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Lower serum cytokine levels in smokers than nonsmokers with chronic schizophrenia on long-term treatment with antipsychotics
Zhang, Xiang Yang1,2; Cao, Lian Yuan2; Song, Cai3,4; Wu, Gui Ying1; Chen, Da Chun2; Qi, Ling Yan2; Wang, Fan2; Xiu, Mei Hong2; Chen, Song2; Zhang, Yingyang1,2; Lu, Lin5; Kosten, Therese A.1; Kosten, Thomas R.1
关键词Schizophrenia Smoking Nicotine Cytokine Immune
刊名PSYCHOPHARMACOLOGY
2008-12-01
DOI10.1007/s00213-008-1295-4
201期:3页:383-389
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]NICOTINE DEPENDENCE ; CIGARETTE-SMOKING ; NEUROLEPTIC TREATMENT ; INTERLEUKIN-2 ; PSYCHOPATHOLOGY ; ASSOCIATION ; RECEPTORS ; IL-2 ; RESISTANT ; CELLS
英文摘要

Schizophrenia is associated with various abnormalities in the immune system. Suppression of inflammatory cytokines by cigarette smoke is well-established. The purpose of this study was to determine any differences in cytokine profiles in smokers and nonsmokers with schizophrenia and whether there were any relationships among altered cytokine profiles and psychopathological symptoms.

Serum interleukin (IL)-2, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha levels were measured in 96 male inpatients with DSM-IV schizophrenia: 66 smokers and 30 nonsmokers. Symptoms were assessed with the Positive and Negative Syndrome Scale (PANSS).

The positive PANSS symptoms were lower in smokers than nonsmokers, while the negative symptoms were lower in those who smoked more cigarettes. Cytokine levels were positively correlated: IL-2 level with IL-6 and IL-6 with both IL-8 and TNF-alpha. Both IL-2 and IL-6, but not IL-8 or TNF-alpha, were significantly lower in smokers than nonsmokers (p < 0.002; p < 0.01). Lower IL-2 levels correlated with fewer negative symptoms and with smoking more cigarettes.

The fewer positive symptoms in smokers and fewer negative symptoms in those who smoked more cigarettes may be associated with nicotine-induced suppression of some inflammatory cytokines.

语种英语
WOS记录号WOS:000261037300007
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53689
专题中国药物依赖性研究所
作者单位1.NRC Inst Nutrisci & Hlth, Charlottetown, PE, Canada
2.Beijing Hui Long Guan Hosp, Ctr Biol Psychiat, Beijing, Peoples R China
3.Baylor Coll Med, VA Med Ctr, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA
4.Univ Prince Edward Isl, Atlantic Vet Coll, Dept Biomed Sci, Charlottetown, PE C1A 4P3, Canada
5.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Xiang Yang,Cao, Lian Yuan,Song, Cai,et al. Lower serum cytokine levels in smokers than nonsmokers with chronic schizophrenia on long-term treatment with antipsychotics[J]. PSYCHOPHARMACOLOGY,2008,201(3):383-389.
APA Zhang, Xiang Yang.,Cao, Lian Yuan.,Song, Cai.,Wu, Gui Ying.,Chen, Da Chun.,...&Kosten, Thomas R..(2008).Lower serum cytokine levels in smokers than nonsmokers with chronic schizophrenia on long-term treatment with antipsychotics.PSYCHOPHARMACOLOGY,201(3),383-389.
MLA Zhang, Xiang Yang,et al."Lower serum cytokine levels in smokers than nonsmokers with chronic schizophrenia on long-term treatment with antipsychotics".PSYCHOPHARMACOLOGY 201.3(2008):383-389.
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