学科主题基础医学
The tumor suppressor p33(ING1b) upregulates p16(INK4a) expression and induces cellular senescence
Li, Na; Li, Qian; Cao, Xiaoxiao; Zhao, Ganye; Xue, Lixiang; Tong, Tanjun
关键词P33(Ing1b) P16(Ink4a) Hat Cellular Senescence
刊名FEBS LETTERS
2011-10-03
DOI10.1016/j.febslet.2011.08.044
585期:19页:3106-3112
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]HUMAN-DIPLOID FIBROBLASTS ; ALTERNATIVE TRANSCRIPTS ; PROTEINS ; ING1 ; PROLIFERATION ; ACETYLATION ; INHIBITION ; REPRESSES ; APOPTOSIS ; COMPLEX
英文摘要

ING1 protein is a tumor suppressor which plays significant roles in multiple cellular activities. p47(ING1a) and p33(ING1b) are major splice isoforms of ING1 and their roles in senescence need further investigations. Here we studied the functions of ING1 isoforms in cellular senescence and gene regulation, with focus on p16(INK4a). We observe that p33(ING1b) protein is the major ING1 isoform expressed in 2BS human diploid fibroblasts. Overexpression of p33(ING1b) induces cellular senescence and upregulates p16(INK4a) expression in 2BS fibroblasts. p33(ING1)b upregulates p16(INK4a) transcription. p33(ING1b) and p300 bind to the p16(INK4a) promoter. p300/CBP-specific inhibitor curcumin can reverse the induction of p16(INK4a) by p33(ING1b). These results help to better understand the function of ING1. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

语种英语
WOS记录号WOS:000295473600029
项目编号2007CB507400
资助机构National Basic Research Programs of China
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53669
专题北京大学基础医学院_北京大学衰老研究中心
北京大学基础医学院
作者单位Peking Univ, Res Ctr Aging, Dept Biochem & Mol Biol, Hlth Sci Ctr, Beijing 100191, Peoples R China
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GB/T 7714
Li, Na,Li, Qian,Cao, Xiaoxiao,et al. The tumor suppressor p33(ING1b) upregulates p16(INK4a) expression and induces cellular senescence[J]. FEBS LETTERS,2011,585(19):3106-3112.
APA Li, Na,Li, Qian,Cao, Xiaoxiao,Zhao, Ganye,Xue, Lixiang,&Tong, Tanjun.(2011).The tumor suppressor p33(ING1b) upregulates p16(INK4a) expression and induces cellular senescence.FEBS LETTERS,585(19),3106-3112.
MLA Li, Na,et al."The tumor suppressor p33(ING1b) upregulates p16(INK4a) expression and induces cellular senescence".FEBS LETTERS 585.19(2011):3106-3112.
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