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学科主题临床医学
Predicting Hyperhomocysteinemia by Methylenetetrahydrofolate Reductase C677T Polymorphism in Chinese Patients With Hypertension
Wang, Yu1; Xu, Xin1; Huo, Yong2,3; Liu, Dahai4,5; Cui, Yimin3,6; Liu, Zeyuan7; Zhao, Zhigang8; Xu, Xiping9; Liu, Lisheng10; Li, Xiaoying11; Jiang, Shanqun4,5,9
关键词Mthfr Polymorphism Hyperhomocysteinemia Prediction Hypertension
刊名CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
2015-10-01
DOI10.1177/1076029613519849
21期:7页:661-666
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
资助者Major State Basic Research Development Program ; National Natural Science Foundation of China ; Major State Basic Research Development Program ; National Natural Science Foundation of China
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]GENOME-WIDE ASSOCIATION ; PLASMA HOMOCYSTEINE CONCENTRATIONS ; CORONARY-ARTERY-DISEASE ; RISK-FACTOR ; VASCULAR-DISEASE ; CARDIOVASCULAR-DISEASE ; COMMON MUTATION ; BLOOD-PRESSURE ; FOLATE STATUS ; FOLIC-ACID
英文摘要

Objective: To evaluate the performance of methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism in predicting hyperhomocysteinemia (HHcy) in Chinese patients with hypertension.

Methods: We measured plasma total homocysteine tHcy level and C677T genotype in 1058 Chinese patients with hypertension from 4 previous studies. We used 10, 15, and 20 mol/L as cutoff values for the definition of mild, modest, and severe HHcy, respectively. Logistic models for HHcy were built from the study sample using the C677T genotype as well as age and gender as predictors. The receiver-operating characteristics of the models were evaluated.

Results: Our major findings are that (1) C677T TT genotype is consistently associated with a higher tHcy across the 4 studies, with an increase in size ranging from 38% to 68% in the 4 studies and 51% overall. The C677T polymorphism independently explained about 14% of the total variance of the normalized tHcy. (2) The TT genotype is associated with a large increase in odds ratio (OR) for HHcy. Overall, the multivariate-adjusted ORs for the TT genotype are 3.9 (95% confidence interval [CI]: 2.4-6.4), 6.5 (95% CI: 4.0-10.6), and 17.9 (95% CI: 8.4-38.1) for mild, modest, and severe HHcy, respectively. (3) Overall, the predicting performance increased with HHcy severity, with sensitivity improving from 31.0% for mild HHcy to 70.3% for severe HHcy, and with specificity slightly decreasing from 85.4% to 80.3%. Inclusion of gender and age as predictors significantly improves the sensitivity, especially for predicting mild HHcy.

Conclusion: With an excellent sensitivity and a modest specificity, C677T could be a useful screening marker for severe HHcy.

语种英语
所属项目编号2012CB517703 ; 81373484 ; 81141116 ; 30700454
资助者Major State Basic Research Development Program ; National Natural Science Foundation of China ; Major State Basic Research Development Program ; National Natural Science Foundation of China
WOS记录号WOS:000360827200010
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53694
Collection北京大学第一临床医学院_心血管内科
作者单位1.Dept Med, Beijing, Peoples R China
2.Anhui Univ, Sch Life Sci, Hefei 230061, Peoples R China
3.Peking Univ, Hosp 1, Dept Pharm, Beijing 100871, Peoples R China
4.Anhui Med Univ, Inst Biomed, Hefei, Peoples R China
5.Southern Med Univ, Nanfang Hosp, Div Nephrol, Guangzhou, Guangdong, Peoples R China
6.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China
7.Anhui Univ, Sch Life Sci, Ctr Stem Cell & Translat Med, Hefei 230061, Peoples R China
8.Acad Mil Med Sci, Affiliated Hosp, Dept Clin Pharmacol, Beijing, Peoples R China
9.Capital Med Univ, Beijing Tiantan Hosp, Dept Pharm, Beijing, Peoples R China
10.China Med Acad, Beijing Fuwai Hosp, Beijing, Peoples R China
11.Peoples Liberat Army Gen Hosp, Dept Geriatr Cardiol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wang, Yu,Xu, Xin,Huo, Yong,et al. Predicting Hyperhomocysteinemia by Methylenetetrahydrofolate Reductase C677T Polymorphism in Chinese Patients With Hypertension[J]. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS,2015,21(7):661-666.
APA Wang, Yu.,Xu, Xin.,Huo, Yong.,Liu, Dahai.,Cui, Yimin.,...&Jiang, Shanqun.(2015).Predicting Hyperhomocysteinemia by Methylenetetrahydrofolate Reductase C677T Polymorphism in Chinese Patients With Hypertension.CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS,21(7),661-666.
MLA Wang, Yu,et al."Predicting Hyperhomocysteinemia by Methylenetetrahydrofolate Reductase C677T Polymorphism in Chinese Patients With Hypertension".CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS 21.7(2015):661-666.
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