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学科主题: 基础医学
题名:
Kindlin-2 inhibits serous epithelial ovarian cancer peritoneal dissemination and predicts patient outcomes
作者: Ren, Caixia1,2,3; Du, Juan1,2,3; Xi, Chenguang4; Yu, Yu1,2,3; Hu, Ajin4; Zhan, Jun1,2,3; Guo, Hongyan5; Fang, Weigang1,4; Liu, Congrong4; Zhang, Hongquan1,2,3
关键词: Serous epithelial ovarian cancer ; Kindlin-2 ; E-cadherin ; Estrogen receptor alpha
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2014-03-28
DOI: 10.1016/j.bbrc.2014.02.087
卷: 446, 期:1, 页:187-194
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: MITOGEN-INDUCIBLE GENE-2 ; ESTROGEN-RECEPTOR-ALPHA ; CELL ADHESION ; EXPRESSION ; INVASION ; ACTIVATION ; CARCINOMA ; ORIGINS ; ASCITES
英文摘要:

Kindlin-2 has been known to promote most cancer progression through regulation of multiple signaling pathways. However, a novel tumor suppressive role of Kindlin-2 was identified in serous epithelial ovarian cancer progression, which sharply contrasts to the tumor promoting roles for Kindlin-2 in most other cancers. While we demonstrated that Kindlin-2 was highly expressed in control tissues, a drastic low expression of Kindlin-2 was found in the tumor tissues of serous epithelial ovarian cancer, especially in the high-grade serous epithelial ovarian cancer. Importantly, Kindlin-2 inhibited serous epithelial ovarian cancer cell peritoneal dissemination in a mouse model. For clinical relevance, low Kindlin-2 expression correlated with higher tumor grade and older patients. Intriguingly, decreased Kindlin-2 expression predicts poor overall and progression-free survivals in serous epithelial ovarian cancer patients. Mechanistically, Kindlin-2 induced a mesenchymal to epithelial transition in serous epithelial ovarian cancer cells, at least in part, by up-regulation of estrogen receptor a which was recruited to the promoter of E-cadherin and thereby enhanced the transcription of E-cadherin. Collectively, we concluded that inadequate Kindlin-2 is an independent risk factor for serous epithelial ovarian cancer patients. (C) 2014 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2013CB910501 ; 2010CB912203 ; 2010CB529402 ; 2009CB521805 ; 30830048 ; 81230051 ; 31170711 ; 81101495 ; 7120002 ; BMU20120314
项目资助者: Ministry of Science and Technology of China ; National Natural Science Foundation of China ; 111 Project of the Ministry of Education ; Beijing Natural Science Foundation ; Peking University ; Beijing Education Bureau
WOS记录号: WOS:000334654900031
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53668
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Anat Histol & Embryol, Lab Mol Cell Biol & Tumor Biol, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
5.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100191, Peoples R China

Recommended Citation:
Ren, Caixia,Du, Juan,Xi, Chenguang,et al. Kindlin-2 inhibits serous epithelial ovarian cancer peritoneal dissemination and predicts patient outcomes[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2014,446(1):187-194.
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