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Reevaluation of predictive value of ACL and anti-beta 2GP1 antibody for thrombosis in patients with systemic lupus erythematosus: from a perspective of a practical world
Deng, Xiaoli; Liu, Xiangyuan
关键词Thrombosis Lupus Acl Anti-beta 2gp1 Antibody
刊名RHEUMATOLOGY INTERNATIONAL
2012-12-01
DOI10.1007/s00296-011-2267-2
32期:12页:3881-3886
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]ANTICARDIOLIPIN ANTIBODIES ; ANTIPHOSPHOLIPID SYNDROME ; CLASSIFICATION ; CRITERIA ; DISEASE ; WOMEN ; RISK
英文摘要

Detection of ACL (anticardiolipin, ACL) and anti-beta 2GP1 (beta2 glycoprotein1, beta 2GP1) antibody has been widely used, and the criteria of APS (Antiphospholipid syndrome, APS) have been used for the prediction of thrombosis in patients with SLE. What is the exact predictive value of these two antibodies? Is it really necessary to apply the criteria of APS to each patient just for the purpose of prediction of thrombosis? The aim of this retrospective study is to reevaluate the predictive value of different combination of ACL and anti-beta 2GP1 antibody for thrombosis formation in Chinese patients with SLE. Patients fulfilling the 1997 ACR classification criteria for SLE were enrolled and retrospectively analyzed. Thrombosis was confirmed by ultrasound, cerebral MRI, computed tomography pulmonary angiogram and angiography. Both IgG and IgM isotype of ACL and anti-beta 2GP1 antibody were detected with ELISA kit. ROC curves and other parameters of diagnostic test for different combination of ACL and anti-beta 2GP1 were analyzed and compared. 175 patients were recruited and thrombosis was diagnosed in 49 patients. In patients with thrombosis, 95.9% had been treated with glucocorticoids before detection of the two antibodies, 44.9% had hypertension and 53.1% had hyperlipidemia. ACL was positive in 28 patients (16%), and anti-beta 2GP1 antibody was positive in 21 patients (12%). The presence of a low or higher titer of either ACL (> 12 RU/ml) or anti-beta 2GP1 antibody (> 20 RU/ml) once has the highest predictive accuracy. The sensitivity, the specificity, the Youden′s index and the area under ROC curve are 61.11%, 81.11%, 0.4222 and 0.711 respectively. A transient low or higher titer of ACL or anti-beta 2GP1 antibody had a good predictive value for thrombosis in patients with SLE, especially in those with other traditional risk factors for thrombosis and those treated with glucocorticoids.

语种英语
WOS记录号WOS:000311515600026
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53695
专题北京大学第三临床医学院
作者单位Peking Univ, Hosp 3, Dept Rheumatol & Immunol, Beijing 100871, Peoples R China
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GB/T 7714
Deng, Xiaoli,Liu, Xiangyuan. Reevaluation of predictive value of ACL and anti-beta 2GP1 antibody for thrombosis in patients with systemic lupus erythematosus: from a perspective of a practical world[J]. RHEUMATOLOGY INTERNATIONAL,2012,32(12):3881-3886.
APA Deng, Xiaoli,&Liu, Xiangyuan.(2012).Reevaluation of predictive value of ACL and anti-beta 2GP1 antibody for thrombosis in patients with systemic lupus erythematosus: from a perspective of a practical world.RHEUMATOLOGY INTERNATIONAL,32(12),3881-3886.
MLA Deng, Xiaoli,et al."Reevaluation of predictive value of ACL and anti-beta 2GP1 antibody for thrombosis in patients with systemic lupus erythematosus: from a perspective of a practical world".RHEUMATOLOGY INTERNATIONAL 32.12(2012):3881-3886.
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