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学科主题临床医学
Genetic polymorphisms of GSTT1, GSTM1, and NQO1 genes and diabetes mellitus risk in Chinese population
Wang, GY; Zhang, L; Li, QF
关键词Diabetes Mellitus Type 2 Gene Gstm1 Gstt1 Nqo1 Polymorphism
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2006-03-10
DOI10.1016/j.bbrc.2005.12.195
341期:2页:310-313
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]DT-DIAPHORASE ; BETA-CELLS
英文摘要

Objective: The aims of the present study were to assess whether the glutathione S-transferase T1 (GSTT1), M1 (GSTM1), and NAD(P)H: quinone oxidoreductase 1 (NQO1) genotypes are associated with type 2 diabetes mellitus (T2 DM) and to ascertain whether the levels of blood lipids given exposure to diabetes are modified by the specific genetic polymorphisms of GSTT1, GSTM1, and NQO1.

Methods: This case-control study was conducted on 200 subjects. The genotypes were determined using a polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism.

Results: The GSTT1-present genotype conferred a statistically significant 0.49-fold reduction in risk of T2 DM relative to the null genotype. Individuals with GSTT1-null or GSTMI-null genotype had higher levels of low-density-lipoprotein cholesterol, apolipoprotein B, and lipoprotein(a), respectively. There was no association between either GSTM1 or NQO1 polymorphism and risk of T2 DM.

Conclusion: The present results Suggest that the GSTTI gene may contribute to the development of T2 DM and may be one of the candidate genes of T2 DM in Chinese population. (c) 2006 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000235414400006
引用统计
被引频次:49[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53686
专题北京大学第三临床医学院_内分泌科
作者单位Peking Univ, Dept Endocrinol, Hosp 3, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Wang, GY,Zhang, L,Li, QF. Genetic polymorphisms of GSTT1, GSTM1, and NQO1 genes and diabetes mellitus risk in Chinese population[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,341(2):310-313.
APA Wang, GY,Zhang, L,&Li, QF.(2006).Genetic polymorphisms of GSTT1, GSTM1, and NQO1 genes and diabetes mellitus risk in Chinese population.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,341(2),310-313.
MLA Wang, GY,et al."Genetic polymorphisms of GSTT1, GSTM1, and NQO1 genes and diabetes mellitus risk in Chinese population".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 341.2(2006):310-313.
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