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IR@PKUHSC  > 北京大学第三临床医学院  > 内分泌科  > 期刊论文
学科主题: 临床医学
题名:
Genetic polymorphisms of GSTT1, GSTM1, and NQO1 genes and diabetes mellitus risk in Chinese population
作者: Wang, GY; Zhang, L; Li, QF
关键词: diabetes mellitus type 2 ; gene ; GSTM1 ; GSTT1 ; NQO1 ; polymorphism
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2006-03-10
DOI: 10.1016/j.bbrc.2005.12.195
卷: 341, 期:2, 页:310-313
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: DT-DIAPHORASE ; BETA-CELLS
英文摘要:

Objective: The aims of the present study were to assess whether the glutathione S-transferase T1 (GSTT1), M1 (GSTM1), and NAD(P)H: quinone oxidoreductase 1 (NQO1) genotypes are associated with type 2 diabetes mellitus (T2 DM) and to ascertain whether the levels of blood lipids given exposure to diabetes are modified by the specific genetic polymorphisms of GSTT1, GSTM1, and NQO1.

Methods: This case-control study was conducted on 200 subjects. The genotypes were determined using a polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism.

Results: The GSTT1-present genotype conferred a statistically significant 0.49-fold reduction in risk of T2 DM relative to the null genotype. Individuals with GSTT1-null or GSTMI-null genotype had higher levels of low-density-lipoprotein cholesterol, apolipoprotein B, and lipoprotein(a), respectively. There was no association between either GSTM1 or NQO1 polymorphism and risk of T2 DM.

Conclusion: The present results Suggest that the GSTTI gene may contribute to the development of T2 DM and may be one of the candidate genes of T2 DM in Chinese population. (c) 2006 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000235414400006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53686
Appears in Collections:北京大学第三临床医学院_内分泌科_期刊论文

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作者单位: Peking Univ, Dept Endocrinol, Hosp 3, Beijing 100083, Peoples R China

Recommended Citation:
Wang, GY,Zhang, L,Li, QF. Genetic polymorphisms of GSTT1, GSTM1, and NQO1 genes and diabetes mellitus risk in Chinese population[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,341(2):310-313.
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