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学科主题: 药学
题名:
C3-Spacer-containing circular oligonucleotides as inhibitors of human topoisomerase I
作者: Wang, Yifan1; Ng, Magdeline Tao Tao1; Zhou, Tianyan3; Li, Xinming1; Tan, Choon Hong1; Li, Tianhu1,2
关键词: circular oligonucleotide ; human topoisomerase I ; enzyme inhibitor
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
发表日期: 2008-06-15
DOI: 10.1016/j.bmcl.2008.04.076
卷: 18, 期:12, 页:3597-3602
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: RNA/DNA CHIMERIC OLIGONUCLEOTIDES ; EUKARYOTIC TOPOISOMERASE ; GENE-EXPRESSION ; DNA INTERACTION ; CLEAVAGE ; RELAXATION ; ROLES ; MODE
英文摘要:

Some dumbbell-shaped circular oligonucleotides containing internal C3-spacers and Topo I-binding sites were designed and synthesized which displayed high inhibitory efficiency on the activity of human Topo I as well as resisted the degradation by some DNA repair enzymes. (C) 2008 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000256495500029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53671
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore
2.Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637616, Singapore
3.Peking Univ, Sch Pharm, Dept Pharmaceut, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Yifan,Ng, Magdeline Tao Tao,Zhou, Tianyan,et al. C3-Spacer-containing circular oligonucleotides as inhibitors of human topoisomerase I[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2008,18(12):3597-3602.
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