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Stress impairs reconsolidation of drug memory via glucocorticoid receptors in the basolateral amygdala
Wang, Xiao-Yi1; Zhao, Mei1; Ghitza, Udi E.2; Li, Yan-Qin1; Lu, Lin1
关键词Memory Stress Morphine Corticosterone Reconsolidation Amygdala
刊名JOURNAL OF NEUROSCIENCE
2008-05-21
DOI10.1523/JNEUROSCI.0750-08.2008
28期:21页:5602-5610
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]CORTICOTROPIN-RELEASING-FACTOR ; CONDITIONED PLACE PREFERENCE ; COCAINE-SEEKING ; INDUCED RELAPSE ; PROTEIN-SYNTHESIS ; HEROIN-SEEKING ; DISRUPTING RECONSOLIDATION ; MOLECULAR-MECHANISMS ; DECLARATIVE MEMORY ; NEURAL MECHANISMS
英文摘要

Relapse to drug taking induced by exposure to cues associated with drugs of abuse is a major challenge to the treatment of drug addiction. Previous studies indicate that drug seeking can be inhibited by disrupting the reconsolidation of a drug-related memory. Stress plays an important role in modulating different stages of memory including reconsolidation, but its role in the reconsolidation of a drug-related memory has not been investigated. Here, we examined the effects of stress and corticosterone on reconsolidation of a drug-related memory using a conditioned place preference (CPP) procedure. We also determined the role of glucocorticoid receptors (GRs) in the basolateral amygdala (BLA) in modulating the effects of stress on reconsolidation of this memory. We found that rats acquired morphine CPP after conditioning, and that this CPP was inhibited by stress given immediately after re-exposure to a previously morphine-paired chamber ( a reconsolidation procedure). The disruptive effect of stress on reconsolidation of morphine related memory was prevented by inhibition of corticosterone synthesis with metyrapone or BLA, but not central amygdala (CeA), injections of the glucocorticoid (GR) antagonist RU38486 [( 11,17)-11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one]. Finally, the effect of stress on drug related memory reconsolidation was mimicked by systemic injections of corticosterone or injections of RU28362 [11,17-dihydroxy- 6-methyl-17-(1-propynyl) androsta-1,4,6-triene-3-one] ( a GR agonist) into BLA, but not the CeA. These results show that stress blocks reconsolidation of a drug-related memory, and this effect is mediated by activation of GRs in the BLA.

语种英语
WOS记录号WOS:000256066200022
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被引频次:82[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53708
专题中国药物依赖性研究所
作者单位1.Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100083, Peoples R China
2.NIDA, NIH, Behav Neurosci Branch, Baltimore, MD 21224 USA
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Wang, Xiao-Yi,Zhao, Mei,Ghitza, Udi E.,et al. Stress impairs reconsolidation of drug memory via glucocorticoid receptors in the basolateral amygdala[J]. JOURNAL OF NEUROSCIENCE,2008,28(21):5602-5610.
APA Wang, Xiao-Yi,Zhao, Mei,Ghitza, Udi E.,Li, Yan-Qin,&Lu, Lin.(2008).Stress impairs reconsolidation of drug memory via glucocorticoid receptors in the basolateral amygdala.JOURNAL OF NEUROSCIENCE,28(21),5602-5610.
MLA Wang, Xiao-Yi,et al."Stress impairs reconsolidation of drug memory via glucocorticoid receptors in the basolateral amygdala".JOURNAL OF NEUROSCIENCE 28.21(2008):5602-5610.
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