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Progress in the study on the composition and formation: mechanism of gallstone
Sun, Y; Yang, ZL; Shen, GR; Zhou, Y; Zhou, XS; Wu, JG; Xu, GX
关键词Gallstone Mechanism Of Formation Periodic Precipitation Fractal Pattern Bile Salts
刊名SCIENCE IN CHINA SERIES B-CHEMISTRY
2001-10-01
44期:5页:449-456
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]BILE-SALT SYSTEM ; PIGMENT GALLSTONES ; CHAOTIC PRECIPITATION ; EPR SPECTROSCOPY ; BILIRUBIN ; MODEL ; GEL
英文摘要

Our serial studies from 1970s on chemical composition, structure determination and formation mechanism of gallstones were reviewed. The chemical component investigation of brown-pigment gallstone demonstrated that it consists of macromolecules such as proteins, glycoproteins, polysaccharides, bilirubin polymers and pigment polymers, and biomolecules such as cholesterol, bile salts, calcium salts of carbonate, phosphate, fatty acids and bilirubinate as well as various metal ions. The binding of metal ions with bile salts and bilirubin plays important roles in gallstone formation, i.e., calcium bilirubinate complex is:the major constitute of brown-pigment gallstones, and copper bilirubinate complex is critical in the black color appearance of black-pigment gallstone. The cross section of many gallstones exhibits a concentric ring structure composed of various small particles with a fractal character. This is nonlinear phenomenon in gallstone formation. A typical model system of metal ions-deoxycholate (or cholate)-gel was chosen to mimic an in vitro pattern formation system. The experimental results suggested that a nonlinear scientific concept should be considered in understanding gallstone formation. Minor changes in the chemical composition and/or the microenvironment may lead to very different precipitate patterns: with a variety of shapes, colors, appearances, and structures. A new model was suggested that periodical templets of periodical and fractal patterns were formed in the initial stage, then the spatio-temporal patterns grew gradually on it. Furthermore, the interaction between divalent metal ions and bile salts in vitro was investigated, and the results indicated that non-stoichiometric M(DC)(2)-NaDC mixed complexes with mixed micelles structure can be formed in physiological condition.

语种英语
WOS记录号WOS:000171967200001
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被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53705
专题北京大学药学院_化学生物学系
作者单位1.Peking Univ, Coll Med, Beijing 100871, Peoples R China
2.Peking Univ, Coll Chem & Mol Engn, Dept Chem Biol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Sun, Y,Yang, ZL,Shen, GR,et al. Progress in the study on the composition and formation: mechanism of gallstone[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,2001,44(5):449-456.
APA Sun, Y.,Yang, ZL.,Shen, GR.,Zhou, Y.,Zhou, XS.,...&Xu, GX.(2001).Progress in the study on the composition and formation: mechanism of gallstone.SCIENCE IN CHINA SERIES B-CHEMISTRY,44(5),449-456.
MLA Sun, Y,et al."Progress in the study on the composition and formation: mechanism of gallstone".SCIENCE IN CHINA SERIES B-CHEMISTRY 44.5(2001):449-456.
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