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C3-Spacer-containing circular oligonucleotides as inhibitors of human topoisomerase I
Wang, Yifan1; Ng, Magdeline Tao Tao1; Zhou, Tianyan3; Li, Xinming1; Tan, Choon Hong1; Li, Tianhu1,2
关键词Circular Oligonucleotide Human Topoisomerase i Enzyme Inhibitor
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2008-06-15
DOI10.1016/j.bmcl.2008.04.076
18期:12页:3597-3602
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]RNA/DNA CHIMERIC OLIGONUCLEOTIDES ; EUKARYOTIC TOPOISOMERASE ; GENE-EXPRESSION ; DNA INTERACTION ; CLEAVAGE ; RELAXATION ; ROLES ; MODE
英文摘要

Some dumbbell-shaped circular oligonucleotides containing internal C3-spacers and Topo I-binding sites were designed and synthesized which displayed high inhibitory efficiency on the activity of human Topo I as well as resisted the degradation by some DNA repair enzymes. (C) 2008 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000256495500029
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53671
专题北京大学药学院_药剂学系
作者单位1.Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore
2.Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637616, Singapore
3.Peking Univ, Sch Pharm, Dept Pharmaceut, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Wang, Yifan,Ng, Magdeline Tao Tao,Zhou, Tianyan,et al. C3-Spacer-containing circular oligonucleotides as inhibitors of human topoisomerase I[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2008,18(12):3597-3602.
APA Wang, Yifan,Ng, Magdeline Tao Tao,Zhou, Tianyan,Li, Xinming,Tan, Choon Hong,&Li, Tianhu.(2008).C3-Spacer-containing circular oligonucleotides as inhibitors of human topoisomerase I.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,18(12),3597-3602.
MLA Wang, Yifan,et al."C3-Spacer-containing circular oligonucleotides as inhibitors of human topoisomerase I".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 18.12(2008):3597-3602.
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