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学科主题基础医学
Response of human dendritic cells to different immunomodulatory polysaccharides derived from mushroom and barley
Chan, Wing Keung; Law, Helen Ka Wai; Lin, Zhi-Bin; Lau, Yu Lung; Chan, Godfrey Chi-Fung
关键词Barley Ganoderma Lucidum Human Dendritic Cell Immunomodulation Polysaccharides
刊名INTERNATIONAL IMMUNOLOGY
2007-07-01
DOI10.1093/intimm/dxm061
19期:7页:891-899
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]GANODERMA-LUCIDUM POLYSACCHARIDES ; MONOCLONAL-ANTIBODIES ; BETA-GLUCANS ; IMMUNITY ; ANTITUMOR ; DECTIN-1 ; IMMUNOTHERAPY ; MATURATION ; ADJUVANTS ; RECEPTOR
英文摘要

Polysaccharides derived from fungi and plants have been increasingly used as dietary supplement with therapeutic intention for cancer. However, whether these polysaccharides from different sources and structures can elicit similar immunological effects remain unknown. This study aims to investigate and compare the effects of selected groups of purified and crude polysaccharides on human dendritic cells (DCs), the most potent antigen-presenting cells. The selected polysaccharides were from Ganoderma lucidum [(GL) Lingzhi, Reishi], a medicinal mushroom commonly used by oriental; and barley glucan, a purified polysaccharide with known in vivo immunomodulating effect. We found that purified polysaccharides from GL mycelium could induce human PBMC proliferation and phenotypic and functional maturation of DCs with significant IL-12 and IL-10 production. Polysaccharides of GL spore and barley were both rather weak immunostimulator in vitro. In general, all these polysaccharides did not polarize T cells into either TO or TO or regulatory T cells, except for crude spore polysaccharides-treated DCs which could suppress T cell proliferation with IL-10 production. This study revealed the polysaccharides of different sources have different immune potency and effect on human immune cells including DCs. Our study also provides a reproducible biological platform for comparing the potential therapeutic effects of different herbal-derived polysaccharides in the future.

语种英语
WOS记录号WOS:000249127900008
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被引频次:51[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53693
专题北京大学基础医学院_药理学系
作者单位1.Univ Hong Kong, Queen Mary Hosp, Fac Med,Dept Paediat & Adolescent Med, Hong Kong Jockey Club Clin Res Ctr, Hong Kong, Hong Kong, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Pharmacol, Sch Basic Med Sci, Beijing 100871, Peoples R China
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Chan, Wing Keung,Law, Helen Ka Wai,Lin, Zhi-Bin,et al. Response of human dendritic cells to different immunomodulatory polysaccharides derived from mushroom and barley[J]. INTERNATIONAL IMMUNOLOGY,2007,19(7):891-899.
APA Chan, Wing Keung,Law, Helen Ka Wai,Lin, Zhi-Bin,Lau, Yu Lung,&Chan, Godfrey Chi-Fung.(2007).Response of human dendritic cells to different immunomodulatory polysaccharides derived from mushroom and barley.INTERNATIONAL IMMUNOLOGY,19(7),891-899.
MLA Chan, Wing Keung,et al."Response of human dendritic cells to different immunomodulatory polysaccharides derived from mushroom and barley".INTERNATIONAL IMMUNOLOGY 19.7(2007):891-899.
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