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学科主题: 临床医学
题名:
A Replication Study from Chinese Supports Association between Lupus-Risk Allele in TNFSF4 and Renal Disorder
作者: Zhou, Xu-jie; Cheng, Fa-juan; Qi, Yuan-yuan; Zhao, Ming-hui; Zhang, Hong1
刊名: BIOMED RESEARCH INTERNATIONAL
发表日期: 2013
DOI: 10.1155/2013/597921
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]: Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]: OX40 LIGAND ; ERYTHEMATOSUS ; GENE ; NEPHRITIS ; SUSCEPTIBILITY ; SNP
英文摘要:

A recent phenotypic association study of genetic susceptibility loci in SLE suggested that TNFSF4 gene might be useful to predict renal disorder in lupus patients. To replicate the association, two single-nucleotide polymorphisms (SNPs: rs2205960 and rs10489265) were genotyped in 814 SLE patients. Correlations between genotypes and TNFSF4 expression were determined. The stainings of TNFSF4 in renal biopsy specimens were checked by immunohistochemistry. The SNPs of TNFSF4 were associated with renal involvement in lupus patients from the Chinese population (P values for rs2205960 and rs10489265 were 0.014 and 0.005 in additive model, resp.). An association between risk genotypes and low C3 levels was also observed (P = 0.034). Functional prediction suggested that rs2205960 had a regulatory feature. The risk alleles seemingly correlated with lower TNFSF4 expression. Strong TNFSF4 expression was detected in lymph nodes and "apparently normal" paratumor renal biopsy but not in renal biopsies from lupus nephritis. In genome-wide expression data, TNFSF4 was also observed to be downregulated in LN in both glomeruli and tubulointerstitium from kidney biopsies. However, the associations were marginally significant. Our data firstly replicated the association of TNFSF4 with renal disorder in SLE patients in the Chinese population, which supported that TNFSF4 may act as a marker of lupus nephritis. The detailed mechanisms of its role in pathogenesis will still be further needed.

语种: 英语
所属项目编号: 2012CB517700 ; 81200524 ; 20121000110 ; 20120001120008 ; 81021004
项目资助者: Major State Basic Research Development Program of China (973 Program) ; National Natural Science Foundation of China ; Research Fund of Beijing Municipal Science and Technology for the Outstanding PhD Program ; Foundation of the Ministry of Education of China ; Natural Science Fund of China to the Innovation Research Group
WOS记录号: WOS:000321860100001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53655
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Inst Nephrol, Hosp 1, Key Lab Renal Dis,Minist Hlth China,Renal Div, Beijing 100034, Peoples R China
2.Peking Univ, Minist Educ, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing 100034, Peoples R China

Recommended Citation:
Zhou, Xu-jie,Cheng, Fa-juan,Qi, Yuan-yuan,et al. A Replication Study from Chinese Supports Association between Lupus-Risk Allele in TNFSF4 and Renal Disorder[J]. BIOMED RESEARCH INTERNATIONAL,2013.
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