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学科主题: 药学
题名:
Brain-derived neurotrophic factor protects neurons from GdCl3-induced impairment in neuron-astrocyte co-cultures
作者: Xia Qing1; Feng XuDong; Yuan Lan; Wang Kui; Yang XiaoDa
关键词: gadolinium ; brain-derived neurotrophic factor ; BDNF ; co-culture ; astrocytes ; neurons
刊名: SCIENCE CHINA-CHEMISTRY
发表日期: 2010-10-01
DOI: 10.1007/s11426-010-4105-x
卷: 53, 期:10, 页:2193-2199
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: OXIDATIVE STRESS ; CORTICAL-NEURONS ; IN-VIVO ; BDNF ; NEUROTOXICITY ; RATS ; CYTOTOXICITY ; EXPRESSION ; INJECTION ; GROWTH
英文摘要:

Gadolinium (Gd3+) complexes are important contrast agents in medical magnetic resonance imaging (MRI) and of great potential value in brain research. In order to better understand the mechanisms of the action of Gd3+ on neurons in the complex central nervous system (CNS), the neurotoxic actions of GdCl3 have been investigated in both neuron monoculture and astrocyte neuron co-culture systems. Measurements of lactate dehydrogenase release showed that GdCl3 causes significant cell death of monocultured neurons as a result of reactive oxygen species (ROS) generation and down-regulation of brain-derived neurotrophic factor (BDNF). However, GdCl3 does not affect the viability and BDNF expression of astrocytes. Both co-culturing of neurons with astrocytes and addition of BDNF ameliorated GdCl3-induced neurotoxicity by decreasing ROS generation and facilitating recovery of BDNF levels. The results obtained suggest that astrocytes in the CNS may protect neurons from GdCl3-induced impairment through secreting BDNF and thus up-regulating BDNF expression and interfering with Gd3+-induced cell signaling in neurons. A possible molecular mechanism is suggested which should be helpful in understanding the neurotoxic actions of gadolinium probes.

语种: 英语
所属项目编号: 20901005 ; 20637010 ; 200800011056
项目资助者: National Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education
WOS记录号: WOS:000283396200019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53681
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China

Recommended Citation:
Xia Qing,Feng XuDong,Yuan Lan,et al. Brain-derived neurotrophic factor protects neurons from GdCl3-induced impairment in neuron-astrocyte co-cultures[J]. SCIENCE CHINA-CHEMISTRY,2010,53(10):2193-2199.
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