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Brachytherapy for recurrent malignant tumours of the parotid gland
Zhang, J.; Zheng, L.; Liu, S. -m.; Huang, M. -w.; Shi, Y.; Wang, W.; Zhang, J. -g.
关键词Parotid Gland Recurrence Radioactive Seed
刊名BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
2015
DOI10.1016/j.bjoms.2014.09.016
53期:1页:58-62
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine ; Surgery
研究领域[WOS]Dentistry, Oral Surgery & Medicine ; Surgery
关键词[WOS]POSTOPERATIVE RADIATION-THERAPY ; SEED IMPLANT BRACHYTHERAPY ; ADENOID CYSTIC CARCINOMA ; SINGLE-CENTER EXPERIENCE ; PROGNOSTIC-FACTORS ; PROSTATE-CANCER ; SALVAGE SURGERY ; NECK-CANCER ; RADIOTHERAPY ; HEAD
英文摘要

To find out if brachytherapy with radioactive seeds was effective in patients with recurrent malignant tumours of the parotid gland we retrospectively studied 64 such patients, 24 of whom were treated with implantation of radioactive seeds alone, and 40 of whom had their recurrent tumours resected followed by implantation of radioactive seeds. Patients were followed up for a mean of 50 months (range 4 months to 12 years). The local control rate was 76.6%, and overall survival 79.7%. Of the 24 patients treated with brachytherapy alone, 22 achieved a complete response(91.7%). At 1,3, and 5 years the local control rates were 81.5%, 67.2%, and 53.8%, respectively, and the overall survival 82.7%, 70%, and 61.2%, respectively. In the 40 patients whose tumours were resected before brachytherapy, the local control rates at 1,3, and 5 years were 87.5%, 82.4%, and 78.6%, respectively, and the overall survival was 97.5%, 86.5%, and 86.5%, respectively. Sex, age, histopathological grade, size of tumour, history of radiotherapy, time of recurrence and method of treatment were not shown to have a significant effect on local control, but method of treatment had a significant impact on overall survival (p = 0.008). We conclude that treatment of recurrent malignant tumours of the parotid efficacy can be successfully treated with brachytherapy with radioactive seeds, either aloneor combined with resection. (C) 2014 The British Association of Oraland Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000346570500013
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53649
专题北京大学口腔医学院
北京大学基础医学院
北京大学口腔医学院_外科
北京大学临床肿瘤学院_肝胆胰外二科
作者单位Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhang, J.,Zheng, L.,Liu, S. -m.,et al. Brachytherapy for recurrent malignant tumours of the parotid gland[J]. BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY,2015,53(1):58-62.
APA Zhang, J..,Zheng, L..,Liu, S. -m..,Huang, M. -w..,Shi, Y..,...&Zhang, J. -g..(2015).Brachytherapy for recurrent malignant tumours of the parotid gland.BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY,53(1),58-62.
MLA Zhang, J.,et al."Brachytherapy for recurrent malignant tumours of the parotid gland".BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY 53.1(2015):58-62.
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