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学科主题: 药物依赖
题名:
Lower serum cytokine levels in smokers than nonsmokers with chronic schizophrenia on long-term treatment with antipsychotics
作者: Zhang, Xiang Yang1,2; Cao, Lian Yuan2; Song, Cai3,4; Wu, Gui Ying1; Chen, Da Chun2; Qi, Ling Yan2; Wang, Fan2; Xiu, Mei Hong2; Chen, Song2; Zhang, Yingyang1,2; Lu, Lin5; Kosten, Therese A.1; Kosten, Thomas R.1
关键词: Schizophrenia ; Smoking ; Nicotine ; Cytokine ; Immune
刊名: PSYCHOPHARMACOLOGY
发表日期: 2008-12-01
DOI: 10.1007/s00213-008-1295-4
卷: 201, 期:3, 页:383-389
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: NICOTINE DEPENDENCE ; CIGARETTE-SMOKING ; NEUROLEPTIC TREATMENT ; INTERLEUKIN-2 ; PSYCHOPATHOLOGY ; ASSOCIATION ; RECEPTORS ; IL-2 ; RESISTANT ; CELLS
英文摘要:

Schizophrenia is associated with various abnormalities in the immune system. Suppression of inflammatory cytokines by cigarette smoke is well-established. The purpose of this study was to determine any differences in cytokine profiles in smokers and nonsmokers with schizophrenia and whether there were any relationships among altered cytokine profiles and psychopathological symptoms.

Serum interleukin (IL)-2, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha levels were measured in 96 male inpatients with DSM-IV schizophrenia: 66 smokers and 30 nonsmokers. Symptoms were assessed with the Positive and Negative Syndrome Scale (PANSS).

The positive PANSS symptoms were lower in smokers than nonsmokers, while the negative symptoms were lower in those who smoked more cigarettes. Cytokine levels were positively correlated: IL-2 level with IL-6 and IL-6 with both IL-8 and TNF-alpha. Both IL-2 and IL-6, but not IL-8 or TNF-alpha, were significantly lower in smokers than nonsmokers (p < 0.002; p < 0.01). Lower IL-2 levels correlated with fewer negative symptoms and with smoking more cigarettes.

The fewer positive symptoms in smokers and fewer negative symptoms in those who smoked more cigarettes may be associated with nicotine-induced suppression of some inflammatory cytokines.

语种: 英语
WOS记录号: WOS:000261037300007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53689
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.NRC Inst Nutrisci & Hlth, Charlottetown, PE, Canada
2.Beijing Hui Long Guan Hosp, Ctr Biol Psychiat, Beijing, Peoples R China
3.Baylor Coll Med, VA Med Ctr, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA
4.Univ Prince Edward Isl, Atlantic Vet Coll, Dept Biomed Sci, Charlottetown, PE C1A 4P3, Canada
5.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Xiang Yang,Cao, Lian Yuan,Song, Cai,et al. Lower serum cytokine levels in smokers than nonsmokers with chronic schizophrenia on long-term treatment with antipsychotics[J]. PSYCHOPHARMACOLOGY,2008,201(3):383-389.
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