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学科主题: 药学
题名:
Therapeutic effects of lactosyl derivative Gu-4 in a collagen-induced arthritis rat model
作者: Fan, Jie1; Zhou, Huiting1; Wang, Shihui1; Wang, Hailian1; Zhang, Yushun1; Guo, Yingtao1; Li, Qing2; Li, Zhongjun2; Zhao, Zhihui1
关键词: Collagen-induced arthritis ; Gu-4 ; Rheumatoid arthritis ; Rheumatoid factor ; Lymphocyte proliferation
刊名: GLYCOCONJUGATE JOURNAL
发表日期: 2012-08-01
DOI: 10.1007/s10719-012-9407-0
卷: 29, 期:5-6, 页:305-313
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: RHEUMATOID-ARTHRITIS ; B-CELLS ; INFLAMMATION ; NEUTROPHILS ; ANTIBODIES ; INITIATION ; INDUCTION ; DIAGNOSIS ; EFFICACY
英文摘要:

Rheumatoid arthritis (RA) is an inflammatory disorder that is characterized by persistent recurrence of joint inflammation leading to cartilage and bone destruction. The present anti-arthritis therapies failed to achieve satisfactory remission in all patients; therefore, it is still necessary to develop novel approaches to fulfill the demand in clinic. Here, we reported the therapeutic effects of lactosyl derivative Gu-4, a synthetic compound that was previously identified as a selective inhibitor against leukocyte integrin CD11b, in a bovine type II collagen induced arthritis (CIA) rat model. First, prophylactic administration of Gu-4 (1.2728 mg/kg) to rats by intraperitoneal injection every 2 days from the first day of collagen immunization significantly decreased the incidence of CIA, diminished the mean paw volume increase, and reduced the number of swollen paws. Second, administration of Gu-4 (1.2728 mg/kg) to rats at early-onset stage of CIA prevented the progression of the pathological process of RA, accelerated the remission of paw edema, and declined the arthritis score; after 5 weeks treatment, X-ray and histological examinations were carried out, the ankle joint of hind limb of Gu-4 treated CIA rats exhibited slighter bone erosion and much less inflammatory cell infiltration compared to those of saline treated animals; furthermore, Gu-4 remarkably attenuated the production of rheumatoid factor (RF) in the serum of CIA rats as determined by ELISA. Moreover, we performed in vitro lymphocyte proliferation assay and found that Gu-4 significantly inhibited the proliferation of splenic lymphocytes isolated from CIA rats in a dose-dependent manner. Our results suggest that Gu-4 can effectively ameliorate CIA and might be an alternative option for the treatment of RA.

语种: 英语
所属项目编号: 2008104GZ40166 ; 2009ZX09103-044
项目资助者: Natural Science Foundation of China ; State New Drug Innovation Plan ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
WOS记录号: WOS:000307763900008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53652
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Nanjing Normal Univ, Coll Life Sci, Jiangsu Prov Key Lab Mol & Med Biotechnol, Nanjing 210046, Jiangsu, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Fan, Jie,Zhou, Huiting,Wang, Shihui,et al. Therapeutic effects of lactosyl derivative Gu-4 in a collagen-induced arthritis rat model[J]. GLYCOCONJUGATE JOURNAL,2012,29(5-6):305-313.
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