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学科主题: 临床医学
题名:
Octreotide decreases portal pressure: Hepatic stellate cells may play a pivotal role
作者: Zhai, Yun2; Zhang, Juan2,5; Shang, Hong-wei4; Lu, Shi-chun3; Wang, Meng-long3; You, Hong1; Jia, Ji-dong1; Dinga, Hui-guo1
关键词: Hepatic stellate cell ; somatostatin receptor subtype ; octreotide ; portal hypertension ; liver cirrhosis
刊名: AFRICAN JOURNAL OF BIOTECHNOLOGY
发表日期: 2010-03-22
卷: 9, 期:12, 页:1833-1838
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology
研究领域[WOS]: Biotechnology & Applied Microbiology
关键词[WOS]: HYPERTENSION ; SOMATOSTATIN ; COMPLICATIONS ; PREVENTION ; EXPRESSION ; LIVER
英文摘要:

The aim of this study is to elucidate the effects of different dosages of octreotide on portal pressure in cirrhotic patients and to investigate the mechanism of activated human hepatic stellate cells (HSCs) on octreotide. Thirty-one (31) hepatitis B-related cirrhotic patients were randomly assigned to receive treatment with a 50 (group A, n = 12) or a 25 mu g/h infusion of octreotide for 72 h (group B, n = 14); the control group C (n = 5) received conventional treatment. Dynamic portal pressure was directly measured via a portal vein catheter. To study the cellular mechanism of octreotide, the expression of SSTRs 1-5 in LX-2, an HSC line, was examined by immunostaining and RT-PCR. Intracellular Ca(2+) in LX2 was measured by laser scanning confocal microscopy (LSCM). The protein and mRNA levels in all five subtypes of SSTRs were positively expressed in LX-2. Octreotide led to an immediate two-fold drop in intracellular Ca(2+) (P < 0.01). Portal pressure, in both groups A and B, decreased significantly (mean, -20.6%) after octreotide infusion. Octreotide decreased portal pressure in cirrhotic patients by inhibiting HSC contractility by decreasing intracellular Ca(2+) concentration via stimulation of all SSTRs on HSCs.

语种: 英语
所属项目编号: 954812500 ; 7062032 ; 30872225
项目资助者: New Star Plan of Science and Technology of Beijing ; Beijing Natural Science Foundation ; State Natural Science Foundation
WOS记录号: WOS:000276326600018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53673
Appears in Collections:北京大学首钢医院_消化科_期刊论文

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作者单位: 1.Capital Med Univ, Beijing Friendship Hosp, Liver Dis Ctr, Beijing 100069, Peoples R China
2.Capital Med Univ, Beijing Youan Hosp, Dept Gastroenterol & Hepatol, Beijing 100069, Peoples R China
3.Capital Med Univ, Beijing Youan Hosp, Dept Surg, Beijing 100069, Peoples R China
4.Capital Med Univ, Lab Ctr, Beijing 100069, Peoples R China
5.Peking Univ, Shougang Hosp, Dept Gastroenterol, Beijing 100871, Peoples R China

Recommended Citation:
Zhai, Yun,Zhang, Juan,Shang, Hong-wei,et al. Octreotide decreases portal pressure: Hepatic stellate cells may play a pivotal role[J]. AFRICAN JOURNAL OF BIOTECHNOLOGY,2010,9(12):1833-1838.
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