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学科主题临床医学
Octreotide decreases portal pressure: Hepatic stellate cells may play a pivotal role
Zhai, Yun2; Zhang, Juan2,5; Shang, Hong-wei4; Lu, Shi-chun3; Wang, Meng-long3; You, Hong1; Jia, Ji-dong1; Dinga, Hui-guo1
关键词Hepatic Stellate Cell Somatostatin Receptor Subtype Octreotide Portal Hypertension Liver Cirrhosis
刊名AFRICAN JOURNAL OF BIOTECHNOLOGY
2010-03-22
9期:12页:1833-1838
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology
资助者New Star Plan of Science and Technology of Beijing ; Beijing Natural Science Foundation ; State Natural Science Foundation ; New Star Plan of Science and Technology of Beijing ; Beijing Natural Science Foundation ; State Natural Science Foundation
研究领域[WOS]Biotechnology & Applied Microbiology
关键词[WOS]HYPERTENSION ; SOMATOSTATIN ; COMPLICATIONS ; PREVENTION ; EXPRESSION ; LIVER
英文摘要

The aim of this study is to elucidate the effects of different dosages of octreotide on portal pressure in cirrhotic patients and to investigate the mechanism of activated human hepatic stellate cells (HSCs) on octreotide. Thirty-one (31) hepatitis B-related cirrhotic patients were randomly assigned to receive treatment with a 50 (group A, n = 12) or a 25 mu g/h infusion of octreotide for 72 h (group B, n = 14); the control group C (n = 5) received conventional treatment. Dynamic portal pressure was directly measured via a portal vein catheter. To study the cellular mechanism of octreotide, the expression of SSTRs 1-5 in LX-2, an HSC line, was examined by immunostaining and RT-PCR. Intracellular Ca(2+) in LX2 was measured by laser scanning confocal microscopy (LSCM). The protein and mRNA levels in all five subtypes of SSTRs were positively expressed in LX-2. Octreotide led to an immediate two-fold drop in intracellular Ca(2+) (P < 0.01). Portal pressure, in both groups A and B, decreased significantly (mean, -20.6%) after octreotide infusion. Octreotide decreased portal pressure in cirrhotic patients by inhibiting HSC contractility by decreasing intracellular Ca(2+) concentration via stimulation of all SSTRs on HSCs.

语种英语
所属项目编号954812500 ; 7062032 ; 30872225
资助者New Star Plan of Science and Technology of Beijing ; Beijing Natural Science Foundation ; State Natural Science Foundation ; New Star Plan of Science and Technology of Beijing ; Beijing Natural Science Foundation ; State Natural Science Foundation
WOS记录号WOS:000276326600018
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53673
专题北京大学首钢医院_消化科
作者单位1.Capital Med Univ, Beijing Friendship Hosp, Liver Dis Ctr, Beijing 100069, Peoples R China
2.Capital Med Univ, Beijing Youan Hosp, Dept Gastroenterol & Hepatol, Beijing 100069, Peoples R China
3.Capital Med Univ, Beijing Youan Hosp, Dept Surg, Beijing 100069, Peoples R China
4.Capital Med Univ, Lab Ctr, Beijing 100069, Peoples R China
5.Peking Univ, Shougang Hosp, Dept Gastroenterol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhai, Yun,Zhang, Juan,Shang, Hong-wei,et al. Octreotide decreases portal pressure: Hepatic stellate cells may play a pivotal role[J]. AFRICAN JOURNAL OF BIOTECHNOLOGY,2010,9(12):1833-1838.
APA Zhai, Yun.,Zhang, Juan.,Shang, Hong-wei.,Lu, Shi-chun.,Wang, Meng-long.,...&Dinga, Hui-guo.(2010).Octreotide decreases portal pressure: Hepatic stellate cells may play a pivotal role.AFRICAN JOURNAL OF BIOTECHNOLOGY,9(12),1833-1838.
MLA Zhai, Yun,et al."Octreotide decreases portal pressure: Hepatic stellate cells may play a pivotal role".AFRICAN JOURNAL OF BIOTECHNOLOGY 9.12(2010):1833-1838.
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