基础医学
Studies on the biomechanical properties of maturing reticulocytes
Xie, LD; Jiang, YH; Yao, WJ; Gu, L; Sun, DG; Ka, WB; Wen, ZY; Chien, S
关键词reticulocyte membrane fluidity viscoelasticity secondary structure
刊名JOURNAL OF BIOMECHANICS
2006
DOI10.1016/j.jbiomech.2004.11.032
39期:3页:530-535
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biophysics ; Engineering, Biomedical
研究领域[WOS]Biophysics ; Engineering
关键词[WOS]SHEAR-FLOW FIELD ; LOW-VISCOSITY ; RBC MEMBRANE ; ORIENTATION ; EKTACYTOMETRY ; CELLS
英文摘要

We investigated the biomechanical properties of reticulocytes obtained from an animal model of hemolytic anemia induced by antibody injection. The hemorheological indices, membrane viscoelasticity, membrane fluidity, and the secondary structure of membrane proteins of the reticulocytes were monitored continuously during the course of their maturation into erythrocytes. The results indicate that reticulocytes had lower deformability, lower membrane fluidity, greater viscoelastic modulus and lesser proportions of alpha-helices and beta-sheets in protein secondary structures than mature erythrocytes. All these indices approached to the level of normal erythrocytes when reticulocytes transformed during maturation. The results help to enhance our understanding of the biomechanical properties of the reticulocytes in their maturing process with clinical diagnosis significances. (c) 2005 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000234869600015
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53648
Collection北京大学基础医学院_生物物理学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Biophys, Hemorheol Ctr, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Med Phys, Beijing 100083, Peoples R China
3.Univ Calif San Diego, Dept Bioengn, San Diego, CA USA
4.Univ Calif San Diego, Whitaker Inst Biomed Engn, San Diego, CA USA
Recommended Citation
GB/T 7714
Xie, LD,Jiang, YH,Yao, WJ,et al. Studies on the biomechanical properties of maturing reticulocytes[J]. JOURNAL OF BIOMECHANICS,2006,39(3):530-535.
APA Xie, LD.,Jiang, YH.,Yao, WJ.,Gu, L.,Sun, DG.,...&Chien, S.(2006).Studies on the biomechanical properties of maturing reticulocytes.JOURNAL OF BIOMECHANICS,39(3),530-535.
MLA Xie, LD,et al."Studies on the biomechanical properties of maturing reticulocytes".JOURNAL OF BIOMECHANICS 39.3(2006):530-535.
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