|Radiofrequency ablation of problematically located hepatocellular carcinoma: tailored approach|
|Chen, Min-Hua; Yang, Wei; Yan, Kun; Hou, Yi-Bin; Dai, Ying; Gao, Wen; Zhang, Hui; Wu, Wei|
|关键词||Radiofrequency Ablation Hepatocellular Carcinoma Survival Rate Complications Ultrasound|
|WOS标题词||Science & Technology|
|类目[WOS]||Gastroenterology & Hepatology ; Radiology, Nuclear Medicine & Medical Imaging|
|研究领域[WOS]||Gastroenterology & Hepatology ; Radiology, Nuclear Medicine & Medical Imaging|
|关键词[WOS]||HEPATIC-TUMORS ; LIVER-TUMORS ; RECURRENCE ; RESECTION ; COMPLICATIONS ; MALIGNANCIES ; STRATEGY ; SAFETY ; RISK|
Aims: The challenge for radiofrequency ablation (RFA) of hepatocellular carcinomas (HCC) in problematic locations is that the outcome is limited due to insufficient ablation or injury of nearby structures. This study aimed to evaluate effective strategy and treatment results of RFA in these cases.
Methods: Ultrasound guided percutaneous RFA was performed in 326 HCC patients. Among them, 249 tumors in 215 patients located at liver periphery, including 54 adjacent to GI tract, 110 close to the diaphragm, 49 close to the gallbladder, and 36 tumors close to liver surface. The sizes of the tumors ranged 1.2-7.0 cm (average 3.7 +/- 1.3 cm). Individualized treatment strategy was established for tumors in various locations, including "artificial ascites", "lift-expand" electrode placement, "draw-expand" electrode placement, "Supplementary ablation", and "accumulative multiple ablations" techniques. Treatment outcome was compared with another 64 central-located tumors (control group) in the same patients. One-month post-RFA contrast CT was used to evaluate early necrosis rate of the treated tumors.
Results: Early tumor necrosis were obtained in 91.6% (228/249) of the problematically located HCC, including 90.7% (49/54) of the tumors adjacent to GI tract, 90.9% (100/110) near the diaphragm, 91.8% (45/49) by the gallbladder, and 94.4% (34/36) close to liver surface. The necrosis rate of control group was 98.4% (63/64), which was higher than the tumors close to diaphragm (P = 0.049). Local tumor recurrence was 8.4% (21/249), comparing with 3.1% (2/64) of the control group (P > 0.05). The 1-, 2- and 3-year survival rate of this group were 81.6%, 63.8%, and 53.6%, respectively. Major complications occurred in 3.2% (11/343) of the treatment sessions, including hemorrhage in two, nearby structure injury in five, and needle tract seeding in four patients.
Conclusions: Individualized treatment strategy for problematically located HCC is helpful in improving RFA outcome and expanding the application range of the therapy.
|作者单位||Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Ultrasound, Beijing 100036, Peoples R China|
|Chen, Min-Hua,Yang, Wei,Yan, Kun,et al. Radiofrequency ablation of problematically located hepatocellular carcinoma: tailored approach[J]. ABDOMINAL IMAGING,2008,33(4):428-436.|
|APA||Chen, Min-Hua.,Yang, Wei.,Yan, Kun.,Hou, Yi-Bin.,Dai, Ying.,...&Wu, Wei.(2008).Radiofrequency ablation of problematically located hepatocellular carcinoma: tailored approach.ABDOMINAL IMAGING,33(4),428-436.|
|MLA||Chen, Min-Hua,et al."Radiofrequency ablation of problematically located hepatocellular carcinoma: tailored approach".ABDOMINAL IMAGING 33.4(2008):428-436.|