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学科主题: 药物依赖
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Stress impairs reconsolidation of drug memory via glucocorticoid receptors in the basolateral amygdala
作者: Wang, Xiao-Yi1; Zhao, Mei1; Ghitza, Udi E.2; Li, Yan-Qin1; Lu, Lin1
关键词: memory ; stress ; morphine ; corticosterone ; reconsolidation ; amygdala
刊名: JOURNAL OF NEUROSCIENCE
发表日期: 2008-05-21
DOI: 10.1523/JNEUROSCI.0750-08.2008
卷: 28, 期:21, 页:5602-5610
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CORTICOTROPIN-RELEASING-FACTOR ; CONDITIONED PLACE PREFERENCE ; COCAINE-SEEKING ; INDUCED RELAPSE ; PROTEIN-SYNTHESIS ; HEROIN-SEEKING ; DISRUPTING RECONSOLIDATION ; MOLECULAR-MECHANISMS ; DECLARATIVE MEMORY ; NEURAL MECHANISMS
英文摘要:

Relapse to drug taking induced by exposure to cues associated with drugs of abuse is a major challenge to the treatment of drug addiction. Previous studies indicate that drug seeking can be inhibited by disrupting the reconsolidation of a drug-related memory. Stress plays an important role in modulating different stages of memory including reconsolidation, but its role in the reconsolidation of a drug-related memory has not been investigated. Here, we examined the effects of stress and corticosterone on reconsolidation of a drug-related memory using a conditioned place preference (CPP) procedure. We also determined the role of glucocorticoid receptors (GRs) in the basolateral amygdala (BLA) in modulating the effects of stress on reconsolidation of this memory. We found that rats acquired morphine CPP after conditioning, and that this CPP was inhibited by stress given immediately after re-exposure to a previously morphine-paired chamber ( a reconsolidation procedure). The disruptive effect of stress on reconsolidation of morphine related memory was prevented by inhibition of corticosterone synthesis with metyrapone or BLA, but not central amygdala (CeA), injections of the glucocorticoid (GR) antagonist RU38486 [( 11,17)-11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one]. Finally, the effect of stress on drug related memory reconsolidation was mimicked by systemic injections of corticosterone or injections of RU28362 [11,17-dihydroxy- 6-methyl-17-(1-propynyl) androsta-1,4,6-triene-3-one] ( a GR agonist) into BLA, but not the CeA. These results show that stress blocks reconsolidation of a drug-related memory, and this effect is mediated by activation of GRs in the BLA.

语种: 英语
WOS记录号: WOS:000256066200022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53708
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100083, Peoples R China
2.NIDA, NIH, Behav Neurosci Branch, Baltimore, MD 21224 USA

Recommended Citation:
Wang, Xiao-Yi,Zhao, Mei,Ghitza, Udi E.,et al. Stress impairs reconsolidation of drug memory via glucocorticoid receptors in the basolateral amygdala[J]. JOURNAL OF NEUROSCIENCE,2008,28(21):5602-5610.
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