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学科主题: 临床医学
题名:
Combined Phenotype of 4 Markers Improves Prognostic Value of Patients With Colon Cancer
作者: Liu, Caiyun1,2; Qu, Like1,2; Dong, Bin3; Xing, Xiaofang1,2; Ren, Tingting1,2; Zeng, Yan1,2; Jiang, Beihai1,2; Meng, Lin1,2; Wu, Jian1,2; Shou, Chengchao1,2
关键词: Colon cancer ; Lymph node metastasis ; Immunochemistry ; Combined analysis
刊名: AMERICAN JOURNAL OF THE MEDICAL SCIENCES
发表日期: 2012-04-01
DOI: 10.1097/MAJ.0b013e31822cb4cd
卷: 343, 期:4, 页:295-302
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: SYNUCLEIN-GAMMA-GENE ; HUMAN GASTRIC-CANCER ; SOFT-TISSUE SARCOMA ; COLORECTAL-CANCER ; BREAST-CANCER ; MONOCLONAL-ANTIBODIES ; PRL-3 PHOSPHATASE ; LIVER METASTASIS ; STEM-CELLS ; HIWI GENE
英文摘要:

Introduction: Combination of multiple biomarkers representing distinct aspects of tumor biology will have a better prognostic value. This study was to identify prognostic subgroups of colon adenocarcinoma by combined analysis of synuclein-gamma (SNCG), a human homologue of piwi (Hiwi), phosphatase of regenerating liver-3 (PRL-3), arrest-defective protein 1, homolog A (ARD1) and clinicopathologic features in 225 colon adenocarcinoma specimens. Methods: Immunohistochemistry for 4 tumor markers was performed in whole tissue sections from 225 colon adenocarcinoma patients with complete clinicopathologic data and up to 10-year follow-up. The immunohistochemical expression patterns were examined individually and in multimarker combinations. Univariate and multivariate analyses were performed to identify independent predictive markers of poor outcome. Results: With the tumor marker positive rate [32.0% (62/225) for SNCG; 76.9% (173/225) for combined SNCG/Hiwi/PRL-3/ARD1] and the detecting accuracy [61.9% (252/407) for SNCG; 82.6% (336/407) for combined SNCG/Hiwi/PRL-3/ARD1] increasing, incremental value of combined SNCG/Hiwi/PRL-3/ARD1 (P < 0.001; hazard ratios (HR), 3.2) to poor outcome was found. Stratified by lymph node, Hiwi alone (P = 0.004; HR, 3.2) led to poor outcome in patients without lymph node metastasis (LN-), and SNCG (P < 0.001; HR, 2.5) had independently poor prognostic value for patients with lymph node metastasis (LN+). Conclusions: Multimarker phenotypes improved tumor positive rate, detecting accuracy and prognostic value. In addition, a subgroup of more aggressive tumors can be identified by evaluating Hiwi level in LN- cancer, and SNCG level in LN+ cancer.

语种: 英语
所属项目编号: 2009CB521805 ; 2006AA02A249 ; 30671024 ; 30600287 ; 30772489 ; 30973407 ; 2009-3162
项目资助者: National 973 Program ; National 863 Program ; National Natural Science Foundation of China ; Capital Medical Development Foundation of Beijing
WOS记录号: WOS:000302158400007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53706
Appears in Collections:北京大学临床肿瘤学院_病理科_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ, Beijing 100871, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Dept Biochem & Mol Biol, Beijing 100871, Peoples R China
3.Peking Univ, Canc Hosp & Inst, Dept Pathol, Beijing 100871, Peoples R China

Recommended Citation:
Liu, Caiyun,Qu, Like,Dong, Bin,et al. Combined Phenotype of 4 Markers Improves Prognostic Value of Patients With Colon Cancer[J]. AMERICAN JOURNAL OF THE MEDICAL SCIENCES,2012,343(4):295-302.
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