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学科主题: 临床医学
题名:
Predicting Hyperhomocysteinemia by Methylenetetrahydrofolate Reductase C677T Polymorphism in Chinese Patients With Hypertension
作者: Wang, Yu1; Xu, Xin1; Huo, Yong2,3; Liu, Dahai4,5; Cui, Yimin3,6; Liu, Zeyuan7; Zhao, Zhigang8; Xu, Xiping9; Liu, Lisheng10; Li, Xiaoying11; Jiang, Shanqun4,5,9
关键词: MTHFR ; polymorphism ; hyperhomocysteinemia ; prediction ; hypertension
刊名: CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
发表日期: 2015-10-01
DOI: 10.1177/1076029613519849
卷: 21, 期:7, 页:661-666
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: GENOME-WIDE ASSOCIATION ; PLASMA HOMOCYSTEINE CONCENTRATIONS ; CORONARY-ARTERY-DISEASE ; RISK-FACTOR ; VASCULAR-DISEASE ; CARDIOVASCULAR-DISEASE ; COMMON MUTATION ; BLOOD-PRESSURE ; FOLATE STATUS ; FOLIC-ACID
英文摘要:

Objective: To evaluate the performance of methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism in predicting hyperhomocysteinemia (HHcy) in Chinese patients with hypertension.

Methods: We measured plasma total homocysteine tHcy level and C677T genotype in 1058 Chinese patients with hypertension from 4 previous studies. We used 10, 15, and 20 mol/L as cutoff values for the definition of mild, modest, and severe HHcy, respectively. Logistic models for HHcy were built from the study sample using the C677T genotype as well as age and gender as predictors. The receiver-operating characteristics of the models were evaluated.

Results: Our major findings are that (1) C677T TT genotype is consistently associated with a higher tHcy across the 4 studies, with an increase in size ranging from 38% to 68% in the 4 studies and 51% overall. The C677T polymorphism independently explained about 14% of the total variance of the normalized tHcy. (2) The TT genotype is associated with a large increase in odds ratio (OR) for HHcy. Overall, the multivariate-adjusted ORs for the TT genotype are 3.9 (95% confidence interval [CI]: 2.4-6.4), 6.5 (95% CI: 4.0-10.6), and 17.9 (95% CI: 8.4-38.1) for mild, modest, and severe HHcy, respectively. (3) Overall, the predicting performance increased with HHcy severity, with sensitivity improving from 31.0% for mild HHcy to 70.3% for severe HHcy, and with specificity slightly decreasing from 85.4% to 80.3%. Inclusion of gender and age as predictors significantly improves the sensitivity, especially for predicting mild HHcy.

Conclusion: With an excellent sensitivity and a modest specificity, C677T could be a useful screening marker for severe HHcy.

语种: 英语
所属项目编号: 2012CB517703 ; 81373484 ; 81141116 ; 30700454
项目资助者: Major State Basic Research Development Program ; National Natural Science Foundation of China
WOS记录号: WOS:000360827200010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53694
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Dept Med, Beijing, Peoples R China
2.Anhui Univ, Sch Life Sci, Hefei 230061, Peoples R China
3.Peking Univ, Hosp 1, Dept Pharm, Beijing 100871, Peoples R China
4.Anhui Med Univ, Inst Biomed, Hefei, Peoples R China
5.Southern Med Univ, Nanfang Hosp, Div Nephrol, Guangzhou, Guangdong, Peoples R China
6.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China
7.Anhui Univ, Sch Life Sci, Ctr Stem Cell & Translat Med, Hefei 230061, Peoples R China
8.Acad Mil Med Sci, Affiliated Hosp, Dept Clin Pharmacol, Beijing, Peoples R China
9.Capital Med Univ, Beijing Tiantan Hosp, Dept Pharm, Beijing, Peoples R China
10.China Med Acad, Beijing Fuwai Hosp, Beijing, Peoples R China
11.Peoples Liberat Army Gen Hosp, Dept Geriatr Cardiol, Beijing, Peoples R China

Recommended Citation:
Wang, Yu,Xu, Xin,Huo, Yong,et al. Predicting Hyperhomocysteinemia by Methylenetetrahydrofolate Reductase C677T Polymorphism in Chinese Patients With Hypertension[J]. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS,2015,21(7):661-666.
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