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Endogenous sulfur dioxide protects against isoproterenol-induced myocardial injury and increases myocardial antioxidant capacity in rats
Liang, Yinfang1; Liu, Die1; Ochs, Todd2; Tang, Chaoshu3,4; Chen, Stella5; Zhang, Suqing1; Geng, Bin3,4; Jin, Hongfang1; Du, Junbao1,4
关键词Antioxidant Capacity Isoproterenol Myocardial Injury Sulfur Dioxide
刊名LABORATORY INVESTIGATION
2011
DOI10.1038/labinvest.2010.156
91期:1页:12-23
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pathology
资助者National Natural Science Foundation of China ; Ministry of Education, China ; Major Basic Research Program of China ; National Natural Science Foundation of China ; Ministry of Education, China ; Major Basic Research Program of China
研究领域[WOS]Research & Experimental Medicine ; Pathology
关键词[WOS]OXIDATIVE STRESS ; AIR-POLLUTION ; SUPEROXIDE-PRODUCTION ; NAD(P)H OXIDASE ; BLOOD-PRESSURE ; SERUM SULFITE ; HEART ; MITOCHONDRIA ; REPERFUSION ; ISCHEMIA
英文摘要

Recently, sulfur dioxide (SO(2)) was discovered to be produced in the cardiovascular system and to influence important biological processes. Here, we investigated changes in endogenous SO(2)/glutamic oxaloacetic transaminase (GOT) pathway in the development of isoproterenol (ISO)-induced myocardial injury in rats and the regulatory effect of SO(2) on cardiac function, myocardial micro-and ultrastructure, and oxidative stress. Wistar male rats were divided into control, ISO-treated, ISO+SO(2), and SO(2) groups. At the termination of the experiment, parameters of cardiac function and hemodynamics were measured and the micro-and ultrastructure of myocardium and stereological ultrastructure of mitochondria were analyzed. Myocardial SO(2) content was detected by high-performance liquid chromatography. GOT (key enzyme for endogenous SO(2) production) activity and gene (GOT1 and GOT2) expressions were measured, and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), hydrogen peroxide, and superoxide radical levels were assayed. SOD (SOD1 and SOD2) and GSH-Px (GSH-Px1) gene expressions were also detected. The results showed that SO(2) donor at a dose of 85 mg/(kg day) did not impact the cardiac function and structure of rats, but exerted a subtle influence on myocardial redox status. ISO-treated rats exhibited decreased cardiac function, damaged myocardial structures, and downregulated endogenous SO(2)/GOT pathway. Meanwhile, myocardial oxidative stress increased, whereas antioxidative capacity downregulated. Administration of SO(2) markedly improved cardiac function and ISO-induced myocardial damage by ameliorating the pathological structure of the myocardium and the mitochondria. At the same time, myocardial products of oxidative stress decreased, whereas antioxidative capacity increased. These results suggest that downregulation of the endogenous SO(2)/GOT pathway is likely involved in the pathogenesis of ISO-induced myocardial injury. SO(2) protects against ISO-induced myocardial injury associated with increased myocardial antioxidant capacity in rats. Laboratory Investigation (2011) 91, 12-23; doi:10.1038/labinvest.2010.156; published online 23 August 2010

语种英语
所属项目编号30630031 ; 30821001 ; 30801251 ; 307001 ; 2006CB503807
资助者National Natural Science Foundation of China ; Ministry of Education, China ; Major Basic Research Program of China ; National Natural Science Foundation of China ; Ministry of Education, China ; Major Basic Research Program of China
WOS记录号WOS:000285694600002
引用统计
被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53653
专题北京大学第一临床医学院_儿科
作者单位1.Minist Educ, Key Lab Mol Cardiovasc Dis, Beijing, Peoples R China
2.Northwestern Univ, Chicago, IL 60611 USA
3.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100034, Peoples R China
5.Univ Calif San Diego, Dept Biochem & Cell Biol, La Jolla, CA 92093 USA
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GB/T 7714
Liang, Yinfang,Liu, Die,Ochs, Todd,et al. Endogenous sulfur dioxide protects against isoproterenol-induced myocardial injury and increases myocardial antioxidant capacity in rats[J]. LABORATORY INVESTIGATION,2011,91(1):12-23.
APA Liang, Yinfang.,Liu, Die.,Ochs, Todd.,Tang, Chaoshu.,Chen, Stella.,...&Du, Junbao.(2011).Endogenous sulfur dioxide protects against isoproterenol-induced myocardial injury and increases myocardial antioxidant capacity in rats.LABORATORY INVESTIGATION,91(1),12-23.
MLA Liang, Yinfang,et al."Endogenous sulfur dioxide protects against isoproterenol-induced myocardial injury and increases myocardial antioxidant capacity in rats".LABORATORY INVESTIGATION 91.1(2011):12-23.
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