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学科主题: 基础医学
题名:
The tumor suppressor p33(ING1b) upregulates p16(INK4a) expression and induces cellular senescence
作者: Li, Na; Li, Qian; Cao, Xiaoxiao; Zhao, Ganye; Xue, Lixiang; Tong, Tanjun
关键词: p33(ING1b) ; p16(INK4a) ; HAT ; Cellular senescence
刊名: FEBS LETTERS
发表日期: 2011-10-03
DOI: 10.1016/j.febslet.2011.08.044
卷: 585, 期:19, 页:3106-3112
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]: HUMAN-DIPLOID FIBROBLASTS ; ALTERNATIVE TRANSCRIPTS ; PROTEINS ; ING1 ; PROLIFERATION ; ACETYLATION ; INHIBITION ; REPRESSES ; APOPTOSIS ; COMPLEX
英文摘要:

ING1 protein is a tumor suppressor which plays significant roles in multiple cellular activities. p47(ING1a) and p33(ING1b) are major splice isoforms of ING1 and their roles in senescence need further investigations. Here we studied the functions of ING1 isoforms in cellular senescence and gene regulation, with focus on p16(INK4a). We observe that p33(ING1b) protein is the major ING1 isoform expressed in 2BS human diploid fibroblasts. Overexpression of p33(ING1b) induces cellular senescence and upregulates p16(INK4a) expression in 2BS fibroblasts. p33(ING1)b upregulates p16(INK4a) transcription. p33(ING1b) and p300 bind to the p16(INK4a) promoter. p300/CBP-specific inhibitor curcumin can reverse the induction of p16(INK4a) by p33(ING1b). These results help to better understand the function of ING1. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

语种: 英语
所属项目编号: 2007CB507400
项目资助者: National Basic Research Programs of China
WOS记录号: WOS:000295473600029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53669
Appears in Collections:基础医学院_北京大学衰老研究中心_期刊论文

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作者单位: Peking Univ, Res Ctr Aging, Dept Biochem & Mol Biol, Hlth Sci Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Li, Na,Li, Qian,Cao, Xiaoxiao,et al. The tumor suppressor p33(ING1b) upregulates p16(INK4a) expression and induces cellular senescence[J]. FEBS LETTERS,2011,585(19):3106-3112.
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