IR@PKUHSC  > 北京大学药学院
学科主题药学
Brain-derived neurotrophic factor protects neurons from GdCl3-induced impairment in neuron-astrocyte co-cultures
Xia Qing1; Feng XuDong; Yuan Lan; Wang Kui; Yang XiaoDa
关键词Gadolinium Brain-derived Neurotrophic Factor Bdnf Co-culture Astrocytes Neurons
刊名SCIENCE CHINA-CHEMISTRY
2010-10-01
DOI10.1007/s11426-010-4105-x
53期:10页:2193-2199
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
资助者National Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education ; National Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education
研究领域[WOS]Chemistry
关键词[WOS]OXIDATIVE STRESS ; CORTICAL-NEURONS ; IN-VIVO ; BDNF ; NEUROTOXICITY ; RATS ; CYTOTOXICITY ; EXPRESSION ; INJECTION ; GROWTH
英文摘要

Gadolinium (Gd3+) complexes are important contrast agents in medical magnetic resonance imaging (MRI) and of great potential value in brain research. In order to better understand the mechanisms of the action of Gd3+ on neurons in the complex central nervous system (CNS), the neurotoxic actions of GdCl3 have been investigated in both neuron monoculture and astrocyte neuron co-culture systems. Measurements of lactate dehydrogenase release showed that GdCl3 causes significant cell death of monocultured neurons as a result of reactive oxygen species (ROS) generation and down-regulation of brain-derived neurotrophic factor (BDNF). However, GdCl3 does not affect the viability and BDNF expression of astrocytes. Both co-culturing of neurons with astrocytes and addition of BDNF ameliorated GdCl3-induced neurotoxicity by decreasing ROS generation and facilitating recovery of BDNF levels. The results obtained suggest that astrocytes in the CNS may protect neurons from GdCl3-induced impairment through secreting BDNF and thus up-regulating BDNF expression and interfering with Gd3+-induced cell signaling in neurons. A possible molecular mechanism is suggested which should be helpful in understanding the neurotoxic actions of gadolinium probes.

语种英语
所属项目编号20901005 ; 20637010 ; 200800011056
资助者National Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education ; National Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education
WOS记录号WOS:000283396200019
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53681
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Xia Qing,Feng XuDong,Yuan Lan,et al. Brain-derived neurotrophic factor protects neurons from GdCl3-induced impairment in neuron-astrocyte co-cultures[J]. SCIENCE CHINA-CHEMISTRY,2010,53(10):2193-2199.
APA Xia Qing,Feng XuDong,Yuan Lan,Wang Kui,&Yang XiaoDa.(2010).Brain-derived neurotrophic factor protects neurons from GdCl3-induced impairment in neuron-astrocyte co-cultures.SCIENCE CHINA-CHEMISTRY,53(10),2193-2199.
MLA Xia Qing,et al."Brain-derived neurotrophic factor protects neurons from GdCl3-induced impairment in neuron-astrocyte co-cultures".SCIENCE CHINA-CHEMISTRY 53.10(2010):2193-2199.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Xia Qing]的文章
[Feng XuDong]的文章
[Yuan Lan]的文章
百度学术
百度学术中相似的文章
[Xia Qing]的文章
[Feng XuDong]的文章
[Yuan Lan]的文章
必应学术
必应学术中相似的文章
[Xia Qing]的文章
[Feng XuDong]的文章
[Yuan Lan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。